1998
DOI: 10.1023/a:1006835526608
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Abstract: Isoproterenol hydrochloride (ISO), a beta adrenergic agonist, is known to cause ischemic necrosis in rats. Cardiotoxicity of three different doses of ISO were studied using physiological, biochemical and histopathological parameters. The effects of single and double dose of ISO were analysed, which illustrated that single ISO dose was more cardiotoxic than double ISO dose due to ischemic preconditioning. The tetrapeptide derivatives L-lysine-L-arginine-L-aspartic acid-L-serine (tetrapeptide A) and di-tert.buty… Show more

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Cited by 18 publications
(8 citation statements)
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“…Heart weight to body weight ratio was calculated as described earlier (Ramesh et al, 1998). Ventricles were harvested, cut and aliquoted into two separate tubes.…”
Section: Experimental Design and Protocolmentioning
confidence: 99%
“…Heart weight to body weight ratio was calculated as described earlier (Ramesh et al, 1998). Ventricles were harvested, cut and aliquoted into two separate tubes.…”
Section: Experimental Design and Protocolmentioning
confidence: 99%
“…This sequence, situated near the N-terminal region of the protein and known to inhibit platelet aggregation in in vitro condi- Vol. 48, 1999 Modulation of neutrophil function by a tetrapeptide 483 tions [33], has been suitably modified with hydrophobic groups (PEP 1261) to enhance the permeability across the membrane and also to increase the stability [9,10]. Experiments performed earlier to assess the effect of PEP 1261 on lymphocyte proliferation both in human peripheral blood mononuclear cells and rat splenic lymphocytes, show inhibition of lymphocyte proliferation in a dose dependent manner (unpublished data).…”
Section: Discussionmentioning
confidence: 99%
“…PEP 1261 used in this study was synthesized by solution phase methodology as represented schematically in scheme 1 and purified by column chromatography [9,10]. The homogeneity of the peptide was established by thin layer chromatography.…”
Section: Pep 1261mentioning
confidence: 99%
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