Vagal tone regulation during sustained attention in boys exposed to opiates in utero

Hickey, John E.; Suess, Patricia E.; Newlin, David B.; Spurgeon, Loretta; Porges, Stephen W.

doi:10.1016/0306-4603(94)00044-y

Cited by 50 publications

(42 citation statements)

References 12 publications

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“…For example, articles which examined RSA withdrawal and children’s health outcomes such as obesity (Graziano, Calkins, Keane, & O'Brien, 2011), immune response (Cacioppo, 1994), asthma (Miller, Wood, Lim, Ballow, & Hsu, 2009) or epilepsy (Harnod et al, 2008) were excluded. We also excluded articles examining the link between RSA withdrawal and sleep (El-Sheikh & Buckhalt, 2005), substance exposure (Hickey, Suess, Newlin, Spurgeon, & Porges, 1995; Sheinkopf et al, 2007) or parenting factors (Blandon, Calkins, Keane, & O'Brien, 2010; Calkins & Johnson, 1998; Mills-Koonce et al, 2009; Oosterman & Schuengel, 2007). Articles that solely examined the stability of RSA withdrawal (Bornstein & Suess, 2000; El-Sheikh, 2005), or changes in RSA withdrawal associated with treatment (Beauchaine, Gartner, & Hagen, 2000; Graziano, Bagner, Sheinkopf, Vohr, & Lester, 2012) were also excluded.…”

Section: Methodsmentioning

confidence: 99%

Cardiac vagal control and children's adaptive functioning: A meta-analysis

Graziano¹,

Derefinko²

2013

Biological Psychology

387

422

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Polyvagal theory has influenced research on the role of cardiac vagal control, indexed by respiratory sinus arrhythmia withdrawal (RSA-W) during challenging states, in children’s self-regulation. However, it remains unclear how well RSA-W predicts adaptive functioning (AF) outcomes and whether certain caveats of measuring RSA (e.g., respiration) significantly impact these associations. A meta-analysis of 44 studies (n = 4,996 children) revealed small effect sizes such that greater levels of RSA-W were related to fewer externalizing, internalizing, and cognitive/academic problems. In contrast, RSA-W was differentially related to children’s social problems according to sample type (community vs. clinical/at-risk). The relations between RSA-W and children’s AF outcomes were stronger among studies that co-varied baseline RSA and in Caucasian children (no effect was found for respiration). Children from clinical/at-risk samples displayed lower levels of baseline RSA and RSA-W compared to children from community samples. Theoretical/practical implications for the study of cardiac vagal control are discussed.

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Section: Methodsmentioning

confidence: 99%

Cardiac vagal control and children's adaptive functioning: A meta-analysis

Graziano¹,

Derefinko²

2013

Biological Psychology

387

422

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“…77 Heart rate variability (vagal tone) was measured during an attention task. When distracters were added to the attention task, opiate-exposed boys failed to suppress vagal tone compared to both control groups.…”

Section: Prenatal Exposure To Opiatesmentioning

confidence: 99%

Children of Addicted Women

Lester

LaGasse

2010

Journal of Addictive Diseases

118

106

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The purpose of this article was to review follow up studies of children with prenatal drug exposure from preschool through adolescence. Specifically, the authors focus on the effects of prenatal exposure to cocaine, methamphetamine, and opiates on behavior and development. The largest number of studies have examined cocaine-exposed children. The authors identified 42 studies that suggest that there are unique effects of prenatal cocaine exposure on 4- to 13-year-old children, particularly in the areas of behavior problems, attention, language, and cognition. In addition, studies make reasonable attempts to control for possible confounding factors. Systematic research on the long-term effects of prenatal methamphetamine exposure is just beginning but seems to be showing similar effects to that of cocaine. The literature on the on the long-term effects of children with prenatal opiate exposure is more substantial than the methamphetamine literature but it is still relatively sparse and surprising in that there is little recent work. Thus, there are no studies on the current concerns with opiates used for prescription mediation. There is a growing literature using neuroimaging techniques to study the effects of prenatal drug exposure that holds promise for understanding brain/behavior relationships. In addition to pharmacological and teratogenic effects, drugs can also be viewed from a prenatal stressor model. The author discuss this “fetal origins” approach that involves fetal programming and the neuroendocrine system and the potential implications for adolescent brain and behavioral development.

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“…Some clinical studies have also suggested an increased prevalence of heart defects, autonomic dysregulation (Paul et al, 2014), nystagmus (Gupta et al, 2012), and strabismus (Gill et al, 2003) in children exposed prenatally to opiates. At the pre-and elementary school ages, these children show motor and cognitive impairments (Bunikowski et al, 1998;Guo et al, 1994;Hunt et al, 2008), inattention (Hickey et al, 1995;Ornoy et al, 1996), hyperactivity (Ornoy et al, 1996), and an increase in ADHD when exposed prenatally to heroin (Ornoy et al, 2001). The damage of prenatal opiate exposure is debilitating and long lasting, and physicians must continue to track cohorts of exposed children to further understand the impact into adulthood.…”

Section: Opioidsmentioning

confidence: 99%

Developmental Consequences of Fetal Exposure to Drugs: What We Know and What We Still Must Learn

Ross

Graham

Money

et al. 2014

Neuropsychopharmacol

341

241

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Most drugs of abuse easily cross the placenta and can affect fetal brain development. In utero exposures to drugs thus can have long-lasting implications for brain structure and function. These effects on the developing nervous system, before homeostatic regulatory mechanisms are properly calibrated, often differ from their effects on mature systems. In this review, we describe current knowledge on how alcohol, nicotine, cocaine, amphetamine, Ecstasy, and opiates (among other drugs) produce alterations in neurodevelopmental trajectory. We focus both on animal models and available clinical and imaging data from cross-sectional and longitudinal human studies. Early studies of fetal exposures focused on classic teratological methods that are insufficient for revealing more subtle effects that are nevertheless very behaviorally relevant. Modern mechanistic approaches have informed us greatly as to how to potentially ameliorate the induced deficits in brain formation and function, but conclude that better delineation of sensitive periods, dose-response relationships, and long-term longitudinal studies assessing future risk of offspring to exhibit learning disabilities, mental health disorders, and limited neural adaptations are crucial to limit the societal impact of these exposures.

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Vagal tone regulation during sustained attention in boys exposed to opiates in utero

Cited by 50 publications

References 12 publications

Cardiac vagal control and children's adaptive functioning: A meta-analysis

Cardiac vagal control and children's adaptive functioning: A meta-analysis

Children of Addicted Women

Developmental Consequences of Fetal Exposure to Drugs: What We Know and What We Still Must Learn

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