Uveal melanoma-associated survival in Scotland

Abstract

Background/Objectives The Scottish Ocular Oncology Service (SOOS) manages all patients with uveal melanoma (UM) in Scotland. Our aim was to determine the long-term all-cause and cause-specific survival of patients with UM, irrespective of treatment modality. Subjects/Methods A retrospective single-centre cohort study including all patients diagnosed with UM by the SOOS between 1/1/1998 and 31/12/2002. Data from the SOOS database were correlated with death records held by National Records of Scotland, which provided date, and all listed causes, of death for all deceased patients. Results Two hundred and eighteen patients were newly diagnosed with UM between 1/1/1998 and 31/12/2002. One hundred and fifteen (52.8%) were female. The mean (median) age at diagnosis was 63(65) years (range: 16-89). Of 179 choroidal melanomas, melanoma-specific survival was 92.3%, 87.4% and 83.8% at 5, 10 and 15 years, respectively. Cancerspecific survival was 85.8%, 71.8% and 62.3%. All-cause survival was 81.6% (146/179), 62.0% (111/179) and 46.7% (computed, fraction inexpressible). Of 26 ciliary body melanomas, melanoma-specific survival was 87.2%, 81.3% and 81.3% at 5, 10 and 15 years. Cancer-specific survival was 62.9%, 40.6% and 40.6%. All-cause survival was 61.5% (16/26), 38.5% (10/26) and 26.9% (7/26). Of 13 iris melanomas, at all three timepoints (5/10/15 years), melanoma-specific survival was 100%, cancer-specific survival was 92.3%, and all-cause survival was 76.9% (10/13). Conclusions Correlation of SOOS and national records survival data confirms 15-year melanoma-specific survival of 83.8%, 81.3% and 100% for choroidal, ciliary body and iris melanomas, respectively. We can now provide accurate survival data to our patients in Scotland.

Machine learning models for outcome prediction of Chinese uveal melanoma patients: A 15‐year follow‐up study

“…However, the metastasis rates in our study were higher at 18.9%, 27.2% and 31.4% (Figure 1B ). Similarly, our UM‐related survival rates were lower than those reported in Scotland (92.3%, 87.4% and 83.8%) [ 6 ]. A total of 183 patients in our study died of UM metastasis, and the median duration from metastasis to death was 7 months.…”

Clinical features and survival outcomes of ocular melanoma in a multi-ethnic Asian cohort

“…In Chinese (n = 171) and Korean (n = 33) patients, the 5-year metastasis-free survival rate approximates 80% 11 , 14 and are higher survival rates than European (n = 5,788) 21 and US cohorts (n = 1,003) 22 which reported 5-year survival rates bordering at or less than 70% 11 . However, these lower survival rates were based on older data and more recent studies in the US 23 and Scotland (n = 218) 24 report slightly higher 5-year cancer-specific survival ranging from 70 to 80%. On the contrary for CM, poorer survival outcomes have been reported in Asians compared to Caucasians, due in part to the advanced stages at presentation and poor melanoma awareness in Asia 15 , 17 .…”

“…In Chinese (n = 171) and Korean (n = 33) patients, the 5-year metastasis-free survival rate approximates 80% 11,14 and are higher survival rates than European (n = 5,788) 21 and US cohorts (n = 1,003) 22 which reported 5-year survival rates bordering at or less than 70% 11 . However, these lower survival rates were based on older data and more recent studies in the US 23 and Scotland (n = 218) 24 report…”

Genetics of Ocular Melanoma: Insights into Genetics, Inheritance and Testing

“…UM arises predominantly in the choroid followed by ciliary body and iris ( Figure 1 ) [ 7 , 8 ]. The prognosis of iris melanoma is favorable compared to melanoma of the choroid and ciliary body [ 9 , 10 ]. The 5-year overall survival of choroid and ciliary melanoma is 77–80% with a cancer specific 5-year survival rate of 76%.…”

“…One study even showed a 15-year melanoma specific survival up to 100%. [ 10 ] Although both groups have resemblances in their genetic makeup, the involvement of certain genes is different as well as their clinical behavior. Therefore, iris melanomas are considered a distinct subgroup within UM.…”