Validated Uv Spectroscopic Method for Estimation of Zolmitriptan From Tablet Formulations

Abstract

A simple, economical, sensitive and specific UV spectrophotometric method was developed for the estimation of Zolmitriptan in bulk drug tablet dosage form. The optimum conditions for the analysis of the drug were established. The wavelength maxima (λmax) for zolmitriptan were found to be 226.5 nm. The linearity for this method was found to be in the range of 1-5µg/ml. The method showed high sensitivity with reproducibility in results. The lower limit of detection and the limit of quantification were found to be 4.234and 12.702 respectively. The calibration curve was drawn by plotting graph between absorbance and concentration. Coefficient of correlation was 0.99. The regression of the curve was Y = 0.1751x +0.0476. Precision of the method was found to be 1.625 ± 0.324 against the label claim of 2.5mg. The percentage recovery was found to be 98.66 -99.50. The sample solution was stable up to 12 hours. The proposed method may be suitably applied for the analysis of Zolmitriptan in tablet pharmaceutical formulation for routine analysis

Development and Validation of HPLC Method for Estimation of Zolmitriptan in its Pharmaceutical Dosage Form

“…Zolmitriptan is a selective 5-hydroxytryptamine 1B/1D (5-HT1B/1D) receptor agonist. Several methods for the estimation of Zolmitriptan have been described in the literature which include spectrophotometric method [1][2][3], High-Performance Liquid Chromatography (HPLC) method [4][5][6], colorimetry [7], capillary chromatography [8,9], differential pulse and square wave voltammetry [10,11]. While HPLC methods were reported for the determination of zolmitriptan in human plasma using fluorescence detection, liquid chromatography-electrospray mass spectrometry [12,13], coulometric detection [14].…”