UVA1 phototherapy for disseminated granuloma annulare

Schnopp, Christina; Tzaneva, Stanislava; Mempel, Martin; Schulmeister, Karl; Abeck, Dietrich; Tanew, Adrian

doi:10.1111/j.1600-0781.2005.00145.x

Cited by 41 publications

(21 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Small studies using UV-A1 have shown improvement in lesions; however, relapses were common after discontinuation of therapy. [103][104][105] Psoralen-UV-A (PUVA) has been effective in clearing the lesions of GA in case reports and small case series. [106][107][108][109] As in the case of UV-A1 therapy, although many patients showed improvement, [106][107][108][109] recurrence was common and maintenance therapy was required.…”

Section: Evaluation and Managementmentioning

confidence: 99%

“…Immunosuppression with methotrexate, cyclosporine, and TNF-a inhibitors can be considered in patients with severe disease that has been recalcitrant to other therapies. 28,[87][88][89][90][91][93][94][95][96][97][98][99][100][101][102][103][104][105][106][107][108][109][114][115][116][117][118][119][120][121][122][123][124]126,127,129,130,[132][133][134][140][141][142][144][145][146][147][148]150,…”

Section: Evaluation and Managementmentioning

confidence: 99%

“…Reported skin-directed and systemic treatments of granuloma annulare BB-UVB102 3 Â Per wk Â 16 wk Good or excellent response C UV-A1[103][104][105] High dose and medium dose Improvement but with relapse…”

mentioning

confidence: 98%

See 2 more Smart Citations

Granuloma Annulare

Keimig

2015

Dermatologic Clinics

View full text Add to dashboard Cite

Granuloma annulare (GA) is a noninfectious granulomatous skin condition that can present with a variety of cutaneous morphologies. It is characterized by collagen degeneration, mucin deposition, and palisaded or interstitial histiocytes. Although the mechanism underlying development of GA is unknown, studies point to a cell-mediated hypersensitivity reaction to an as-yet undetermined antigen. Systemic associations with diabetes, thyroid disorders, lipid abnormalities, malignancy, and infection are described in atypical GA. Treatment is divided into localized skin-directed therapies and systemic immunomodulatory or immunosuppressive therapies. The selected treatment modality should be based on disease severity, comorbid conditions, consideration of potential side effects, and patient preference.

show abstract

Section: Evaluation and Managementmentioning

confidence: 99%

Section: Evaluation and Managementmentioning

confidence: 99%

See 1 more Smart Citation

Granuloma Annulare

Keimig

2015

Dermatologic Clinics

View full text Add to dashboard Cite

show abstract

“…Hence, as oral PUVA and bath-PUVA only partially suppress disease activity, chemophototherapy should be reserved for severe and recalcitrant cases, especially as the cumulative dosage has to be limited due to its carcinogenic potential. Comparable results were achieved in a study including 20 patients treated with UVA1: in 50% of the patients lesions cleared or at least markedly improved, but in the follow-up 7 of the 9 responders relapsed within an average time span of 3 months [36]. …”

Section: Discussionmentioning

confidence: 68%

Treatment of Disseminated Granuloma Annulare with Oral Vitamin E: ‘Primum Nil Nocere'

et al. 2013

View full text Add to dashboard Cite

Background: Disseminated granuloma annulare (DGA) is a benign and usually asymptomatic skin disease. However, many patients feel aesthetically disfigured and ask for treatment. Until today, no standard therapy is recommended. Objective: To evaluate the safety and efficacy of oral vitamin E treatment compared to the natural course of DGA. Methods: This single-centre observational cohort study included 38 consecutive patients with histologically confirmed DGA. 21 patients underwent treatment with oral vitamin E, whereas 17 patients preferred a wait-and-see approach. Results: Complete healing (40%) and improvement (30%) were frequently seen under oral vitamin E therapy. However, DGA also spontaneously disappeared in 31% and improved in 25% of untreated control patients. Vitamin E therapy was very well tolerated. Conclusions: Oral vitamin E treatment is a safe and probably effective therapy for DGA. As the natural course of DGA leads to complete healing or significant improvement in many cases, ‘primum nil nocere' should be the maxim.

show abstract

“…These cases clearly represent a major therapeutic challenge and many patients remain troubled by the appearance. The visible and unsightly nature of this skin condition has led to the proposal of a variety of topical and/or systemic treatment methods [5][6][7][8][9][10][11][12][13][14][15] (Table 1)-all with varying degrees of success and each with its own treatment-associated morbidity.…”

Section: Introductionmentioning

confidence: 99%