Vacinação Contra a COVID-19 numa Rede de Clínicas de Hemodiálise em Portugal: Uma Experiência Promissora

Matos, João Fazendeiro; Peralta, Ricardo; Felix, Carla; Pinto, Bruno; Ponce, Pedro

doi:10.20344/amp.16250

Cited by 3 publications

(3 citation statements)

References 6 publications

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“…Significantly fewer patients were hospitalized following the second dose or the booster. This correlates with similar studies at other centers which suggest that vaccination resulted in a reduction in hospitalization for severe infections among dialysis patients, in particular, HD patients [43], although this has also been attributed to increased vaccine uptake in the general population and not only in the dialysis group [44,45]. Dialysis patients, particularly older patients, with a longer duration of ESKD have been found to have suboptimal antibody titers following vaccination [46,47].…”

Section: Discussionsupporting

confidence: 86%

COVID‐19 vaccine uptake rates, perceptions, and attitudes among dialysis patients: Experience across a national sample

et al. 2023

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Introduction: Dialysis patients are at increased risk of severe COVID-19 infection making vaccination a priority. We explored COVID-19 vaccine uptake and perceptions in our dialysis population, associated COVID-19 infection, and hospitalization rates.Methods: This is a single-center retrospective study using telephone questionnaires and hospital records to investigate COVID-19 vaccine uptake and attitudes behind vaccination status.Results: A total of 230 patients were interviewed. Vaccine uptake was 97.8% (two doses) and 86.6% (booster dose), with 79.5% vaccinated at Renal Unit.Most (58.5%) cited healthcare worker advice as a contributing factor and 54% sought protection through vaccination. COVID-19 hospitalization was higher in unvaccinated and patients vaccinated with one dose, compared to two doses (63.2% vs. 20%, p = 0.05) and booster dose (63.2% vs. 22.2%, p = 0.02). Conclusion: Our dialysis population recognized the importance of COVID-19 vaccination. Intensive patient education and easy access to the COVID-19 vaccine may have facilitated vaccine uptake in these patients.

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Section: Discussionsupporting

confidence: 86%

COVID‐19 vaccine uptake rates, perceptions, and attitudes among dialysis patients: Experience across a national sample

et al. 2023

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“…Vaccinated HD patients in Japan had lower mortality rates and oxygen requirements than unvaccinated patients 37 . Despite vaccination, mortality among HD patients in Portugal remained higher than that in the general population 38 . We could not evaluate the effect of vaccination in HD patients in our investigation because of the short follow-up time after vaccination, but mainly because it coincided with a decrease in cases in Peru, for which an additional study is necessary to evaluate this effectiveness.…”

Section: Discussionmentioning

confidence: 88%

Hospitalization and mortality during the pandemic in chronic hemodialysis patients and the general population in Peru

et al. 2023

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Background: Patients with chronic kidney disease have a higher risk of severe disease and mortality from COVID-19 than the general population. Objective: To compare hospitalization and mortality rates during the pandemic among chronic hemodialysis (HD) patients and the general population in Lima (Peru). Methods: This retrospective cohort included an assessment of the database of chronic HD patients of the health service providers of the social health insurance benefit networks of Lima and Callao between 2019 and 2021. Hospitalization and mortality rates were obtained for every 1,000 individuals, and variations in the percentages of COVID-19 cases and deaths were calculated. These rates were compared with those of the general population data and standardized by age and sex. Results: An average of 3,937 chronic HD patients were evaluated each month. Of these, 4.8% had COVID-19 and 64.97% were mild cases. The hospitalization rates per 1,000 patients were 19.5, 29.28, and 36.7 in 2019, 2020, and 2021, respectively. The mortality rates per 1,000 patients were 5.9, 9.74, and 11.49 in 2019, 2020, and 2021, respectively. When compared to the standardized general population, the peaks of both rates coincided with the plateaus of the waves during the pandemic. The hospitalization rate for COVID-19 was 12 times higher in HD patients than in the general population, and the mortality rate for COVID-19 was twice as high. Conclusion: HD patients had higher hospitalization and standardized mortality rates than the general population. Peaks in hospitalizations and mortality coincided with the plateaus of the first and second waves of the pandemic.

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“…According to the literature, this group of patients is five to sixteen times more likely to be infected with SARS-CoV-2 and has nearly a 30 to 130% higher risk of death than the general population [ 5 ]. Thus, prioritizing this particular group of patients for vaccination was a common strategy in several countries, like Portugal [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Vaccination against SARS-CoV-2 in Haemodialysis Patients: Spike’s Ab Response and the Influence of BMI and Age

Ponce¹,

Peralta²,

Felix³

et al. 2022

IJERPH

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Patients with chronic kidney disease (CKD-5D) in dialysis have been associated with higher rates of SARS-CoV-2 infection. Objective: To identify the CKD-5D patients’ immune system behavior regarding the Pfizer-BioNTech (BNT162b2 mRNA) vaccine (Comirnaty©). This was a multicenter study carried out in 38 dialysis units in NephroCare Portugal. Eligible patients from two cohorts—one composed of completely vaccinated patients with Comirnaty© (vaccinated group) against a second cohort of patients who recovered from SARS-CoV-2 infection (control group)—were selected through representative sampling for each cohort. Humoral response was assessed at 3 (t0) and 6 months (t1) after complete vaccination and, in the control group, 6 months after COVID-19 recovery. In the vaccinated group, at t0, the median anti-Spike IgG level was 1120 AU/mL and, at t1, all participants’ antibody level decreased to a median of 455 AU/mL. In the control group, the median serum SARS-CoV-2 antibodies level was 1836 AU/mL. In the vaccinated group, at t0, patients < 70 years presented a significantly (p = 0.002) higher level of anti-Spike IgG titres. In contrast, older patients from the control group presented a significantly (p = 0.038) higher IgG. No correlation was found between age and anti-Spike IgG antibodies level in any of the studied groups. Patients with a higher body mass index showed a greater immune response in both the vaccinated and control group, although without significance. We concluded that, in the vaccinated group, elderly patients developed a lower immune response than younger patients and the levels of anti-Spike IgG antibodies declined faster between t0 and t1, while in the control group, the oldest and overweight patients developed the best humoral response.

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Vacinação Contra a COVID-19 numa Rede de Clínicas de Hemodiálise em Portugal: Uma Experiência Promissora

Cited by 3 publications

References 6 publications

COVID‐19 vaccine uptake rates, perceptions, and attitudes among dialysis patients: Experience across a national sample

COVID‐19 vaccine uptake rates, perceptions, and attitudes among dialysis patients: Experience across a national sample

Hospitalization and mortality during the pandemic in chronic hemodialysis patients and the general population in Peru

Vaccination against SARS-CoV-2 in Haemodialysis Patients: Spike’s Ab Response and the Influence of BMI and Age

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