Vagus nerve stimulation as a promising adjunctive treatment for ischemic stroke

Ma, Jue; Qiao, Peifeng; Li, Qin; Wang, Yangyang; Zhang, Lan; Yan, Liang; Cai, Zhiyou

doi:10.1016/j.neuint.2019.104539

Cited by 36 publications

(19 citation statements)

References 158 publications

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“…Ischemic stroke accounts for 80% of all strokes, and the key to successful treatment is timely thrombolysis to prevent irreversible, permanent damage (Hsu et al, 2017). Only 10% or fewer patients can be treated within the optimal time window, and contraindications to thrombolytic therapy can exist that are not conducive to its clinical application (Ma et al, 2019). Neuroprotection is an important auxiliary target of thrombolytic therapy during the ischemic stage, especially for the neuroprotection of the penumbra region (Moretti et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

The mechanisms through which auricular vagus nerve stimulation protects against cerebral ischemia/reperfusion injury

et al. 2022

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Section: Discussionmentioning

confidence: 99%

The mechanisms through which auricular vagus nerve stimulation protects against cerebral ischemia/reperfusion injury

et al. 2022

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“…There is emerging clinical evidence for efficacy in other CNS disorders including AD 53 and stroke. 104 VNS has proven to be very efficacious in reducing seizure frequency in treatment-refractory epilepsy, 105 though its mechanism of action is not understood. It was first used in epilepsy over 30 years ago, long predating characterization of the CAP, and was thought to directly inhibit the electrical activity of partial seizures.…”

Section: The Inflammatory Reflex In Diseasementioning

confidence: 99%

Manipulation of the inflammatory reflex as a therapeutic strategy

Kelly

Breathnach²,

Tracey³

et al. 2022

Cell Reports Medicine

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“…Mice in group A and B were stimulated with 500µs width 2mA electric pulses for 10min at 5Hz every day for 10 mins, from 6h after surgery and each day for 7 days, 7 times in total [12]. Mice in group C were operated the same way as mice in group B, but no electrical stimulation was applied.…”

Section: Vagus Nerve Electrode Implantationmentioning

confidence: 99%

Effect and mechanism of electrical vagus nerve stimulation on ischemic stroke injury in mice by promoting vascular endothelial regeneration

Xiong

Sheng

et al. 2022

Preprint

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Objective: In this study vagus nerve stimulation (VNS) was used in mouse ischemic stroke model to observe its effects on the proliferation of vascular endothelial cells and gliogenesis, and to explore the potential protective mechanism of VNS on ischemic stroke angiogenesis. Methods: 80 male C57BL/6J mice were randomly divided into four groups: A: Sham+VNS group; B: pMCAO+VNS group; C: pMCAO +VNI group D: Sham group. The behavioral changes of mice were monitored after operation. Laser speckle Doppler imager was used to detect the cerebral blood flow and blood vessel density of mice at 6 hours, 3 days, 7 days and 14 days after operation. Evans Blue method was used to measure blood-brain barrier integrity, the ratio of dry and wet weight of brain tissue was measured to measure the degree of edema in the brain tissue of mice in each group, CD31/Ki67, GFAP/Ki67, and Ibal/Ki67 were identified by immunofluorescence method to label new vascular endothelial cells and new glial cells, The expressions of angiogenic factors such as endothelial nitric oxide synthase (eNOS), brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) were detected by Elisa Kits.Results: 1. VNS treatment can effectively improve neurological deficit scores of the stroke mice after VNS treatment at 7 days, 14 days and 21 days (P<0.05); 2.Laser speckle Doppler imager showed that vascular density in pMCAO+VNS group was more obvious increased than in pMCAO+VNI group at every moment (P<0.05). 3.T Evans Blue method suggested that VNS could reduce the degree of damage to the blood-brain barrier after ischemic stroke (P<0.05) and also effectively reduce the degree of brain edema after pMCAO (P<0.05). 4. CD31/Ki67, GFAP/Ki67 and Ibal/Ki67 co-localize, suggesting that VNS can induce new blood vessels in the ischemic penumbra 5. VNS induce the up-regulation of BDNF, eNOS and VEGF protein expression in the ischemic penumbra of brain tissue after pMCAO (P<0.05).Conclusion: VNS can improve the nerve injury of ischemic stroke by regulating vascular endothelial cell regeneration and glial cell remodeling, and provide guidance for further exploration of stroke neuroprotection.

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Vagus nerve stimulation as a promising adjunctive treatment for ischemic stroke

Cited by 36 publications

References 158 publications

The mechanisms through which auricular vagus nerve stimulation protects against cerebral ischemia/reperfusion injury

The mechanisms through which auricular vagus nerve stimulation protects against cerebral ischemia/reperfusion injury

Manipulation of the inflammatory reflex as a therapeutic strategy

Effect and mechanism of electrical vagus nerve stimulation on ischemic stroke injury in mice by promoting vascular endothelial regeneration

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