Vaccine related itching nodules and hypersensitivity to aluminium

Trollfors, Birger; Bergfors, Elisabeth; Inerot, Annica

doi:10.1016/j.vaccine.2004.08.024

Cited by 11 publications

(9 citation statements)

References 2 publications

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“… 15 which included 54 HD patients. In the general population, persistent pruritus and itching nodules have been reported after the use of Al-containing vaccines 19 – 21 . Bergfors et al .…”

Section: Discussionmentioning

confidence: 99%

Association Between Serum Aluminum Level and Uremic Pruritus in Hemodialysis Patients

Hsu

Weng

Chan

et al. 2018

Sci Rep

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Uremic pruritus (UP) is a common symptom in patients undergoing hemodialysis (HD). The pathogenesis of UP is complex. Aluminum (Al) is a common metal and is toxic to patients undergoing HD. Al is also a known human allergen which can induce immune reactions. However, the correlation between Al and UP remains unclear in dialysis patients. A total of 866 patients on maintenance HD were enrolled for analysis. The HD patients with higher serum Al levels had higher a prevalence of UP than those with lower serum Al levels. After adjusting for confounding variables, the serum Al level was significantly associated with UP. Overall, each 10-fold increase in serum Al level was associated with a 5.64-fold increase in the risk of developing UP in these subjects. The results of this cross-sectional study suggest that serum Al level may be associated with the development of UP in patients on maintenance HD.

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Section: Discussionmentioning

confidence: 99%

Association Between Serum Aluminum Level and Uremic Pruritus in Hemodialysis Patients

Hsu

Weng

Chan

et al. 2018

Sci Rep

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“…This is crucial since systemic distribution of allergen could lead to adverse side‐effects such as anaphylactic reactions. However, there are drawbacks associated with alum as an adjuvant (4, 6, 24, 25), and therefore the use of CBP as a means to improve the allergen formulation for ASIT was assessed.…”

Section: Discussionmentioning

confidence: 99%

Carbohydrate‐based particles reduce allergic inflammation in a mouse model for cat allergy

Neimert-Andersson

Thunberg

Swedin

et al. 2008

Allergy

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“…Alum mainly acts via Th2 cellular immune response, which does not confer the best protection for viral infections such as HCV and HIV. Moreover, there are safety concerns with the use of alum as an adjuvant with reported cases of hypersensitivity and erythema ( 67 , 68 ). Well characterized agonists of innate immunity may serve as a better candidate of targeted vaccine adjuvants (Figure 2 ).…”

Section: Innate Immune Potentiator As Vaccine Adjuvantsmentioning

confidence: 99%

RIG-I-Like Receptors as Novel Targets for Pan-Antivirals and Vaccine Adjuvants Against Emerging and Re-Emerging Viral Infections

Yong

Luo

2018

Front. Immunol.

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Emerging and re-emerging viruses pose a significant public health challenge around the world, among which RNA viruses are the cause of many major outbreaks of infectious diseases. As one of the early lines of defense in the human immune system, RIG-I-like receptors (RLRs) play an important role as sentinels to thwart the progression of virus infection. The activation of RLRs leads to an antiviral state in the host cells, which triggers the adaptive arm of immunity and ultimately the clearance of viral infections. Hence, RLRs are promising targets for the development of pan-antivirals and vaccine adjuvants. Here, we discuss the opportunities and challenges of developing RLR agonists into antiviral therapeutic agents and vaccine adjuvants against a broad range of viruses.

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Vaccine related itching nodules and hypersensitivity to aluminium

Cited by 11 publications

References 2 publications

Association Between Serum Aluminum Level and Uremic Pruritus in Hemodialysis Patients

Association Between Serum Aluminum Level and Uremic Pruritus in Hemodialysis Patients

Carbohydrate‐based particles reduce allergic inflammation in a mouse model for cat allergy

RIG-I-Like Receptors as Novel Targets for Pan-Antivirals and Vaccine Adjuvants Against Emerging and Re-Emerging Viral Infections

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