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D’Mello, J. P. F.; Macdonald, A. M. C.; Postel, D.; Dijksma, W. T. P.; Dujardin, A.; Placinta, C. M.

doi:10.1023/a:1008621505708

Cited by 146 publications

(11 citation statements)

References 33 publications

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“…Previous work by D’Mello et al [57] reported that production of the trichothecene mycotoxin 3ADON by F. culmorum was affected by the sterol biosynthesis inhibiting fungicide difenoconazole resistance. A higher mycotoxin production (T-2 toxin, 4,15-diacetoxyscirpenol, and neosolaniol) has also been found in a carbendazim resistant strain of F. sporotrichioides [58]. Zhang et al [59] found that mutants at codon 167 involved in carbendazim resistance produced significantly more trichothecenes than their wild-type progenitor did.…”

Section: Resultsmentioning

confidence: 99%

Genetic Relationships, Carbendazim Sensitivity and Mycotoxin Production of the Fusarium Graminearum Populations from Maize, Wheat and Rice in Eastern China

Qiu

Shi

2014

Toxins

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Members of the Fusarium graminearum species complex (FGSC) are important pathogens on wheat, maize, barley, and rice in China. Harvested grains are often contaminated by mycotoxins, such as the trichothecene nivalenol (NIV) and deoxynivalenol (DON) and the estrogenic mycotoxin zearalenone (ZEN), which is a big threat to humans and animals. In this study, 97 isolates were collected from maize, wheat, and rice in Jiangsu and Anhui provinces in 2013 and characterized by species- and chemotype-specific PCR. F. graminearum sensu stricto (s. str.) was predominant on maize, while most of the isolates collected from rice and wheat were identified as F. asiaticum. Fusarium isolates from three hosts varied in trichothecene chemotypes. The 3-acetyldeoxynivalenol (3ADON) chemotype predominated on wheat and rice population, while 15ADON was prevailing in the remaining isolates. Sequence analysis of the translation elongation factor 1α and trichodiene synthase indicated the accuracy of the above conclusion. Additionally, phylogenetic analysis suggested four groups with strong correlation with species, chemotype, and host. These isolates were also evaluated for their sensitivity to carbendazim and mycotoxins production. The maize population was less sensitive than the other two. The DON levels were similar in three populations, while those isolates on maize produced more ZEN. More DON was produced in carbendazim resistant strains than sensitive ones, but it seemed that carbendazim resistance had no effect on ZEN production in wheat culture.

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Section: Resultsmentioning

confidence: 99%

Genetic Relationships, Carbendazim Sensitivity and Mycotoxin Production of the Fusarium Graminearum Populations from Maize, Wheat and Rice in Eastern China

Qiu

Shi

2014

Toxins

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“…An increment of mycotoxins biosynthesis like that caused by fraction F6-1, has been reported (Suárez-Jiménez et al 2007;López et al 2004). D 0 Mello et al (1998) reported that at sublethal doses of some fungicides, mycotoxin production from Fusarium phytopathogenus may increase. Under laboratory conditions, other fungicides have shown to increase aflatoxin production by A. parasiticus.…”

Section: Discussionmentioning

confidence: 99%

“…Under laboratory conditions, other fungicides have shown to increase aflatoxin production by A. parasiticus. Moreover, increased production of the more toxic aflatoxin B 1 (D 0 Mello et al 1998). The overexpression of mycotoxin production could due to the physiological responses of the fungi to the stressful environment generated by the plant extract.…”

Section: Discussionmentioning

confidence: 99%

The effect of Baccharis glutinosa extract on the growth of mycotoxigenic fungi and fumonisin B1 and aflatoxin B1 production

