Vaccination of Wildlife against Rabies: Successful Use of a Vectored Vaccine Obtained by Recombinant Technology

Maćkowiak, Maria; Maki, Joanne; Motes-Kreimeyer, L; Harbin, T; Kampen, Kaitlyn Van

doi:10.1016/s0065-3519(99)80043-3

Cited by 61 publications

(25 citation statements)

References 7 publications

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“…Recently, vaccination programs have shown promise for controlling some diseases in wildlife, including rabies (MacInnes et al 2001), sylvatic plague (Mencher et al 2004), and bovine tuberculosis (Roberts 1996). Rabies control programs, in particular, have used the landscape-scale distribution of vaccine-laden baits to control or eliminate rabies over extremely large areas in North America and Europe (Mackowiak et al 1999, MacInnes et al 2001. In 2009, for example, the National Rabies Management Program and their cooperators distributed approximately 6.5 million vaccine baits in 15 states in ongoing efforts to halt the spread of raccoon (Procyon lotor)-variant rabies (United States Department of Agriculture 2009).…”

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confidence: 99%

A comparison of methods for estimating raccoon abundance: Implications for disease vaccination programs

et al. 2012

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Accurate estimates of demographic parameters are critical to the management of wildlife populations, including management programs focused on controlling the spread of zoonotic diseases. Rabies managers in the United States Department of Agriculture (USDA) have applied a simple raccoon (Procyon lotor) abundance index (RAI) based on cumulative catch of unique raccoons per unit area to determine vaccine‐bait distribution densities. This approach was designed to allow for both the collection of biological samples and to index raccoon abundance to determine bait densities for oral rabies programs. However, post‐baiting surveillance data indicate that, on average, only 30% of raccoons sampled have vaccine induced rabies antibody titers, suggesting that bait densities may not be well calibrated to raccoon densities. We trapped raccoons using both capture‐mark‐recapture (CMR) and the standard RAI to evaluate the accuracy of the current index‐based methodology for estimating raccoon density. We then developed a resource selection function from spatial data collected from radio‐collared raccoons to standardize trap placement within the existing RAI protocol, and evaluated the performance of this modified RAI approach relative to CMR for estimating raccoon population size. Both abundance and density estimates derived using the RAI consistently underestimated raccoon population sizes compared with CMR methods. Similarly, although the use of resource selection models to inform trap placement appeared to improve the accuracy of the RAI, the effectiveness of this method was inconsistent because of an inability to account for variance in detection probabilities. Despite the logistical advantages of using indices to estimate population parameters to determine vaccine bait distribution densities, our results suggest that adjustments may be necessary to more accurately quantify raccoon abundance, which should improve the effectiveness of rabies management in the United States. In particular, estimates of detection probabilities are needed to more precisely quantify abundance estimates and ensure appropriate vaccine coverage rates. © 2012 The Wildlife Society.

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A comparison of methods for estimating raccoon abundance: Implications for disease vaccination programs

et al. 2012

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“…In addition, we used the same stock of VV that was used to develop V-RG, the rVV vaccine expressing the glycoprotein of Rabies virus. Extensive use of V-RG in Europe and North America to eradicate sylvatic rabies has generated an outstanding safety and efficacy record (18,25,26).…”

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Long-Term Sterilizing Immunity to Rinderpest in Cattle Vaccinated with a Recombinant Vaccinia Virus Expressing High Levels of the Fusion and Hemagglutinin Glycoproteins

Verardi

Aziz

Ahmad

et al. 2002

J Virol

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Rinderpest is an acute and highly contagious viral disease of ruminants, often resulting in greater than 90% mortality. We have constructed a recombinant vaccinia virus vaccine (v2RVFH) that expresses both the fusion (F) and hemagglutinin (H) genes of rinderpest virus (RPV) under strong synthetic vaccinia virus promoters. v2RVFH-infected cells express high levels of the F and H glycoproteins and show extensive syncytium formation. Cattle vaccinated intramuscularly with as little as 10 3 PFU of v2RVFH and challenged 1 month later with a lethal dose of RPV were completely protected from clinical disease; the 50% protective dose was determined to be 10 2 PFU. Animals vaccinated with v2RVFH did not develop pock lesions and did not transmit the recombinant vaccinia virus to contact animals. Intramuscular vaccination of cattle with 10 8 PFU of v2RVFH provided long-term sterilizing immunity against rinderpest. In addition to being highly safe and efficacious, v2RVFH is a heat-stable, inexpensive, and easily administered vaccine that allows the serological differentiation between vaccinated and naturally infected animals. Consequently, mass vaccination of cattle with v2RVFH could eradicate rinderpest.

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“…The earliest vector for delivery of a heterologous antigen is a licensed veterinary vaccine employing a MVA (Modified Vaccinia Ankara) vector to deliver a rabies antigen (Mackowiak et al, 1999). The vaccine was developed for delivery as bait for wild animals.…”

Section: Poxviruses As Gm Vaccine Vectorsmentioning

confidence: 99%

Genetically Engineered Virus-Vectored Vaccines – Environmental Risk Assessment and Management Challenges

Myhr¹,

Traavik²

2012

Genetic Engineering - Basics, New Applications and Responsibilities

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Vaccination of Wildlife against Rabies: Successful Use of a Vectored Vaccine Obtained by Recombinant Technology

Cited by 61 publications

References 7 publications

A comparison of methods for estimating raccoon abundance: Implications for disease vaccination programs

A comparison of methods for estimating raccoon abundance: Implications for disease vaccination programs

Long-Term Sterilizing Immunity to Rinderpest in Cattle Vaccinated with a Recombinant Vaccinia Virus Expressing High Levels of the Fusion and Hemagglutinin Glycoproteins

Genetically Engineered Virus-Vectored Vaccines – Environmental Risk Assessment and Management Challenges

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