Validated specific HPLC-DAD method for simultaneous estimation of paracetamol and chlorzoxazone in the presence of five of their degradation products and toxic impurities

Simple simultaneous determination of moxifloxacin and metronidazole in complex biological matrices

“…Chromatographic analysis offers many advantages for the analysis of various compounds. [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] Thus, our proposed RP-HPLC method shows many advantages over the reported ones. It shows higher selectivity and sensitivity.…”

Rapid detection and quantification of paracetamol and its major metabolites using surface enhanced Raman scattering

“…The routine clinical use of paracetamol for a number of mild health conditions, has resulted in the application of many analytical tools for drug identification and quantification. These include chromatography, 13 spectrophotometry 14 and electrochemical analysis. 15 Chromatography, in particular liquid chromatography, is widely used in the pharmaceutical industry to characterise drugs and this is due to its high resolution, precision and accuracy.…”

Stability‐indicating method for quantification of potential genotoxic impurity and other organic impurities of chlorzoxazone using hyphenated techniques

“…2-Amino-4chlorophenol is a genotoxic impurity in nature; hence, the quantification of the same is to be more sensitive with respect to the adoption of available sophisticated techniques. A literature survey revealed that few analytical methods by high-performance thin layer chromatography (HPTLC)-UV [6], RP-HPLC [7], LC-mass spectrometry (MS)/MS [8,9], liquid chromatography-electrospray ionization-mass spectrometry [10], ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry [11], HPLC-DAD, and HPTLC [12,13] are available for the estimation of chlorzoxazone in dosage form and in human and rat plasma. A method is available for the quantification of chlorzoxazone and its impurities by the TLC method [14].…”