Vaccination with the Inactivated Vaccine (Sinopharm BBIBP-CorV) Ensures Protection against SARS-CoV-2 Related Disease

Wang, Chao; Chen, Lin‐Yi; Lu, Qing‐Bin; Cui, Fuqiang

doi:10.3390/vaccines10060920

Cited by 22 publications

(14 citation statements)

References 23 publications

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“…COV2.S [J&J/Janssen]), and inactivated vaccines (e.g., CoronaVac [Sinovac]) [12]. It is reported that the inactivated COVID-19 vaccines most widely used in China (e.g., BBIBP--CorV and CoronaVac) have a less effectiveness (66%-78%) [13,14] than the mRNA vaccines (BNT162b2 and mRNA-1273, >90%) used in Western countries [15,16]. Despite the proven effectiveness of COVID-19 vaccines in preventing severe COVID-19 outcomes, the global vaccination coverage remains far below expectations [17].…”

Section: Introductionmentioning

confidence: 99%

Perceived health literacy and COVID-19 vaccine acceptance among Chinese college students: A mediation analysis

et al. 2022

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Background Although COVID-19 vaccines hold the potential to dramatically alter the COVID-19 pandemic, vaccine hesitancy remains a serious threat to the management and control of COVID-19 infections. Vaccination of young adults plays a crucial role in achieving herd immunity. However, the determinants of COVID-19 vaccine acceptance among the youth in China have not been fully explored. Our study aims to investigate the direct and indirect effects of perceived health literacy on COVID-19 vaccine acceptance. Methods This survey was conducted among Chinese college students during September and October, 2020. COVID-19 vaccine acceptance was defined as the likelihood that participants would get a COVID-19 vaccine. A mediation analysis was employed to explore the direct and indirect effects of perceived health literacy on COVID-19 vaccine acceptance. Results A total of 2,587 college students were included in our study. The results of the survey revealed that the majority (80.40%) of the participants expressed high COVID-19 vaccine acceptance. After controlling for demographic characteristics, the relationship between perceived health literacy and COVID-19 vaccine acceptance was mediated by positive attitudes toward general vaccination (std.β = 0.004, p = 0.037) and self-efficacy of COVID-19 vaccine (std.β = 0.053, p < 0.001). Conclusions The findings suggest that interventions targeting health literacy to promote COVID-19 vaccination coverage might consider placing greater emphasis on enhancing the positive attitude towards and self-efficacy of vaccines among youth.

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Section: Introductionmentioning

confidence: 99%

Perceived health literacy and COVID-19 vaccine acceptance among Chinese college students: A mediation analysis

et al. 2022

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“…The period studied was alpha and then delta variants were predominant leading to a peak in morbidity and mortality by June 2021 (63). Whilst BBIBP-CorV vaccination been shown to be effective in reducing hospitalization and symptomatic COVID-19, it is also shown that induced levels of IgG to RBD are lower than other vaccinations and therefore booster vaccinations are recommended (64, 65).…”

Section: Discussionmentioning

confidence: 99%

BBIBP-CorV (Sinopharm) vaccination- induced immunity is affected by age, gender and prior COVID-19 and activates responses to spike and other antigens

Hasan¹,

Masood²,

Qaiser³

et al. 2022

Preprint

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Long-term solutions against SARS-CoV-2 infections require understanding of immune protection induced by different vaccine COVID-19 formulations. We investigated humoral and cellular immunity induced by Sinopharm (BBIBP-CorV) in a region of high SARS-CoV-2 seroprevalence. Levels of IgG antibodies to SARS-CoV-2 spike protein and its receptor-binding domain (RBD) were determined 24-weeks. Cellular immunity was investigated using a commercially available IFN-γ release assay to SARS-CoV-2 spike (Ag1 and 2) and extended genome antigens (Ag3). Increasing IgG seropositivity to Spike protein and RBD was observed post-vaccination. Seropositivity was reduced in those over 50 years and raised in females and those with prior COVID-19. After 20 weeks post-vaccination, only one third of participants had positive T cell responses to SARS-CoV-2 antigens. Prior COVID-19 impacted IFNγ responses, with reactivity enhanced in those infected earlier. The frequency of IFNγ responses was highest to extended genome antigen set. Overall, BBIBP-CorV- induced antibody responses were impacted by age, gender and prior COVID-19. Cellular immunity was present in a limited number of individuals after 20 weeks but was enhanced by prior infection. This suggests the need for booster vaccinations in older individuals. BBIBP-CorV induced cellular activation is broader than to spike, requiring further study to understand how to monitor vaccine effectiveness.

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“…Developed in China, the inactivated whole-virus vaccine Sinopharm (Beijing, China) BBIBP-CorV, containing an aluminum hydroxide adjuvant, has been approved by the WHO for emergency use, and it has been distributed in more than 40 countries [ 70 ]. Another Chinese vaccine approved by the WHO is CoronaVac (Sinovac (Beijing, China)), an inactivated SARS-CoV-2 aluminum-hydroxide-adjuvanted vaccine created from African green monkey kidney cells (Vero cells) that have been inoculated with SARS-CoV-2 [ 71 , 72 ].…”

Section: Inactivated Whole-virus Vaccines and Alcoholmentioning

confidence: 99%

COVID-19 Vaccination and Alcohol Consumption: Justification of Risks

Solopov

2023

Pathogens

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Since the beginning of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, pharmaceutical companies and research institutions have been actively working to develop vaccines, and the mass roll-out of vaccinations against COVID-19 began in January 2021. At the same time, during lockdowns, the consumption of alcoholic beverages increased. During the peak of vaccination, consumption remained at high levels around the world, despite the gradual relaxation of quarantine restrictions. Two of the popular queries on search engines were whether it is safe to drink alcohol after vaccination and whether this will affect the effectiveness of vaccines. Over the past two years, many studies have been published suggesting that excessive drinking not only worsens the course of an acute respiratory distress syndrome caused by the SARS-CoV-2 virus but can also exacerbate post-COVID-19 syndrome. Despite all sorts of online speculation, there is no specific scientific data on alcohol-induced complications after vaccination in the literature. Most of the published vaccine clinical trials do not include groups of patients with a history of alcohol-use disorders. This review analyzed the well-known and new mechanisms of action of COVID-19 vaccines on the immune system and the effects of alcohol and its metabolites on these mechanisms.

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Vaccination with the Inactivated Vaccine (Sinopharm BBIBP-CorV) Ensures Protection against SARS-CoV-2 Related Disease

Cited by 22 publications

References 23 publications

Perceived health literacy and COVID-19 vaccine acceptance among Chinese college students: A mediation analysis

Perceived health literacy and COVID-19 vaccine acceptance among Chinese college students: A mediation analysis

BBIBP-CorV (Sinopharm) vaccination- induced immunity is affected by age, gender and prior COVID-19 and activates responses to spike and other antigens

COVID-19 Vaccination and Alcohol Consumption: Justification of Risks

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