Uveal melanoma in African Americans: Diagnostic challenges

Yeşiltaş, Yağmur Seda; Oakey, Zackery; Wrenn, Jacquelyn; Yeaney, Gabrielle; Brainard, Jennifer; Lorek, Brandy; Singh, Arun D.

doi:10.1016/j.survophthal.2023.06.011

Cited by 2 publications

(1 citation statement)

References 33 publications

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“…An intriguing approach to comprehending ITH and its role in therapeutic resistance and cancer recurrence involves analyzing CTCs and cfDNA. Genomewide single-cell RNA sequencing and DNA sequencing techniques conducted on CTCs have provided valuable insights into tumor heterogeneity [195,249,250].…”

Section: Advancing the Detection And Analysis Of Ctcs In Um Through S...mentioning

confidence: 99%

Heterogeneity and molecular landscape of melanoma: implications for targeted therapy

Beigi,

Lanjanian,

Fayazi

et al. 2024

Mol Biomed

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Uveal cancer (UM) offers a complex molecular landscape characterized by substantial heterogeneity, both on the genetic and epigenetic levels. This heterogeneity plays a critical position in shaping the behavior and response to therapy for this uncommon ocular malignancy. Targeted treatments with gene-specific therapeutic molecules may prove useful in overcoming radiation resistance, however, the diverse molecular makeups of UM call for a patient-specific approach in therapy procedures. We need to understand the intricate molecular landscape of UM to develop targeted treatments customized to each patient's specific genetic mutations. One of the promising approaches is using liquid biopsies, such as circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA), for detecting and monitoring the disease at the early stages. These non-invasive methods can help us identify the most effective treatment strategies for each patient. Single-cellular is a brand-new analysis platform that gives treasured insights into diagnosis, prognosis, and remedy. The incorporation of this data with known clinical and genomics information will give a better understanding of the complicated molecular mechanisms that UM diseases exploit. In this review, we focused on the heterogeneity and molecular panorama of UM, and to achieve this goal, the authors conducted an exhaustive literature evaluation spanning 1998 to 2023, using keywords like "uveal melanoma, “heterogeneity”. “Targeted therapies”," "CTCs," and "single-cellular analysis".

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Section: Advancing the Detection And Analysis Of Ctcs In Um Through S...mentioning

confidence: 99%

Heterogeneity and molecular landscape of melanoma: implications for targeted therapy

Beigi,

Lanjanian,

Fayazi

et al. 2024

Mol Biomed

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STAT6/LINC01637 axis regulates tumor growth via autophagy and pharmacological targeting STAT6 as a novel strategy for uveal melanoma

Liu,

Yao,

Huang

et al. 2024

Cell Death Dis

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Compelling evidence has revealed a novel function of the STAT pathway in the pathophysiology of uveal melanoma (UM); however, its regulatory mechanisms remain unclear. Here, we analyzed the clinical prognostic value of STAT family genes in UM patients using bioinformatics approaches and found that high STAT6 expression is associated with poor prognosis. Furthermore, cellular experiments and a nude mouse model demonstrated that STAT6 promotes UM progression through the autophagy pathway both in vivo and in vitro. Next, RIP-PCR revealed that STAT6 protein binds to LINC01637 mRNA, which in turn regulates STAT6 expression to promote UM growth. Finally, molecular docking indicated that STAT6 is a target of Zoledronic Acid, which can delay UM tumorigenicity by inhibiting STAT6 expression. Taken together, our results indicate that the STAT6/LINC01637 axis promotes UM progression via autophagy and may serve as a potential therapeutic target for UM.

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Uveal melanoma in African Americans: Diagnostic challenges

Cited by 2 publications

References 33 publications

Heterogeneity and molecular landscape of melanoma: implications for targeted therapy

Heterogeneity and molecular landscape of melanoma: implications for targeted therapy

STAT6/LINC01637 axis regulates tumor growth via autophagy and pharmacological targeting STAT6 as a novel strategy for uveal melanoma

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