Emulators are widely used to build dynamic analysis frameworks due to its fine-grained tracing capability, full system monitoring functionality, and scalability of running on different operating systems and architectures. However, whether emulators are consistent with real devices is unknown. To understand this problem, we aim to automatically locate inconsistent instructions, which behave differently between emulators and real devices.We target the ARM architecture, which provides machine-readable specifications. Based on the specification, we propose a sufficient test case generator by designing and implementing the first symbolic execution engine for the ARM architecture specification language (ASL). We generate 2,774,649 representative instruction streams and conduct differential testing between four ARM real devices in different architecture versions (i.e., ARMv5, ARMv6, ARMv7, and ARMv8) and three state-of-the-art emulators (i.e., QEMU, Unicorn, and Angr). We locate a huge number of inconsistent instruction streams (171,858 for QEMU, 223,264 for unicorn, and 120,169 for Angr). We find that undefined implementation in ARM manual and bugs of emulators are the major causes of inconsistencies. Furthermore, we discover 12 bugs, which influence commonly used instructions (e.g., BLX). With the inconsistent instructions, we build three security applications and demonstrate the capability of these instructions on detecting emulators, anti-emulation, and anti-fuzzing.