Vaginosis-associated bacteria and its association with HPV infection

Cervical Squamous Intraepithelial Lesions Are Associated with Differences in the Vaginal Microbiota of Mexican Women

“…However, these findings are not uniform across studied populations. Despite the fact that Latin American countries have a high prevalence of HPV and cervical cancer is one of the main causes of death in Latin American women ( 3 , 23 – 25 ), including Mexico ( 7 , 9 ), most of the studies have been conducted in industrialized countries ( 26 ). Likewise, the projected demographic changes in Latin America imply that the current burden of new cervical cancer cases will increase in the next 20 years ( 2 , 27 ).…”

“…Likewise, the projected demographic changes in Latin America imply that the current burden of new cervical cancer cases will increase in the next 20 years ( 2 , 27 ). The evidence observed so far suggests that the ethnic and sociodemographic factors that influence differences in vaginal microbiota composition may also underlie dysbiotic patterns linked to HPV infection and cervical cancer across different Latin American women populations ( 3 , 7 , 9 , 23 – 25 ). Therefore, there is a growing need for more evidence on the association between vaginal microbiota patterns and HPV infection in Latin America and its relationship with the progression of SIL to cervical cancer.…”

Cervical Squamous Intraepithelial Lesions are Associated with Changes in the Vaginal Microbiota of Mexican Women

“…However, these findings are not uniform across studied populations, because, despite the fact that Latin American countries have a high prevalence of HPV and cervical cancer are one of the main causes of death in women in these areas (3, 23–25), including Mexico (7, 9), most of the studies have been conducted in developed countries (26). Likewise, the projected demographic changes in Latin America imply that the current burden of new cervical cancer cases will increase in the next 20 years (2, 27).…”

“…Some of these changes are responsible for increasing the levels of mucin-degrading enzymes, which may play a role in the degradation of the mucous layer that covers the vaginal and cervical epithelium and endocervical mucus (20,21). There is evidence of HPV evasion or infection mechanisms that support that microorganisms such as Sneathia, Anaerococcus, Fusobacterium and Gardnerella are implicated with higher frequency and severity of disease, potentially resulting in pre-cancerous and cancerous cervical lesions (22) However, these findings are not uniform across studied populations, because, despite the fact that Latin American countries have a high prevalence of HPV and cervical cancer are one of the main causes of death in women in these areas (3,(23)(24)(25), including Mexico (7,9), most of the studies have been conducted in developed countries (26). Likewise, the projected demographic changes in Latin America imply that the current burden of new cervical cancer cases will increase in the next 20 years (2,27).…”

“…Likewise, the projected demographic changes in Latin America imply that the current burden of new cervical cancer cases will increase in the next 20 years (2, 27). The evidence observed so far suggests that the ethnic and sociodemographic factors that influence difference in vaginal microbiome composition may also underlie dysbiotic patterns linked to HPV infection and cervical cancer across different Latin America women populations (3,7,9, 23–25). Therefore, there is a growing need for more evidence in Latin America to demonstrate the association between vaginal microbiota patterns and HPV infection and its relationship with the progression of SIL to cervical cancer.…”