Our main goal in the current research work is to explore proofs of newly discovered theorems related to tempered fractional calculus. We use a new mechanism, namely, the natural tempered fractional transformation method, which can be used to solve important tempered fractional differential equations that are important in science, such as the linear and nonlinear tempered fractional differential equations. Indeed, we found new exact solutions to both tempered fractional Langevin and Vasicek differential equations and an exact solution for the famous tempered fractional diffusion equation. The new method makes it easier to do the calculations than with the traditional methods, and all you need is a few simple manipulations. Our new research technique is straightforward to use and highly accurate.