Valeur predictive du PSA dans le diagnostic du cancer de la prostate chez les sujets Beninois

Loko, F; Hodonou, R.; Akpaka, R; Hounnasso, Prince Pascal; Adisso, S; C, Akpo

doi:10.4314/ijbcs.v5i2.72096

Cited by 4 publications

(2 citation statements)

References 19 publications

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“…The mean age of our patients was 72,43 years with extreme values ranging from 56 to 86 years old. These epidemiological findings were similarly reported by various other authors [4][5][6].…”

Section: Discussionsupporting

confidence: 91%

Evaluation of the effectiveness of the prostate biopsy at the Saint Jean De Dieu Hospital of Tanguieta

KF,

et al. 2023

Int J Res Oncol

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Introduction: Prostate cancer is the most common and the second leading cause of cancer death in men in most developed countries. Prostate biopsy remains the gold standard to confirm its diagnosis. Material and Method: This is a prospective study during 6 months, starting from 1st of February to 31st of July 2022. It included all patients who underwent a prostate biopsy that was carried out either following a high tPSA or due to an abnormal digital rectal examination. Results: We performed digitally guided biopsies in 32 patients from whom, average age was 72.43 years and elevation of total PSA was the main reason (71.88%) behind biopsies. The mean total PSA level was 45.69 ng/ml. The tissues removed were essentially prostate tissues, malignant in 28.12% of cases with adenocarcinoma as the only histological type. Conclusion: Prostate biopsy remains the gold standard for the diagnosis of prostate cancer. When indicated in front of an abnormal digital rectal examination, the probabilities of positivity of the samples are high even in the case of digitally guided biopsies in an under-equipped environment.

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Section: Discussionsupporting

confidence: 91%

Evaluation of the effectiveness of the prostate biopsy at the Saint Jean De Dieu Hospital of Tanguieta

KF,

et al. 2023

Int J Res Oncol

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“…The digital rectal examination (DRE) combined with the total PSA test is essential in the diagnostic process. The positive predictive value of DRE is around 5% -30% [6]. With a cut-off value of 4 ng/ml, the sensitivity of total PSA to detect cancer is approximately 70%, and its specificity is 90% [7].…”

Section: Discussionmentioning

confidence: 99%

Conformational Radiotherapy of Prostatic Adenocarcinoma at the Dalal Jamm Hospital, Senegal—(Retrospective Analysis of a Series of 62 Cases)

Bâ¹,

Diallo²,

Sarr³

et al. 2020

JCT

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Aim: We endeavored to describe the epidemiological profile of prostatic cancer, and to evaluate its diagnostic and therapeutic aspects. Method: We conducted a descriptive retrospective study on the conformational radiotherapy of prostatic adenocarcinoma at the Dalal Jamm University Hospital, Senegal from June 2018 to December 2019. We included 62 consecutive patients. The average age of the patients was 68.9 years. The average consultation time was 7.6 months. Results: Symptom manifestation and high PSA triggered the diagnosis of cancer in 74.2% and 25.8% of patients, respectively. Symptoms: pollakiuria (72.3%), bone pain (8%) and erectile dysfunction (4.8%). The digital rectal examination: normal (33.8%), nodular (30.6%), induration (24.1%), and shielding (11.3%). The mean PSA level was 90.6 ng/ml. Histology: adenocarcinoma was the most common (98.6%). The Gleason score: <7 (45.1%), =7 (35.5%), and >7 (19.4%). The majority of patients were in the high-risk group (70.9%) and 7 patients (11.2%) were metastatic at diagnosis. Therapy: first radical prostatectomy (20.9%), first-line curative radiotherapy (67.8%), adjuvant (21%) and palliative radiotherapy in 7 patients (11.2%): patients having received palliative radiotherapy had an estimated decline in symptoms of 80%. Hormone therapy was performed in 88.8% of patients, with average duration of 12.5 months. After a mean follow-up of 15 months, 59 patients were alive, including 45 cases (81.8%) in complete remission; 3 patients with metastasis at the first visit (having received palliative radiotherapy) died. Conclusion: The collected data show a profile of prostate cancer that is specific to the sub-Saharan context in which the discovery is still late. Also in comparison to developed countries, the therapeutic means necessary to fight against this cancer are limited, even though How to cite this paper:

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Intraductal Prostatic Carcinoma: Epidemiological and Anatomopathological Aspects in Dakar

Thiam,

Senghor,

Sow

et al. 2024

OJPathology

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Introduction: Intraductal carcinoma is often associated with high-grade, high-stage adenocarcinoma. Its frequency is variable and it is considered a poor prognostic factor. In our context, when prostatic carcinoma is diagnosed, pathologists do not always report the presence of this anatomopathological entity. We therefore conducted a study to determine the epidemiological and anatomopathological profile of patients with this lesion in Dakar. Materials and Methods: This is a retrospective descriptive study covering a 1-year period from January to December 2022. It focused on cases of intraductal carcinoma diagnosed among prostatic carcinomas collected in the anatomopathology laboratories of Hôpital Général Idrissa Pouye (HOGIP) and Hôpital Militaire de Ouakam (HMO). It was based on archives of anatomopathological reports, blocks and slides. A total of 200 cases of prostatic carcinoma were collated and reviewed to identify those presenting with intraductal carcinoma according to the diagnostic criteria of Guo and Epstein. Results: 87 cases of intraductal carcinoma were found, representing 43.5% of prostatic carcinomas. The mean age was 71 years. Patients in their seventh decade were the most represented, i.e. 42.5%. The majority of samples examined were biopsies (72.4%). The mean PSA level was 965.91 ng/ml, with extremes ranging from 0.03 to 10,000 ng/ml. Histologically, 96.5% of cases (N = 84) were invasive prostatic carcinoma. Gleason score 8 (4 + 4) was the most common, accounting for 42.53% (N = 37). On average, the study found four (04) foci of intraductal carcinoma per specimen, with extremes ranging from 1 to 30. Dense cribriform architecture accounted for 78.16%, loose cribriform for 11.5%, solid for 8.

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Valeur predictive du PSA dans le diagnostic du cancer de la prostate chez les sujets Beninois

Cited by 4 publications

References 19 publications

Evaluation of the effectiveness of the prostate biopsy at the Saint Jean De Dieu Hospital of Tanguieta

Evaluation of the effectiveness of the prostate biopsy at the Saint Jean De Dieu Hospital of Tanguieta

Conformational Radiotherapy of Prostatic Adenocarcinoma at the Dalal Jamm Hospital, Senegal—(Retrospective Analysis of a Series of 62 Cases)

Intraductal Prostatic Carcinoma: Epidemiological and Anatomopathological Aspects in Dakar

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