Validated liquid chromatographic method and analysis of content of tilianin on several extracts obtained from Agastache mexicana and its correlation with vasorelaxant effect

Hernández-Abreu, Oswaldo; Durán-Gómez, Liliana; Best-Brown, Roberto; Villalobos‐Molina, Rafael; Rivera‐Leyva, Julio César; Estrada‐Soto, Samuel

doi:10.1016/j.jep.2011.09.041

Cited by 22 publications

(9 citation statements)

References 18 publications

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“…Various extraction techniques were applied: maceration at ambient or elevated temperature, reflux extraction, infusions and decoctions in hot water. The extracts were usually dried under reduced pressure or by lyophilization (Itokawa et al 1981; Ganeva et al 1994; Lee et al 1995, 2002, 2007, 2008; Kim et al 1999; Molina-Hernandez et al 2000; Suvitayavat et al 2004; Vera-Montenegro et al 2008; Xu et al 2008; Hernandez-Abreu et al 2009, 2011, 2013; Gonzalez-Trujano et al 2012). …”

Section: Phytochemistrymentioning

confidence: 99%

“…This compound appears to be more representative for A. mexicana than for A. rugosa . The content of tilianin in A. mexicana aerial parts measured in various methanol extracts was over 8 mg/g of dried herb (Hernandez-Abreu et al 2011). A. rugosa contains much lower amounts of tilianin, reaching 6.33 μg/g d.w. in flowers and even less in other organs (2.18 μg/g in leaves, 0.49 μg/g in stems, and 0.14 μg/g in roots) (Tuan et al 2012).…”

Section: Phytochemistrymentioning

confidence: 99%

“…The antihypertensive properties of A. mexicana used in folk herbal medicine in Mexico are attributed to tilianin content (Hernandez-Abreu et al 2009). In a comparative study of various solvent extracts prepared from herbs dried at different temperatures, vasorelaxant ex vivo activity correlated with the amount of tilianin (Hernandez-Abreu et al 2011). However, the tilianin potency in relaxing rat aortic contractions was significantly weaker than the reference drug carbachol (EC 50 104 µg/ml and 0.075 µg/ml, respectively).…”

Section: Bioactivity Of Individual Species As Medicinal Plantsmentioning

confidence: 99%

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Phytochemistry and bioactivity of aromatic and medicinal plants from the genus Agastache (Lamiaceae)

2014

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Agastache is a small genus of Lamiaceae, comprising 22 species of perennial aromatic medicinal herbs. In this article, we review recent advances in phytochemical, pharmacological, biotechnological and molecular research on Agastache. The phytochemical profile of all Agastache species studied to date is generally similar, consisted of two main metabolic classes—phenylpropanoids and terpenoids. In the relatively variable essential oils, most populations of different Agastache species contain over 50 % of a phenylallyl compound—estragole. Also, other volatile compounds (methyleugenol, pulegone, menthone, isomenthone and spathulenol) were reported in various proportions. Major non-volatile metabolites belong to phenolic compounds, such as caffeic acid derivatives, especially rosmarinic acid as well as several flavones and flavone glycosides like acacetin, tilianin, agastachoside, and a rare dimeric malonyl flavone (agastachin). Two unique lignans—agastenol and agastinol—were also isolated. Terpenoids include triterpenoids of oleanane-type (maslinic acid, oleanolic acid and β-amyrin), ursane-type (ursolic acid, corosolic acid and α-amyrin), and typical plant sterols, as well as abietane-type oxidized diterpenes (e.g., agastaquinone, agastol, and others). The bioactivity of various extracts or individual compounds in vitro and in vivo include antimicrobial, antiviral and anti-mutagenic activity, cytotoxic activity to cancer cell lines, and anti-nociceptive, anti-inflammatory, anti-atherogenic, antioxidant as well as biocidal activity to several foodstuff pests. Biotechnological and molecular studies have focused on in vitro propagation and enhancing the biosynthesis of bioactive metabolites in cell or organ cultures, as well as on the expression of genes involved in phenolic biosynthesis.

