CeIrIn 5 have been attracted by the superconductivity, field-induced transition at H * ∼ 30 T, and metamagnetic behavior in magnetization at H ′ m ∼ 42 T. We measured the electrical resistivity, magnetic susceptibility, and high-field magnetization of single crystals of La x Ce 1−x IrIn 5 and CeIr(In 1−x X x) 5 (X=Cd, Sn) in order to investigate the substitution effect on the metamagnetic behavior. Our highfield magnetization measurement revealed that H ′ m is not changed in La x Ce 1−x IrIn 5 and shifted to higher fields as function of x in CeIr(In 1−x Cd x) 5. On the other hand, in CeIr(In 1−x Sn x) 5 for x = 0.025, the metamagnetic behavior is not detected up to 55 T. The mechanism of metamagnetic behavior is discussed by considering a substitution effect on the 4 f electron state in Ce.