Vaccinations in hematological patients in the era of target therapies: Lesson learnt from SARS-CoV-2

Fattizzo, Bruno; Rampi, Nicolò; Barcellini, Wilma

doi:10.1016/j.blre.2023.101077

Cited by 4 publications

(3 citation statements)

References 140 publications

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“…During the COVID-19 pandemic, a large proportion of vaccine failures occurred in the ESRD population, indicating the dysfunction of adaptive immunity among these patients. 17,18 In this study, we also clarified the decreased number and percentage of B cells, which was positively related to the serum ferritin level. Ferritin has been identified as a biomarker of iron overload, inflammation, and malignancy and is thus associated with uremic cardiomyopathy and elevated allcause mortality.…”

Section: Discussionmentioning

confidence: 68%

Identification of Cell-Cell Communications by Single-Cell RNA Sequencing in End Stage Renal Disease Provides New Insights into Immune Cell Heterogeneity

Zhang,

Liu,

et al. 2023

JIR

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Objective Impaired immune system characterized by low-grade inflammation is closely associated with kidney chronic kidney disease (CKD) progression. To reveal the alterations of the function, component, and intercellular communication of immune cells during the progression of CKD. Patients and Methods We conducted a case-control study enrolling regular hemodialysis patients and healthy controls. Clinical data, serum and peripheral blood mononuclear cell (PBMC) samples were collected. Flow cytometry and single-cell RNA sequencing were performed to quantitatively analyze the immune cell subsets and T-cell subsets of PBMCs. scRNA data of GSE140023 containing mouse unilateral ureteral obstruction (UUO) models were analyzed the heterogeneity of immune cells. Results Overall reduction in peripheral blood lymphocyte subsets in patients with end-stage renal disease (ESRD) was observed. A higher ratio of Th17/Treg, Th1/Treg, and b-cell/Treg in the ESRD group was associated with a decrease in eGFR, PTH, and ferritin. Among T cell subsets identified by scRNA analysis, Th17 cells were significantly increased in the ESRD and UU0 group. TFH, Th1, and Th2 cells are located at the final stage in the developmental tree, while Treg and memory CD8+ T cells are at the beginning site. Early developmental differentiation of Th17, Th1, and Tfh cells was observed in the ESRD and UUO group. Analysis of intercellular communication between t-cell subpopulations identified two major input and output signaling pathways: the CD40 and macrophage inhibitory factor (MIF) pathways. The MIF signaling pathway primarily mediates intercellular communication among th17 effects, CD8+ t-cell, and Th17-Treg in the ESRD group, the serum level of MIF showed significant upregulation, which was closely related to Th17/Treg cells. Conclusions A global immune imbalance was closely associated with the deterioration in renal function and complication development. The MIF signaling pathway mediates Th17/Treg communication and promotes the trans-differentiation of Treg cells to Th17 cells in CKD progression.

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Section: Discussionmentioning

confidence: 68%

Identification of Cell-Cell Communications by Single-Cell RNA Sequencing in End Stage Renal Disease Provides New Insights into Immune Cell Heterogeneity

Zhang,

Liu,

et al. 2023

JIR

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“…The timing of CD20 inhibitors therapies is an important factor to consider for vaccine-induced response. Indeed, it has been shown that if COVID-19 vaccination is performed during the treatment, the rate of seroconversion is not impacted; on the other hand, if vaccination is performed after treatment completion or within 12 months, an improvement from 40 to 70% is observed [ 84 ]. In contrast, vaccine-induced T-cell response is less impaired by CD20 inhibitors [ 83 ].…”

Section: Current Views On Sars-cov-2-specific T-cell Responsesmentioning

confidence: 99%

“…In contrast, vaccine-induced T-cell response is less impaired by CD20 inhibitors [ 83 ]. Indeed, even if the T-cell response is observed mainly in seroconverted patients [ 85 ] and was less associated with the time from the last CD20 inhibitors dose administration [ 84 ], it may be detected even in the absence of a detectable humoral response [ 74 ], supporting the benefit of vaccination even in the case of these therapies. Moreover, like patients with HSCT, booster vaccination doses have been suggested for patients with hematologic malignancies [ 80 ].…”

Section: Current Views On Sars-cov-2-specific T-cell Responsesmentioning

confidence: 99%

The Importance of Measuring SARS-CoV-2-Specific T-Cell Responses in an Ongoing Pandemic

et al. 2023

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Neutralizing antibodies are considered a correlate of protection against SARS-CoV-2 infection and severe COVID-19, although they are not the only contributing factor to immunity: T-cell responses are considered important in protecting against severe COVID-19 and contributing to the success of vaccination effort. T-cell responses after vaccination largely mirror those of natural infection in magnitude and functional capacity, but not in breadth, as T-cells induced by vaccination exclusively target the surface spike glycoprotein. T-cell responses offer a long-lived line of defense and, unlike humoral responses, largely retain reactivity against the SARS-CoV-2 variants. Given the increasingly recognized role of T-cell responses in protection against severe COVID-19, the circulation of SARS-CoV-2 variants, and the potential implementation of novel vaccines, it becomes imperative to continuously monitor T-cell responses. In addition to “classical” T-cell assays requiring the isolation of peripheral blood mononuclear cells, simple whole-blood-based interferon-γ release assays have a potential role in routine T-cell response monitoring. These assays could be particularly useful for immunocompromised people and other clinically vulnerable populations, where interactions between cellular and humoral immunity are complex. As we continue to live alongside COVID-19, the importance of considering immunity as a whole, incorporating both humoral and cellular responses, is crucial.

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Vaccinations in patients with chronic lymphocytic leukemia

Francis,

Vu,

Perez

et al. 2024

Seminars in Hematology

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Vaccinations in hematological patients in the era of target therapies: Lesson learnt from SARS-CoV-2

Cited by 4 publications

References 140 publications

Identification of Cell-Cell Communications by Single-Cell RNA Sequencing in End Stage Renal Disease Provides New Insights into Immune Cell Heterogeneity

Identification of Cell-Cell Communications by Single-Cell RNA Sequencing in End Stage Renal Disease Provides New Insights into Immune Cell Heterogeneity

The Importance of Measuring SARS-CoV-2-Specific T-Cell Responses in an Ongoing Pandemic

Vaccinations in patients with chronic lymphocytic leukemia

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