2016
DOI: 10.1016/j.jchromb.2016.06.011
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Validated methods for determination of neurotransmitters and metabolites in rodent brain tissue and extracellular fluid by reversed phase UHPLC–MS/MS

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Cited by 50 publications
(32 citation statements)
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“…The distribution tendencies of DA, 5-HT and GABA determined in rat brain were similar to those reported in previous studies (Bergh et al, 2016;González et al, 2011;Wojnicz et al, 2016). Levels of the inhibitory amino acid GABA were the most abundant of the three NTs, and were similar among the regions (around 300 μg/g), except in the hypothalamus (520 μg/g).…”
Section: Determination Of Nts In Rat Brain Samplessupporting
confidence: 87%
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“…The distribution tendencies of DA, 5-HT and GABA determined in rat brain were similar to those reported in previous studies (Bergh et al, 2016;González et al, 2011;Wojnicz et al, 2016). Levels of the inhibitory amino acid GABA were the most abundant of the three NTs, and were similar among the regions (around 300 μg/g), except in the hypothalamus (520 μg/g).…”
Section: Determination Of Nts In Rat Brain Samplessupporting
confidence: 87%
“…For the calibration curve preparation of surrogateanalyte approach, 10 μL of mixed working solution at different concentration levels and 150 μL of cold 0.1% FA in ACN (with IS) were spiked into 40 μL brain homogenate. For the calibration curve preparation for the surrogate-matrix approach, Ringer's solution (148 mM NaCl, 2.7 mM KCl, 1.2 mM CaCl 2 and 0.85 mM MgCl 2 ) was used as surrogate matrix for the brain homogenate (Bergh et al, 2016). The final concentrations of DA, 5-HT, DA-d4 and 5-HT-d4 were 0.5, 1, 5, 25, 100 and 200 ng/mL, respectively, while the concentrations of GABA and GABA-d6 were 1, 5, 25, 100, 200 and 500 ng/mL, respectively.…”
Section: Preparation Of Calibration Standards and Quality Control Smentioning
confidence: 99%
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