Vaccination with gamma radiation-attenuated <i>Toxoplasma gondii</i> protects against ovarian infiltration in mice-bearing Ehrlich ascites carcinoma

Hafez, E.N.; Youssef, Hanan Mohamed Gabr; El-kabany, Hanan Ahmed

doi:10.1080/09553002.2020.1739772

Cited by 5 publications

(5 citation statements)

References 35 publications

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“…12 Recent model using gamma radiationattenuated T gondii ME49 vaccine has been demonstrated immune protection against ovarian infiltration in micebearing Ehrlich ascites carcinoma (EAC). 13 Hence, this study aimed to evaluate the antitumor modality of gamma radiation-attenuated T gondii as a proapoptotic and antiangiogenic regulator in liver tissues of EAC-bearing mice.…”

Section: Introductionmentioning

confidence: 99%

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Gamma Radiation-Attenuated Toxoplasma gondii Provokes Apoptosis in Ehrlich Ascites Carcinoma-Bearing Mice Generating Long-Lasting Immunity

Hafez

Moawed

Abdel-Hamid

et al. 2020

Technol Cancer Res Treat

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Purpose: Pathological angiogenesis and apoptosis evasions are common hallmarks of cancer. A different approach to the antitumor effect of parasitic diseases caused by certain protozoans and helminthes had been adopted in recent years as they can affect many cancer characteristics. The present work is an attempt to assess the effect of gamma radiation-attenuated Toxoplasma gondii ME49 as an antiapoptotic and angiogenic regulator modifier on tumor growth aimed at improving cancer protective protocols. Methods: Attenuated Toxoplasma gondii ME49 was administered orally to mice 2 weeks before inoculation with Ehrlich ascites carcinoma to allow stimulation of the immune response. Hepatic histopathology and immune responses were determined for each group. Results: Marked suppression of the tumor proliferation with induction of long-lasting immunity by stimulating interferon γ and downregulating transforming growth factor β. The level of tumor promoting inflammatory markers (STAT-3 and tumor necrosis factor α), the angiogenic factors (vascular endothelial growth factor A, integrin, and matrix metallopeptidase 2 and matrix metallopeptidase 9), as well as nitric oxide concentration were significantly decreased. This was collimated with an improvement in apoptotic regulators (cytochrome-c, Bax, Bak, and caspase 3) in liver tissues of vaccinated mice group compared to Ehrlich ascites carcinoma-bearing one. Moreover, the histopathological investigations confirmed this improvement. Conclusion: Hence, there is an evidence of potency of radiation attenuated Toxoplasma vaccine in immune activation and targeting tumor cell that can be used as a prophylactic or an adjuvant in combination with chemotherapeutic drugs.

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Section: Introductionmentioning

confidence: 99%

“…12 Recent model using gamma radiation-attenuated T gondii ME49 vaccine has been demonstrated immune protection against ovarian infiltration in mice-bearing Ehrlich ascites carcinoma (EAC). 13…”

Section: Introductionmentioning

confidence: 99%

Gamma Radiation-Attenuated Toxoplasma gondii Provokes Apoptosis in Ehrlich Ascites Carcinoma-Bearing Mice Generating Long-Lasting Immunity

Hafez

Moawed

Abdel-Hamid

et al. 2020

Technol Cancer Res Treat

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“…In this regard, Salanti et al displayed that a glycosaminoglycan protein of Plasmodium falciparum binds selectively to cancer cells (20). Also, attenuated T. gondii Me49 induced a strong cell-mediated antitumor immune response causing immune protection against primary cancer development (21).…”

Section: Discussionmentioning

confidence: 99%

Human Anti-Toxoplasma Antibodies Attach Strongly to Breast Cancer Cells

Hosseini,

Farahbakhsh,

Balouti

et al. 2023

Int J Cancer Manag

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Background: Toxoplasma gondii (T. gondii) is the most common intracellular parasite in the human population. The anti-cancer effect of these parasites has been shown, which may be due to the presence of common antigens between the parasite and cancer cells. Objectives: In this work, the reaction of Toxoplasma-positive human sera and Toxoplasma-negative human sera with cell surfaces of 4T1 and MCF7 cell lines have been investigated. Methods: 4T1 and MCF7 cells were harvested from cell cultures and treated with either human Toxoplasma Positive or negative sera. The reaction of the sera was then detected using the flow cytometry method. Results: Toxoplasma-positive sera but not Toxoplasma-negative ones reacted very sharply with both breast cancer cell lines. Conclusions: Anti-T. gondii antibodies strongly react with breast cancer cells. These antibodies may be used for selective cancer immunotherapy in the future.

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“…Moreover, intratumoral injection of ΔGRA17 strains were found to interact synergically with programmed cell death 1 ligand 1 checkpoint inhibitors to improve anti-tumor activity in several kinds of tumors ( Zhu et al., 2021 ). Additionally, oral feeding of the gamma radiation-attenuated strains could promote the secretion of IL-12 and IFN-γ in tumor-bearing mice ( Hafez et al., 2020a ; Hafez et al., 2020b ). All these effects contribute to the elimination of tumor cells and inhibition of progression.…”

Section: T Gondiimentioning

confidence: 99%

A novel enemy of cancer: recent investigations into protozoan anti-tumor properties

Zheng,

Lu,

Zhou

et al. 2024

Front. Cell. Infect. Microbiol.

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Cancer remains a significant global health issue, despite advances in screening and treatment. While existing tumor treatment protocols such as surgery, chemotherapy, radiotherapy, targeted therapy, and immunotherapy have proven effective in enhancing the prognosis for some patients, these treatments do not benefit all patients. Consequently, certain types of cancer continue to exhibit a relatively low 5-year survival rate. Therefore, the pursuit of novel tumor intervention strategies may help improve the current effectiveness of tumor treatment. Over the past few decades, numerous species of protozoa and their components have exhibited anti-tumor potential via immune and non-immune mechanisms. This discovery introduces a new research direction for the development of new and effective cancer treatments. Through in vitro experiments and studies involving tumor-bearing mice, the anti-tumor ability of Toxoplasma gondii, Plasmodium, Trypanosoma cruzi, and other protozoa have unveiled diverse mechanisms by which protozoa combat cancer, demonstrating encouraging prospects for their application. In this review, we summarize the anti-tumor ability and anti-tumor mechanisms of various protozoa and explore the potential for their clinical development and application.

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Vaccination with gamma radiation-attenuated Toxoplasma gondii protects against ovarian infiltration in mice-bearing Ehrlich ascites carcinoma

Cited by 5 publications

References 35 publications

Gamma Radiation-Attenuated Toxoplasma gondii Provokes Apoptosis in Ehrlich Ascites Carcinoma-Bearing Mice Generating Long-Lasting Immunity

Gamma Radiation-Attenuated Toxoplasma gondii Provokes Apoptosis in Ehrlich Ascites Carcinoma-Bearing Mice Generating Long-Lasting Immunity

Human Anti-Toxoplasma Antibodies Attach Strongly to Breast Cancer Cells

A novel enemy of cancer: recent investigations into protozoan anti-tumor properties

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