Vaccination of children following a previous hypotonic–hyporesponsive episode

Abstract

Previously healthy children who experience HHE reactions can safely continue standard vaccination schedules.

Eventos adversos pós-vacina contra a difteria, coqueluche e tétano e fatores associados à sua gravidade

“…The intensity of its clinical condition, even knowing that all the patients affected achieved recovery, makes it possible to infer that this has an impact on adherence to DPT vaccination. 6,15 HHE is considered to be an AEFV that is typically associated with the DPT vaccine, even though it has been associated with other vaccines. 6,15 In Brazil, its occurrence is a contraindication for subsequent doses of the whole-cell DPT vaccine and its replacement by the acellular type.…”

“…6,15 HHE is considered to be an AEFV that is typically associated with the DPT vaccine, even though it has been associated with other vaccines. 6,15 In Brazil, its occurrence is a contraindication for subsequent doses of the whole-cell DPT vaccine and its replacement by the acellular type. Although there have been reports of cases of HHE following application of the acellular (DPaT) and double child (DC) types of DPT vaccine, the frequency of this event under these circumstances has been found to be lower.…”

“…18,21 The biological plausibility of this result in relation to HHE cannot easily be discussed, since its physiopathogenesis has not been perfectly established. 6,15 Since the comparison group for analyzing factors associated with the severity of AEFV was children presenting mild forms of AEFV and not children without these events, the associations may have been underestimated.…”

Risk of Recurrence of Adverse Events Following Immunization: A Systematic Review

“…44,45,53,54 In this review, researchers reported a risk of recurrence after DTaP ±Hib/ HepB/IPV and DTwP vaccines of <0.8% in all the studies that included patients with HHE. 5,29,31,32 However, the risk of recurrence after DTwP combined with Hib, injectable poliomyelitis, or HepB antigens, which is currently used in low-and middle-income countries, was not evaluated.…”

Immunisation adverse events clinics

“…Such inpatient observation has proved very useful in encouraging re-vaccination after previous convulsions, HHEs, or apparent life-threatening events. 10 Children vaccinated at the Immunisation Adverse Events Clinic are routinely followed-up with a telephone interview 72 hours later, to ascertain any AEFI that may have occurred after vaccination.…”