Vagus nerve stimulation therapy summary

Schachter, Steven C.

doi:10.1212/wnl.59.6_suppl_4.s15

Cited by 161 publications

(104 citation statements)

References 51 publications

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“…Distributing stimulation across multiple electrodes might be attractive for several reasons. First, the amplitude of pulses delivered to each electrode could be much lower, reducing commensurately the risk of side effects (Wheless, 2001;Schachter, 2002), tissue damage (Shepherd et al, 1991;Tehovnik, 1996), or electrode damage. Second, the system would be more fault tolerant (Davis, 2000), because losing one or two electrodes from a large ensemble would hardly compromise efficacy.…”

Section: Discussionmentioning

confidence: 99%

Controlling Bursting in Cortical Cultures with Closed-Loop Multi-Electrode Stimulation

Wagenaar¹,

Madhavan²,

Pine³

et al. 2005

J. Neurosci.

400

349

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One of the major modes of activity of high-density cultures of dissociated neurons is globally synchronized bursting. Unlike in vivo, neuronal ensembles in culture maintain activity patterns dominated by global bursts for the lifetime of the culture (up to 2 years). We hypothesize that persistence of bursting is caused by a lack of input from other brain areas. To study this hypothesis, we grew small but dense monolayer cultures of cortical neurons and glia from rat embryos on multi-electrode arrays and used electrical stimulation to substitute for afferents. We quantified the burstiness of the firing of the cultures in spontaneous activity and during several stimulation protocols. Although slow stimulation through individual electrodes increased burstiness as a result of burst entrainment, rapid stimulation reduced burstiness. Distributing stimuli across several electrodes, as well as continuously fine-tuning stimulus strength with closed-loop feedback, greatly enhanced burst control. We conclude that externally applied electrical stimulation can substitute for natural inputs to cortical neuronal ensembles in transforming burst-dominated activity to dispersed spiking, more reminiscent of the awake cortex in vivo. This nonpharmacological method of controlling bursts will be a critical tool for exploring the information processing capacities of neuronal ensembles in vitro and has potential applications for the treatment of epilepsy.

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Section: Discussionmentioning

confidence: 99%

Controlling Bursting in Cortical Cultures with Closed-Loop Multi-Electrode Stimulation

Wagenaar¹,

Madhavan²,

Pine³

et al. 2005

J. Neurosci.

400

349

View full text Add to dashboard Cite

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“…Numerous studies have described its safety and effectiveness 10) . Although our study was characterized by a relatively short follow-up period and a small patient group, 6 patients became seizure-free with medication, and 5 patients showed reduced seizure frequency by more than 50% at last follow-up.…”

Section: Discussionmentioning

confidence: 99%

“…Many authors have described the safety and effectiveness of VNS. Its benefits include reduction in the severity of seizures 9,10) . Several studies have shown that the effectiveness of VNS increases with time after the procedure 7) .…”

Section: Introductionmentioning

confidence: 99%

Effect of Vagus Nerve Stimulation in Post-Traumatic Epilepsy and Failed Epilepsy Surgery : Preliminary Report

Lee

Koh

et al. 2008

J Korean Neurosurg Soc

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“…Related side effects can include voice alteration, hoarseness, throat or neck pain, headache, cough, dyspnea, vocal cord paralysis, and aspiration. 11,44,61,62 The procedure is technically relatively simple, but it is very important to talk with patients before surgery about their expectations regarding outcome. To our knowledge, no results have been reported for vagus nerve stimulation applied specifically to the treatment of seizures associated with cerebrovascular malformations.…”

Section: Neuroaugmentative Surgerymentioning

confidence: 99%

Cerebral cavernous malformations and epilepsy

Awad¹,

Jabbour²

2006

FOC

151

117

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✓Seizures and epilepsy are frequent clinical manifestations of cerebral cavernous malformations (CCMs) and represent the most common symptomatic presentation of supratentorial lesions. Clinicians often diagnose CCMs in patients after a first seizure, or in some cases after obtaining neuroimaging studies in patients suffering from chronic epilepsy previously thought to be idiopathic. In some cases, the lesion is clinically significant solely because of its epileptogenicity, but in others there may be concern about potential hemorrhage or focal neurological deficits from a similar lesion. The authors present current pathophysiological concepts related to epilepsy associated with CCMs. They discuss the spectrum of seizure disorders associated with these lesions and review the natural history, prognosis, and options for therapeutic intervention.

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Vagus nerve stimulation therapy summary

Cited by 161 publications

References 51 publications

Controlling Bursting in Cortical Cultures with Closed-Loop Multi-Electrode Stimulation

Controlling Bursting in Cortical Cultures with Closed-Loop Multi-Electrode Stimulation

Effect of Vagus Nerve Stimulation in Post-Traumatic Epilepsy and Failed Epilepsy Surgery : Preliminary Report

Cerebral cavernous malformations and epilepsy

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