Validated potentiometric method for the determination of sulfacetamide sodium; application to its pharmaceutical formulations and spiked rabbit aqueous humor

Potentiometric Determination of Prednisolone in Pharmaceutical Formulations

“…The new electrode shows high linearity range and the little response time and short time of analysis. El-Rageh, et al [16] have reported the potentiometric determination of sulfacetamide Na in presence of prednisolone, with the comparison of their response time. It is clear that their proposed electrode is faster and having longer lifetime of 6 weeks [16].…”

“…Its therapeutic use is recommended for a variety of acute and chronic diseases, such as arthritis, allergic diseases, asthma, leprosy, and numerous other autoimmune and inflammatory diseases. Several methods based on liquid chromatography with UV detection have been reported [1][2][3][4][5][6][7][8][9][10][11][12], for the determination of prednisolone in plasma and some voltammetric methods have been developed [13][14][15][16]. Thus, the present method aimed at advocating of a new PRED-ISE as simple and accurate tool for the determination of prednisolone in authentic solutions, tablets and in spiked urine samples.…”

Multisensory Systems Based on Nafion Membranes Modified by PEDOT for the Determination of Sulfacetamide in Aqueous Solutions and Pharmaceuticals

“…Therefore, the developed multisensory system and a potentiometric sensor based on a PVC membrane with an ionophore described in the published sources [17] have close values of the working range of concentrations and error of determination of sulfacetamide anions, while the values of the limit of detection of sulfacetamide anions by an array of DP-sensors are by several orders of magnitude lower in comparison with those achieved in [17]. In addition, the working range of pH for a sensor based on PVC is lower than the pH of the solution of the pharmaceutical in the range of concentrations under study, because of which the adjustment of pH of the test object is required, while the calibration of the multisensory system takes into account the effect of the products of water dissociation on the response and makes it possible to perform the analysis in a wide range of pH as well as makes it pos- 6.43 5.0 × 10 -4 1.0 × 10 -3 (5.0 ± 0.3) × 10 -4 (0.96 ± 0.07) × 10 -3 0.9 4 7 9…”

“…Their use solves the problem of pollution and deactivation of the surface of electrodes by the products of transformations of analytes at high potentials as well as decreases the overvoltage of the electrode reaction and promotes the accumulation of the analyte on the electrode. When developing potentiometric sensors for the determination of sulfanylamides, the use of ion exchangers, in particular, plasticized polyvinylchloride (PVC) membranes with quaternary ammonium salts [15][16][17] or a complex of sodium sulfaquinoxaline with 2,3,5triphenyl tetrazolium chloride [18], is the most common. It should be noted that only one potentiometric sensor for the determination of sulfacetamide has been described in published sources [17].…”

“…When developing potentiometric sensors for the determination of sulfanylamides, the use of ion exchangers, in particular, plasticized polyvinylchloride (PVC) membranes with quaternary ammonium salts [15][16][17] or a complex of sodium sulfaquinoxaline with 2,3,5triphenyl tetrazolium chloride [18], is the most common. It should be noted that only one potentiometric sensor for the determination of sulfacetamide has been described in published sources [17]. The application of materials containing components with a conjugated π-system in potentiometric sensors for the determination of sulfanylamides is not presented in the published sources.…”