Valgus knee bracing may have no long-term effect on pain improvement and functional activity in patients with knee osteoarthritis: a meta-analysis of randomized trials

Fan, Yinuo; Li, Zhongfeng; Zhang, Haitao; Hong, Guoju; Wu, Zhongshu; Liu, Weifeng; Chen, Lixin; Wu, Yiping; Wei, Qiushi; He, Wei; Chen, Zhenqiu

doi:10.1186/s13018-020-01917-x

Cited by 8 publications

(7 citation statements)

References 43 publications

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“…Although valgus-inducing knee braces seem to reduce pain in the short term in patients with osteoarthritis [28], there are still few data on their effectiveness in the context of haemophilic arthropathy. Insoles seem to S2 Blood Coagulation and Fibrinolysis 2023, Vol 34 (Suppl 1) improve joint pain and joint function in patients with haemophilic arthropathy of the ankle with hindfoot malalignment [29].…”

Section: Orthotic Devicesmentioning

confidence: 99%

Chronic pain in haemophilia: assessment and analgesic treatment

Corte‐Rodríguez¹,

Rodríguez-Merchán²

2023

Blood Coagulation &Amp; Fibrinolysis

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People with haemophilia tend to experience pain from an early age because of venipuncture and hemarthrosis. If pain is not properly managed, it can become chronic and bedevil patients throughout their lives. Therapies are currently available that have been shown to effectively treat the different types of pain and their causes. Patients with haemophilia tend to experience either nociceptive or mixed pain. Identification of the cause of pain by means of imaging techniques, and understanding the characteristics, location and intensity of the pain, are essential for a more targeted therapeutic approach. Current data reveal that the most effective measures are administration of haematological and analgesic medication, intraarticular injections, and physical exercise. However, multimodal strategies such as lifestyle changes, physical modalities, psychological support and orthopaedic surgery can also prove of use. This article will look at the most effective analgesic measures used as a part of conservative clinical treatment. Collaborative studies are needed to better understand the nature of pain in the context of haemophilia.

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Section: Orthotic Devicesmentioning

confidence: 99%

Chronic pain in haemophilia: assessment and analgesic treatment

Corte‐Rodríguez¹,

Rodríguez-Merchán²

2023

Blood Coagulation &Amp; Fibrinolysis

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“…[5][6][7] It is pertinent to note that OA is more prevalent in the elderly population, and its prevalence increases with age. 8 The condition causes significant economic and property losses globally, 6,7 particularly for individuals over 65 years old. 9,10 OA results from a combination of individual and joint factors, including age, gender, obesity, genetics, diet, injury, joint malalignment, and abnormal joint loading.…”

Section: Introductionmentioning

confidence: 99%

Pyroptosis in Osteoarthritis: Molecular Mechanisms and Therapeutic Implications

Chen,

Zeng,

Wei

et al. 2024

JIR

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Osteoarthritis (OA) is a chronic disease that causes pain and functional impairment by affecting joint tissue. Its global impact is noteworthy, causing significant economic losses and property damage. Despite extensive research, the underlying pathogenesis of OA remain an area of ongoing investigation. It has recently been discovered that the OA progression is significantly influenced by pyroptosis. Pyroptosis is a complex process that involves three pathways culminating in the assembly of Gasdermin-D (GSDMD)-N-terminal (GSDMD-NT) into pores through aggregation on the plasma membrane. The aggregation of GSDMD-NT proteins stimulates the release of inflammatory mediators, such as Interleukin-1β (IL-1β), Interleukin-18 (IL-18), and Matrix Metallopeptidase 13 (MMP13), ultimately leading to cellular lysis. The pyroptosis process in specific cells, including synovial macrophages, fibroblast-like synoviocytes (FLS), chondrocytes, and subchondral osteoblasts, contributs factor to the development of OA. Currently, the specific cells that undergo pyroptosis first are not yet fully understood, and it remains unknown whether pyroptosis in one cell can trigger the same process in other cells. Therefore, targeting pyroptosis could potentially offer a novel treatment approach for OA patients. We present a comprehensive analysis of the molecular mechanisms and key features of pyroptosis. We also outline the current research progress on various aspects, including synovial tissue, articular cartilage, extracellular matrix (ECM), and subchondral bone, with a focus on pyroptosis. The aim is to provide theoretical references for the effective management of OA.

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“…Different types of knee orthoses (ranging from rigid braces to soft sleeves) exist [ 14 ]. Rigid braces, such as an unloader or a valgus brace, are designed as rigid shells with a hinge joint and straps to correct the lower limb force lines of the varus leg alignment to biomechanically unload the knee joint during motion [ 15 ]. The biomechanical results are encouraging, and meta-analyses on valgus bracing suggest improvements in pain [ 16 , 17 ], but current evidence is limited [ 1 , 15 ], and a lack of comfort can lead to a limited compliance [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of a Semi-Rigid Knee Orthotic Intervention on Pain, Physical Activity, and Functional Capacity in Patients with Medial Knee Osteoarthritis

Stetter,

Fiedler,

Arndt

et al. 2024

JCM

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Background: The effectiveness of knee orthoses as part of conservative treatment for patients with medial knee osteoarthritis has not been fully explored. The purpose of this study was to evaluate the effects of a novel semi-rigid knee orthosis on pain, physical activity, and functional capacity. Methods: Pain levels, physical activity, and functional capacity were assessed in 24 participants experiencing symptomatic medial knee osteoarthritis one week before (i.e., pretest) initiating a six-week orthosis intervention and again during the final week of the intervention (i.e., post-test). Results: Night pain, pain during walking, pain during stair climbing, and pain during sitting consistently decreased by 41% to 48% while wearing the knee orthosis. Device-based measured physical activity showed a 20.2-min increase in vigorous physical activity during the post-test, while light and moderate physical activity did not show significant changes. After six weeks of orthosis application, there was a 5% increased distance for the six-minute walk test, and participants reported fewer limitations both in everyday and athletic activities, as well as an enhanced quality of life. Conclusions: These findings highlight the potential effectiveness of a semi-rigid knee orthosis to enhancing functional capacity and quality of life. More extensive and longer clinical trials are needed to improve confidence in these findings and understand their impact on disease progression.

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Valgus knee bracing may have no long-term effect on pain improvement and functional activity in patients with knee osteoarthritis: a meta-analysis of randomized trials

Cited by 8 publications

References 43 publications

Chronic pain in haemophilia: assessment and analgesic treatment

Chronic pain in haemophilia: assessment and analgesic treatment

Pyroptosis in Osteoarthritis: Molecular Mechanisms and Therapeutic Implications

Impact of a Semi-Rigid Knee Orthotic Intervention on Pain, Physical Activity, and Functional Capacity in Patients with Medial Knee Osteoarthritis

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