Vacuum/Compression Valving (VCV) Using Parrafin-Wax on a Centrifugal Microfluidic CD Platform

Al-Faqheri, Wisam; Ibrahim, Fatimah; Thio, Tzer Hwai Gilbert; Jacob, Mohan V.; Joseph, Karunan; Arof, Hamzah; Madou, Marc

doi:10.1371/journal.pone.0058523

Cited by 61 publications

(53 citation statements)

References 24 publications

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“…by direct contact between the paraffin and a working fluid (Liu et al 2004a(Liu et al , 2004bPal et al 2004;Oh et al 2005;Yousef et al 2005;Park et al 2007;Bodén et al 2008b;Abi-Samra et al 2011;Baek et al 2013). Al-Faqheri et al (2013) used air as a force transmission agent, and used the paraffin to valve venting holes.…”

Section: Actuator Principle and Designmentioning

confidence: 99%

“…However, as previously mentioned, paraffin has also been used as solid plugs that can move freely within microfluidic channels when melted, and then either be flushed out or latched at new positions when solidified. Klintberg 2002aKlintberg , 2003bLiu 2004aLiu , 2004bBodén 2005Bodén , 2006bBodén , 2008bPark 2007;Yang 2007Yang , 2009Yoo 2007;Lehto 2008aLehto , 2008bSant 2010;Feng 2011;Boustheen 2011;AbiSamra 2011;Al-Faqheri 2013;Baek 2013Metal Kobayashi 2004Bodén 2008;Goldschmidtboing 2008;Ogden , 2011Svensson 2010;Sharma 2011b; …”

Section: Actuator Principle and Designmentioning

confidence: 99%

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Review on miniaturized paraffin phase change actuators, valves, and pumps

Ogden

Klintberg

Thornell

et al. 2013

Microfluid Nanofluid

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During the last fifteen years, miniaturised paraffin actuation has evolved through the need of a simple actuation principle, still able to deliver large strokes and high actuation forces at small scales. This is achieved by the large and rather incompressible volume expansion associated with the solid-to-liquid phase transition of paraffin. The common approach has been to encapsulate the paraffin by a stiff surrounding that directs the volume expansion towards a flexible membrane, which deflects in a directed stroke. However, a number of alternative methods have also been used in the literature. The most common applications to this date have been switches, positioning actuators, and microfluidic valves and pumps. This review will treat the historical background, as well as the fundamentals in paraffin actuation, including material properties of paraffin. Besides reviewing the three major groups of paraffin actuator applications; actuators, valves, and pumps, the modelling done on paraffin actuation will be explored. Furthermore, a section focusing on fabrication of paraffin microactuators is also included. The review ends with conclusions and outlook of the field, identifying unexplored potential of paraffin actuation.The final publication is available at Springer via http://dx

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Section: Actuator Principle and Designmentioning

confidence: 99%

Section: Actuator Principle and Designmentioning

confidence: 99%

Review on miniaturized paraffin phase change actuators, valves, and pumps

Ogden

Klintberg

Thornell

et al. 2013

Microfluid Nanofluid

View full text Add to dashboard Cite

show abstract

“…Paraffin valves were also used by Al-Faqheri et al to achieve vacuum-and compression-controlled valving on a disc. 43 The design (see Fig. 6) consisted of source and destination chambers and corresponding vent holes.…”

Section: Active Valvesmentioning

confidence: 99%

Lab-on-a-CD: A Fully Integrated Molecular Diagnostic System

et al. 2016

Self Cite

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The field of centrifugal microfluidics has experienced tremendous growth during the past 15 years, especially in applications such as lab-on-a-disc (LoD) diagnostics. The strength of LoD systems lies in its potential for development into fully integrated sample-to-answer analysis systems. This review highlights the technologies necessary to develop the next generation of these systems. In addition to outlining valving and other fluid-handling operations, we discuss the recent advances and future outlook in four categories of LoD processes: reagent storage, sample preparation, nucleic acid amplification, and analyte detection strategies.

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“…9 However, the siphon valve is prone to be unavoidable for the extraction of liquid after some operation, e.g., the shake mode mixing. 10 Other available active-pumping [11][12][13][14] and icevalving 15 methods have the drawbacks on raising the complexity of systems.…”

Section: Introductionmentioning

confidence: 99%

Euler force actuation mechanism for siphon valving in compact disk-like microfluidic chips

et al. 2014

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Based on the Euler force induced by the acceleration of compact disk (CD)-like microfluidic chip, this paper presents a novel actuation mechanism for siphon valving. At the preliminary stage of acceleration, the Euler force in the tangential direction of CD-like chip takes the primary place compared with the centrifugal force to function as the actuation of the flow, which fills the siphon and actuates the siphon valving. The Euler force actuation mechanism is demonstrated by the numerical solution of the phase-field based mathematical model for the flow in siphon valve. In addition, experimental validation is implemented in the polymethylmethacrylate-based CD-like microfluidic chip manufactured using CO 2 laser engraving technique. To prove the application of the proposed Euler force actuation mechanism, whole blood separation and plasma extraction has been conducted using the Euler force actuated siphon valving. The newly introduced actuation mechanism overcomes the dependence on hydrophilic capillary filling of siphon by avoiding external manipulation or surface treatments of polymeric material. The sacrifice for highly integrated processing in pneumatic pumping technique is also prevented by excluding the volume-occupied compressed air chamber. V C 2014 AIP Publishing LLC. [http://dx

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Vacuum/Compression Valving (VCV) Using Parrafin-Wax on a Centrifugal Microfluidic CD Platform

Cited by 61 publications

References 24 publications

Review on miniaturized paraffin phase change actuators, valves, and pumps

Review on miniaturized paraffin phase change actuators, valves, and pumps

Lab-on-a-CD: A Fully Integrated Molecular Diagnostic System

Euler force actuation mechanism for siphon valving in compact disk-like microfluidic chips

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