UVA-induced carbon-centred radicals in lightly pigmented cells detected using ESR spectroscopy

Kassouf, Nick; Kay, Christopher W. M.; Volkov, A.; Chiang, Shih‐Chieh; Birch‐Machin, Mark A.; El‐Khamisy, Sherif F.; Haywood, Rachel

doi:10.1016/j.freeradbiomed.2018.07.019

Cited by 5 publications

(3 citation statements)

References 51 publications

(63 reference statements)

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Section: Melanins and Covid-19mentioning

confidence: 99%

“…Recent EPR studies have also shown the photo-production of ROS from melanins in melanocytes and skin itself [51,52]. In Kassouf et al [51], the spin trapping of radicals produced via UVA irradiation of melanocytes and melanoma cells showed higher levels of spin trapped carbon-centred radicals in lightly pigmented cells than in darkly pigmented or even non-pigmented cells. Albrecht et al [52] used EPR spin trapping to detect radicals directly in irradiated skin and found radical production when the skin was irradiated with either UV, visible, or even infra-red light.…”

Section: Melanins and Covid-19mentioning

confidence: 99%

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The Reactive Oxygen Species Singlet Oxygen, Hydroxy Radicals, and the Superoxide Radical Anion—Examples of Their Roles in Biology and Medicine

Edge

Truscott

2021

Oxygen

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Reactive oxygen species comprise oxygen-based free radicals and non-radical species such as peroxynitrite and electronically excited (singlet) oxygen. These reactive species often have short lifetimes, and much of our understanding of their formation and reactivity in biological and especially medical environments has come from complimentary fast reaction methods involving pulsed lasers and high-energy radiation techniques. These and related methods, such as EPR, are discussed with particular reference to singlet oxygen, hydroxy radicals, the superoxide radical anion, and their roles in medical aspects, such as cancer, vision and skin disorders, and especially pro- and anti-oxidative processes.

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Section: Melanins and Covid-19mentioning

confidence: 99%

Section: Melanins and Covid-19mentioning

confidence: 99%

The Reactive Oxygen Species Singlet Oxygen, Hydroxy Radicals, and the Superoxide Radical Anion—Examples of Their Roles in Biology and Medicine

Edge

Truscott

2021

Oxygen

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“…generated in the process of nitric oxide synthesis, and these oxygen-centered radicals are grouped into reactive oxygen species (ROS) [ 39 , 45 ]. Ultraviolet-A (UV-A) irradiation can potentially generate carbon radicals (carbon-centered radicals, reactive carbon species (RCS)) and hydroxyl radicals and damage nucleic acids in the skin cells/low pigmented (low melanin) skin cells [ 53 ].…”

Section: Oxidants and Antioxidantsmentioning

confidence: 99%

Myricetin: a Multifunctional Flavonol in Biomedicine

Agraharam

Girigoswami

2022

Curr Pharmacol Rep

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Purpose of Reveiw The root cause of many diseases like CVD, cancer, and aging is free radicals which exert their effect by interfering with different metabolic pathways. The sources of free radicals can be exogenous, like UV rays from sunlight, and endogenous due to different metabolic by-products. In our body, there are defense mechanisms present, such as antioxidant enzymes and antioxidant molecules to combat these free radicals, but if there is an overload of these free radicals in our body, the defense system may not be sufficient to neutralize these free radicals. In such situations, we are exposed to a chronic low dose of oxidants creating oxidative stress, which is responsible for eliciting different diseases. Recent Findings Pubmed and Google Scholar are the search engines used to sort out relevant papers on myricetin and its role in combating many diseases. Myricetin is present in many fruits and vegetables and is a known antioxidant. It can elevate the antioxidant enzyme levels; reduces the lipid peroxidation; and is known to protect against cancer. In the case of myocardial dysfunction, myricetin has been shown to suppress the inflammatory cytokines and reduced the mortality rate. Myricetin has also been found to reduce platelet aggregation and control the viral infections by interfering in the DNA replication pathways. Summary In this paper, we have briefly reviewed about the different type and site of free radicals and the role of myricetin in addressing the ROS and different diseases.

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Spin-Trapping Theory and Applications

Haywood¹

2021

Encyclopedia of Biophysics

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UVA-induced carbon-centred radicals in lightly pigmented cells detected using ESR spectroscopy

Abstract: Rachel (2018) UVA-induced carbon-centered radicals in lightly pigmented cells detected using ESR spectroscopy. Free Radical Biology and Medicine .

Cited by 5 publications

References 51 publications

The Reactive Oxygen Species Singlet Oxygen, Hydroxy Radicals, and the Superoxide Radical Anion—Examples of Their Roles in Biology and Medicine

The Reactive Oxygen Species Singlet Oxygen, Hydroxy Radicals, and the Superoxide Radical Anion—Examples of Their Roles in Biology and Medicine

Myricetin: a Multifunctional Flavonol in Biomedicine

Spin-Trapping Theory and Applications

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