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Section: Phytochemistrymentioning

confidence: 99%

Section: Phytochemistrymentioning

confidence: 99%

Section: Bioactivity Of Individual Species As Medicinal Plantsmentioning

confidence: 99%

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Phytochemistry and bioactivity of aromatic and medicinal plants from the genus Agastache (Lamiaceae)

2014

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“…Trujano et al, 2012;Ibarra-Alvarado et al, 2010;Argueta et al, 1994). Studies have reported the isolation of chemical compounds from this plant including diosmetin, gardenin A, acacetin, ursolic acid, and tilianin (Estrada-Reyes et al, 2014;Verano et al, 2013;Hernandez-Abreu et al, 2011), and the main constituents of its essential oil were are pulegone (75%), menthone (14%), and limonene (3%) (Svoboda et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

Antifungal activity of essential oils extracted from Agastache mexicana ssp. xolocotziana and Porophyllum linaria against post-harvest pathogens

Juárez

Hernández

Bach

et al. 2015

Industrial Crops and Products

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“…Además, se registra un trabajo anatómico y etnobotánico de especies mexicanas (Santillán-Ramírez et al 2008). También se han realizado algunos estudios para comprender mejor los compuestos que subyacen a las propiedades aromáticas y curativas de sus especies (Hernández-Abreu et al 2011, Sánchez-Recillas et al 2014, FloresFlores et al 2016) y aquellos que podrían ser útiles en la conservación de granos y vegetales en almacenes (Juárez et al 2015). Este género aún no cuenta con un análisis que esclarezca sus relaciones filogenéticas.…”

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Lamiaceae de México

et al. 2017

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ResumenAntecedentes: Lamiaceae es una de las familias con mayor riqueza de especies en México. Sin embargo, aún se carece de un estudio detallado sobre su diversidad en el país y de una revisión taxonómica global y actualizada. Como resultado, el aprovechamiento y conservación de los integrantes de esta familia es limitado. Preguntas: ¿Qué avances se han logrado en el estudio y entendimiento de la riqueza, endemismo y distribución de las Lamiaceae mexicanas? ¿Qué estrategias deben ejecutarse para consolidar el conocimiento de la familia en el país? Taxon: Lamiaceae Sitio de estudio: México Métodos: Se hizo una revisión exhaustiva de las Lamiaceae mexicanas en la literatura, bases de datos y herbarios. Se sintetizó el estado de su conocimiento. Se aplicaron análisis cuantitativos para evaluar su riqueza, endemismo y distribución geográfica. Resultados: México cuenta con 33 géneros y 598 especies, de las cuales el 66.2 % son endémicas. El género más diverso es Salvia, con 306 especies. El estado más diverso es Oaxaca, mientras que Jalisco alberga el mayor número de especies endémicas. Conclusiones: En México, Lamiaceae es la octava familia más diversa y el número de sus especies representa el 5.5 % de la familia a nivel mundial, por lo que el país puede considerarse uno de los centros de diversificación más importante. Debido a lo anterior, y al endemismo elevado que presenta, México es crucial para la conservación in situ de la familia. Si bien se ha logrado un avance considerable de su conocimiento y en la actualidad hay un repunte en su estudio, es necesario diversificar los campos de investigación. Palabras clave: distribución geográfica, endemismo, Lamiaceae mexicanas, riqueza florística. AbstractBackground: Lamiaceae is one of the most species-rich families in Mexico. However, a detailed treatment on its diversity and an updated comprehensive taxonomic review for the country are still lacking. As a result, the use and conservation of the members of Lamiaceae is limited. Questions: Which advances have been achieved on the study and understanding of the Mexican Lamiaceae in terms of richness, endemism and distribution? Which strategies should be applied to enhance the knowledge of Lamiaceae in Mexico? Taxon: Lamiaceae Study site: Mexico Methods: A thorough review of Mexican Lamiaceae in the literature, databases and herbaria was conducted. The state of knowledge of the family was summarized. Quantitative analyses were performed to assess its richness, endemism and geographical distribution. Results: Mexico embraces 33 genera and 598 species of Lamiaceae, with an endemism proportion of 66.2 %. The most diverse genus is Salvia, with 306 species. Oaxaca is the state encompassing the highest richness, whereas Jalisco harbors the highest amount of endemic species. Conclusions: In Mexico Lamiaceae is the eighth most species-rich family, with a number of species equivalent to 5.5 % of all Lamiaceae worldwide; hence the country is one of the most relevant diversification centers for the family. The high species richne...

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Validated liquid chromatographic method and analysis of content of tilianin on several extracts obtained from Agastache mexicana and its correlation with vasorelaxant effect

Cited by 22 publications

References 18 publications

Phytochemistry and bioactivity of aromatic and medicinal plants from the genus Agastache (Lamiaceae)

Phytochemistry and bioactivity of aromatic and medicinal plants from the genus Agastache (Lamiaceae)

Antifungal activity of essential oils extracted from Agastache mexicana ssp. xolocotziana and Porophyllum linaria against post-harvest pathogens

Lamiaceae de México

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