Uveitis masquerade syndromes

Rothová, Aniki; Ooijman, Francien; Kerkhoff, F T; Lelij, Allegonda Van der; Lokhorst, Henk M.

doi:10.1016/s0161-6420(00)00499-1

Cited by 183 publications

(151 citation statements)

References 39 publications

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“…26 Lymphoma may masquerade as iritis, anterior uveitis or panuveitis. 2,3,7,12,[25][26][27] Incorrect diagnosis of the uveitic syndrome may have severe consequences. Uveal involvement may be the initial manifestation of extranodal lymphoma.…”

Section: Anterior Segmentmentioning

confidence: 99%

Ophthalmic manifestations of lymphoma

Omoti

2007

Ann Afr Med

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Background: Ophthalmic involvement in lymphoma is a relatively rare condition that can result from a primary intraocular lymphoma or an intraocular manifestation of systemic lymphoma. This report reviews the ophthalmic manifestations of lymphoma. Methods: Review of relevant information from journal articles and Internet search. Results: Almost all the structures in the orbit, adnexiae and eye can be involved in lymphoma. Lymphoma of the eye and adnexiae are most frequently of B lineage. Most of the ocular manifestations frequently masquerade as other more benign intraocular conditions including allergic or infectious conjunctivitis, uveitis, multiple evanescent white dot syndrome, acute retinal necrosis or herpetic retinitis. Correct diagnosis thus depends on a high index of suspicion and frequently requires radiologic imaging, histologic analysis, particularly vitreous biopsy or flow cytometry, subretinal aspiration and retinal biopsy. Diagnosis is often delayed and may lead to a fatal outcome. Recognition of its modes of presentation facilitates early diagnosis and treatment that may improve prognosis. Conclusions: It is important to review the ocular manifestations of lymphoma to assist the ophthalmologist to play a pivotal role in the prompt diagnosis and treatment of ocular lymphoma, and the haematologist/oncologist to recognize the need for a complete ophthalmic evaluation in the diagnosis, follow-up and management of lymphoma patients.Key words: lymphoma, ophthalmic manifestations, masquerade, vitreous biopsy Résumé Introduction: La participation ophtalmique dans lymphome est une condition rélativement rare qui peut être provoqué par lymphome intraoculaire primaire ou une manifestation intraoculaire du lymphome systématique. Ce rapport fait une rétrospective des manifestation ophtalmique du lymphome. Méthodes: Une rétrospective des informations pertinentes des articles dans les journaux et des recherches dans l'internet. Résultats: Prèsque toutes les structures dans l'orbite, adnexiae et l'oeil peuvent participer dans lymphome. Lymphome de l'oeil et d'adnexiae sont le plus souvent du lignage B. La plupart des manifestations oculaires les plus souvent mascarade comme d'autre conditions intraoculaire plus bénigne y compris des infections conjunctivite ou allergique, uveite, syndrome tacheté du blanc évanescent multiple, nécrose aigue rétine ou rétinite herpetique. Donc diagnostique correcte dépend d'index plus élevé du soupçon et l'imaging radiologique est très fréquemment éxigé, analyse histologique, la biopsie vitreouse en particulier ou bien écoulement cytométrie, aspiration sousrétine et la biopsie rétine. Le diagnostique est souvent rétardé et pourrait aboutir à un résultat sérieux. Réconnaissance de son mode de présentation facilitera un diagnostique précoce et un traitement qui pourrait améliorer la prognose. Conclusion: C'est très important de faire une rétrospective des manifestations oculaires du lymphome afin d'aider l'ophtamologiste de jouer un rôle clef dans un diagnostique précoce et t...

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Section: Anterior Segmentmentioning

confidence: 99%

Ophthalmic manifestations of lymphoma

Omoti

2007

Ann Afr Med

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“…11,12 We observed a median delay of 4 months after onset of symptoms in our patients, and the mean delay (10.2 months) was similar to or shorter than that reported by other groups. 10,11,13,39 Large-cell lymphoma, which is usually of the B-cell phenotype, may be recognised on either air-dried or fixed cytospin preparations of CSF or vitreous, which have been handled correctly ( Figure 4A). However, difficulties in cytological diagnosis are well recognised because the large lymphoma cells may be fragile and susceptible to damage during collection; there may be a large mixed inflammatory and necrotic infiltrate, and viable malignant cells may be scarce.…”

Section: Survival After Rt (Months)mentioning

confidence: 99%

Intraocular lymphoma: a series of 14 patients with clinicopathological features and treatment outcomes

Hoffman

McKelvie

Hall

et al. 2003

Eye

138

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Aims To assess the clinical features, pathology, mortality (systemic outcome) and ocular complications (visual outcome) of a cohort of patients treated for intraocular lymphoma. Methods Retrospective case analysis of medical records and review of pathology of a consecutive series of patients presenting with intraocular lymphoma in Melbourne over 11 years between 1990 and 2000. Categorical factors influencing survival were examined by the Kaplan-Meier estimator and groups compared with the log rank test.

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“…35,52,68 Due to the link to CNS disease, patients with suspected PIOL should receive a thorough medical and neurological examination, neuroimaging of the brain and orbits, and a lumbar puncture. Cerebrospinal fluid should be sent for routine cytological, chemistry, and cytokine analysis.…”

Section: Discussionmentioning

confidence: 99%

Primary Testicular and Intraocular Lymphomas: Two Case Reports and a Review of the Literature

Wallace

Altemare

Shen

et al. 2006

Survey of Ophthalmology

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Testicular lymphoma is a rare neoplasm of the testis that is most commonly seen in older patients. It metastasizes preferentially to extranodal sites, including the skin, central nervous system, Waldeyer ring, contralateral testis, and lung. Two case reports of patients with a history of testicular lymphoma who developed involvement of the vitreous and retina are presented. These are interesting cases as the testis, central nervous system, and eye are all immune privileged organs, which may account for occurrence of disease in these sites. Histopathologic examination of diagnostic vitrectomy specimens from both cases showed atypical lymphoid cells with immunoglobulin heavy chain (IgH) gene rearrangements, consistent with the diagnosis of intraocular B-cell lymphoma. The results of a literature review of all reports of ocular involvement with testicular lymphoma are discussed. Patients with testicular lymphoma are at risk for relapse, particularly in the central nervous system. Clinicians should be suspicious for intraocular lymphoma in patients with a history of testicular lymphoma who present with vitritis or retinal lesions.

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Uveitis masquerade syndromes

Cited by 183 publications

References 39 publications

Ophthalmic manifestations of lymphoma

Ophthalmic manifestations of lymphoma

Intraocular lymphoma: a series of 14 patients with clinicopathological features and treatment outcomes

Primary Testicular and Intraocular Lymphomas: Two Case Reports and a Review of the Literature

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