Validated Stability Indicating Spectrophotometric Methods for the Determination of Lidocaine Hydrochloride, Calcium Dobesilate, and Dexamethasone Acetate in their Dosage Forms

A comparative study of novel spectrophotometric resolution techniques applied for pharmaceutical mixtures with partially or severely overlapped spectra

“…Successive Spectrophotometric resolution technique [21][22][23] based on the use of smart original mathematical techniques utilizing the constants of which were previously applied for the analysis of binary mixture where the spectrum of one component was extended than the other [22]. Recently, the constants of the ratio spectra of either zero order absorption spectra as in ratio subtraction or derivative spectra as in derivative subtraction were applied successfully as resolution techniques for solving spectra [21].…”

“…Recently, the constants of the ratio spectra of either zero order absorption spectra as in ratio subtraction or derivative spectra as in derivative subtraction were applied successfully as resolution techniques for solving spectra [21]. In those resolution techniques the interference of one or more components in the mixtures was eliminated by applying stepwise elimination [22,28,29].…”

“…Successive resolution technique [21][22][23] based on the use of smart original mathematical techniques utilizing the constants which were previously applied for the analysis of binary mixture where the spectrum of one component was extended than the other using either ratio subtraction method [21,[25][26][27] or its newly developed extension namely spectrum subtraction [27], while the resolution technique based on derivative technique was introduced for the analysis of severely overlapped spectra of multi component dosage forms whether ternary or more, or as mixtures with their degradation products [22] which improved resolution bands, eliminated the influence of interfering components and minimized the degree of overlapping so partially overlapped spectra were obtained thus improving the performance of the proposed methods to achieve the complete resolution [21].…”

“…In this work, two recently introduced resolution techniques were applied namely successive [21][22][23] and progressive resolution techniques [24][25][26]. The resolution of spectra of the cited drugs can be achieved via those techniques based on the use of smart original mathematical techniques where successive techniques consist of several consecutive steps utilizing ratio of zero order absorption and/or derivative spectra while, progressive resolution consists of single manipulation step.…”

Spectral analysis of overlapped absorption bands of binary mixtures—an application on combination of pseudoephedrine sulphate and loratadine mixture

“…Dual-wavelength method for PSE (DW) The selection of two wavelengths in which the interfering element shows equal value of absorbance, and the desired element differs significantly in the value of the absorbance with concentration is very important factor to apply dual-wavelength method [43,44]. As selection of suitable wavelengths regarding sensitivity and selectivity is vital, so different wavelengths were examined, and it was found that the best results concerning sensitivity and selectivity were obtained through the absorbance difference at 254 nm and 273 nm for determination of PSE where LOR shows zero absorbance difference (Fig.…”