Rosas‐Burgos

Cortez-Rocha

Plascencia‐Jatomea

et al. 2010

World J Microbiol Biotechnol

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The aim of this study was to evaluate the effect of Baccharis glutinosa isolated extract on the growth of Aspergillus flavus and Aspergillus parasiticus, and their aflatoxin B 1 production; and growth of Fusarium verticillioides, and their fumonisin B 1 production. The three fungi were exposed to an antifungal fraction, designated as fraction F6-1, isolated from B. glutinosa by methanolic extraction followed by silica gel chromatography. The growth of the fungi was evaluated in kinetics of radial extension growth, kinetics of spores germination, length and diameter of hyphae, spores diameter, as well as in aflatoxin B 1 and fumonisin B 1 production. Fraction F6-1 caused radial growth inhibition of the three fungi mainly F. verticillioides. Spores germination of A. flavus and A. parasiticus was delayed in the early stage of the incubation time, although they completely germinated at 27 h. In contrast, spore germination of F. verticillioides was inhibited 87.7% up to 96 h. The lengths and diameters of hyphae, and spore diameters of the three fungi, were significantly smaller in comparison with those of the controls, and several morphological alterations were observed. Concerning aflatoxin B 1 and fumonisin B 1 , fraction F6-1 did not show any inhibition effect at the concentration used. Fraction F6-1 was able to significantly inhibit the development of the three fungi, mainly F. verticillioides. The strong inhibitory effect of F6-1 on hyphae and spores suggests that it interacted with the fungi cell walls, which caused severe deformities. Nevertheless, this fraction was unable in inhibiting mycotoxin production from the three fungi at the concentration tested.

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“…Several authors have described that sublethal concentrations of fungicides trigger thrichothecene biosynthesis [21-23]. Others report opposite results [24,25].…”

Section: Introductionmentioning

confidence: 99%

Hydrogen peroxide induced by the fungicide prothioconazole triggers deoxynivalenol (DON) production by Fusarium graminearum

et al. 2010

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BackgroundFusarium head blight is a very important disease of small grain cereals with F. graminearum as one of the most important causal agents. It not only causes reduction in yield and quality but from a human and animal healthcare point of view, it produces mycotoxins such as deoxynivalenol (DON) which can accumulate to toxic levels. Little is known about external triggers influencing DON production.ResultsIn the present work, a combined in vivo/in vitro approach was used to test the effect of sub lethal fungicide treatments on DON production. Using a dilution series of prothioconazole, azoxystrobin and prothioconazole + fluoxastrobin, we demonstrated that sub lethal doses of prothioconazole coincide with an increase in DON production 48 h after fungicide treatment. In an artificial infection trial using wheat plants, the in vitro results of increased DON levels upon sub lethal prothioconazole application were confirmed illustrating the significance of these results from a practical point of view. In addition, further in vitro experiments revealed a timely hyperinduction of H2O2 production as fast as 4 h after amending cultures with prothioconazole. When applying H2O2 directly to germinating conidia, a similar induction of DON-production by F. graminearum was observed. The effect of sub lethal prothioconazole concentrations on DON production completely disappeared when applying catalase together with the fungicide.ConclusionsThese cumulative results suggest that H2O2 induced by sub lethal doses of the triazole fungicide prothioconazole acts as a trigger of DON biosynthesis. In a broader framework, this work clearly shows that DON production by the plant pathogen F. graminearum is the result of the interaction of fungal genomics and external environmental triggers.

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Cited by 146 publications

References 33 publications

Genetic Relationships, Carbendazim Sensitivity and Mycotoxin Production of the Fusarium Graminearum Populations from Maize, Wheat and Rice in Eastern China

Genetic Relationships, Carbendazim Sensitivity and Mycotoxin Production of the Fusarium Graminearum Populations from Maize, Wheat and Rice in Eastern China

The effect of Baccharis glutinosa extract on the growth of mycotoxigenic fungi and fumonisin B1 and aflatoxin B1 production

Hydrogen peroxide induced by the fungicide prothioconazole triggers deoxynivalenol (DON) production by Fusarium graminearum

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