Vaccine preventable diseases, vaccine hesitancy, and COVID-19: A role for the allergist/immunologist

Bellanti, Joseph A.; Settipane, Russell A.

doi:10.2500/aap.2021.42.210070

Cited by 3 publications

(1 citation statement)

References 27 publications

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“…Studies have reported vaccine hesitancy in 13.4%, 19.4%, and 17.8% of patients with cancer, autoimmune diseases, and chronic lung diseases, respectively (6), despite expert opinions that the benefits of being vaccinated outweigh the limitations of available evidence for a specific high-risk group (7)(8)(9)(10). Moreover, vaccine resistance appears to correlate with geographic location, country-specific regulations of vaccines availability, the proposed vaccination schedule, study methodologies, the study period in relation to the pandemic wave, and evolving vaccine safety and efficacy data (1,(11)(12)(13)(14)(15)(16). For example, 54% of patients with autoimmune inflammatory rheumatic diseases (AIIRDs) initially accepted the idea of COVID-19 vaccinations (17).…”

Section: Introductionmentioning

confidence: 99%

Coronavirus disease 2019 vaccination uptake and hesitancy among Polish patients with inborn errors of immunity, autoinflammatory syndromes, and rheumatic diseases: A multicenter survey

Więsik-Szewczyk

Ziętkiewicz²,

Będzichowska³

et al. 2022

Front. Immunol.

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Data regarding the willingness of patients affected by inborn errors of immunity to accept vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are limited. Therefore, this study assessed SARS-CoV-2 vaccination coverage and hesitancy in immunodeficient patients by surveying adults with primary immune deficiencies and autoinflammatory and rheumatic diseases on biologic therapy. The study was conducted from September 20, 2021, to January 22, 2022, when the primary coronavirus disease 2019 (COVID-19) vaccinations were available to all adults in Poland. We included 207 participants consecutively recruited from five referral centers (57% female; median age: 42.6 [range: 18–76, standard deviation ± 14.70] years). Overall, 55% (n = 114), 17% (n = 36), and 28% (n = 57) of the patients had primary immune deficiencies, autoinflammatory diseases, and rheumatic diseases, respectively. Among the entire cohort, 168 patients (81%) were vaccinated, and 82% were willing to receive a booster dose. Patients with autoinflammatory diseases had the highest vaccination rate (94.4%). A strong conviction that it was the correct decision (72%), fear of getting COVID-19 (38%), and expert opinions (34%) influenced the decision to vaccinate. Among the unvaccinated patients, 33.3% had primary or vocational education (p <0.001). Furthermore, only 33% believed they were at risk of a severe course of COVID-19 (p = 0.014), and 10% believed in vaccine efficacy (p <0.001). They also doubted the safety of the vaccine (p <0.001) and feared a post-vaccination flare of their disease (p <0.001). Half of the unvaccinated respondents declared that they would consider changing their decision. Vaccination coverage in immunodeficient patients was higher than in the general Polish population. However, the hesitant patients doubted the vaccine’s safety, feared a post-vaccination disease flare, and had primary or vocational education. Therefore, vaccination promotion activities should stress personal safety and the low risk of disease flares due to vaccination. Furthermore, all evidence must be communicated in patient-friendly terms.

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Section: Introductionmentioning

confidence: 99%

Coronavirus disease 2019 vaccination uptake and hesitancy among Polish patients with inborn errors of immunity, autoinflammatory syndromes, and rheumatic diseases: A multicenter survey

Więsik-Szewczyk

Ziętkiewicz²,

Będzichowska³

et al. 2022

Front. Immunol.

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Psychological impacts of coronavirus disease 2019 on people with asthma, allergic rhinitis, and food allergy

Burrows

Ellis

2022

Annals of Allergy, Asthma & Immunology

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To summarize the current literature of the psychological impacts of coronavirus disease 2019 (COVID-19) on people with allergic diseases and to identify gaps in need of future research. Data Sources: Ovid MEDLINE(R) and Embase Classics + Embase from 1947 to present (October 18, 2021) were searched using a search strategy that included the following keywords: allergic diseases, covid*, and psychological disorders. Study Selections: Primary manuscripts and abstracts using online and telephone surveys, mixed-method studies capturing patient and caregiver experiences, case studies, and published guidelines from allergic disease-specific expert groups were included. Results: People with asthma and other chronic respiratory conditions are at higher risk of negative psychological outcomes, and risk factors include asthma severity, female sex, and previous history of anxiety and depression, likely owing to the perceived risk of severe disease from COVID-19. One study identified that people with allergic rhinitis had significantly high anxiety and depression scores compared with healthy controls (both, P < .001). The psychological impacts of food allergy during COVID-19 were most strongly felt by parents and caregivers. Similarly, parents of children with asthma experienced substantial psychological burden. Conclusion: COVID-19 had a considerable psychological impact on patients with asthma. Limited data have been published on the mental health impacts of COVID-19 on patients with allergic rhinitis and food allergy. As COVID-19 research continues to evolve and the literature captures later stages of the pandemic, it is important that physicians be aware of the potential coincidence of mental illness and chronic allergic diseases and refer these patients, and their caregivers, to appropriate resources while also continuing to manage their allergic disease(s).

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