Validation and applications of an expedited tablet friability method

Osei-Yeboah, Frederick; Sun, Changquan Calvin

doi:10.1016/j.ijpharm.2015.02.061

Cited by 83 publications

(29 citation statements)

References 32 publications

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“…For weight variation, 20 tablets was taken randomly and weighed on an electronic weighing balance (Shimadzu Gmbh, Germany), their average weight was calculated and in the end, the individual weight was compared with average weight . Friability (equation ) of tablets was determined by using Roche friabilator for 4 min at the rate of 25 rpm

Friability = \frac{W_{normalinitial - W_{final}}}{W_{initial}} \times 00

…”

Section: Methodsmentioning

confidence: 99%

pH‐responsive alginate–pectin polymeric rafts and their characterization

Hanif

Abbas

2017

Adv Polym Technol

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Aim of the present work was to develop alginate-pectin rafts by using box behnken design to provide symptomatic relief from gastroesophageal reflux disorders by forming floating gel or raft on the top of gastric contents. Sodium alginate and pectin were used as raft-forming polymers, sodium bicarbonate as gas-generating substance, and calcium carbonate for generation of calcium ions. Physical test of all compressed formulations were within pharmacopoeial limits. Effect of pH of medium on raft formation was observed by placing the formulation in different pH mediums. Raft was characterized by their strength, weight, volume, resilience, reflux resistance, thickness, buffering capacity, neutralizing capacity, floating lag time (FLT) and total floating time (TFT). Fourier transform infrared (FTIR) spectroscopy was performed to check the interaction between the polymers and other excipients.Raft was effectively formed at pH 1.2. Raft strength, reflux resistance, and thickness of optimized formulation APR15 were 9.71 ± 0.013 g, 2670 ± 0.987 g, and 5.1 ± 0.045 cm, respectively. Raft resilience for the APR15 was found to be greater than 480 min. TFT of APR15 was greater than 8 hr with 50 s FLT. Buffering and neutralizing capacity were 12.70 ± 1.21 meq and 7.0 ± 0.34 meq, respectively. FTIR spectra showed no interactions between sodium alginate, pectin, and other excipients. This study demonstrated that alginate-pectin rafts are suitable for the treatment of gastro-esophageal reflux disorders. K E Y W O R D Sbox behnken design, pectin, raft, sodium alginate

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Friability = \frac{W_{normalinitial - W_{final}}}{W_{initial}} \times 00

…”

Section: Methodsmentioning

confidence: 99%

pH‐responsive alginate–pectin polymeric rafts and their characterization

Hanif

Abbas

2017

Adv Polym Technol

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“…Fifteen preweighed tablets were placed in the friabilator, which was then operated for 100 revolutions. The tablets were then deducted and reweighed 22 . The friability was computed by following formula: F = 100 (1-W 0 /W) W 0 : Initial weight, W: Weight after friability testing.…”

Section: Fig 1: Schematic Presentation Of Angle Of Repose Determinationmentioning

confidence: 99%

Untitled

2018

IJPSR

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Effervescent tablet is a convenient oral dosage form, which has special ingredients. This potency of effervescent tablet helps to delivered drugs, effectively. Medicinal plants have a wide range of usage in the world. Mespilus germanica (Rosaceae) and Quercus castaneifolia (Fagaceae) are important medicinal plants used in several diseases such as diarrhea. Medlar and oak, the fruits of M. germanica and Q. castaneifolia respectively, were harvested and extracted using hydro-acetonic solvent by maceration method. In addition, total phenol and tannin contents were assayed using Folin-Ciocalteu method. Antimicrobial activity of extract was determined using broth dilution test on some intestinal pathogens. Finally, effervescent tablets were prepared using wet granulation method and analyzed. Total phenols and tannins were obtained 0.9% and 0.1% respectively. This reduces the amounts of total tannins will disappear with adding antioxidant agents. Tablet hardness, friability and disintegration time were significantly dependent on the amounts of lubricant, acidifying and alkalizing agents. This work investigated the potential of developing Oak and Medlar effervescent tablets to facilitate drug administration and mask drug taste. This formula may be encouraging in improving patient compliance and drug efficiency.

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“…Tablet friability profile, that is, tablet weight loss as a function of compaction force, of each formulation was carried out using an expedited method. 16 The expedited friability test used a set of 15-20 tablets prepared for each formulation under different compaction forces using any tablet tooling (oval shaped in this study). After recording the weight of individual tablets, the coded tablets were loaded into a friabilator (Pharma Alliance Group Inc., Model F2, Valencia, CA), which was allowed to run at 25 rpm for 4 min.…”

Section: Characterization Of Tabletsmentioning

confidence: 99%

“…The compaction force corresponding to 0.8% tablet weight loss was then identified. 16 A batch of tablets was then made at a force slightly above the identified compression force for further evaluation of tablet quality attributes, including friability as per the United States Pharmacopeia (USP).…”

Section: Characterization Of Tabletsmentioning

confidence: 99%

“…The problem is solved by the recent introduction of an expedited method to efficiently assess the friability of compacted materials. 16 In this method, the optimum compaction force required to pass the friability test is determined from an experimentally determined friability plot. This approach avoids the possible problems induced by excessive compaction pressure, such as overcompression and phase transformation of APIs that may alter the stability and bioavailability of the drug.…”

Section: Identifying Optimum Compaction Force Based On Friabilitymentioning

confidence: 99%

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Enabling the Tablet Product Development of 5-Fluorocytosine by Conjugate Acid Base Cocrystals

Perumalla

Paul

Sun

2016

Journal of Pharmaceutical Sciences

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5-Fluorocytosine (FC) is a high-dose antifungal drug that challenges the development of a tablet product due to poor solid-state stability and tabletability. Using 2 pharmaceutically acceptable conjugate acid base (CAB) cocrystals of FC with HCl and acesulfame, we have developed commercially viable high loading FC tablets. The tablets were prepared by direct compression using nano-coated microcrystalline cellulose Avicel PH105 as a tablet binder, which provided both excellent tabletability and good flowability. Commercial manufacturability of formulations based on both CAB cocrystals was verified on a compaction simulator. The results from an expedited friability study were used to set the compaction force, which yielded tablets with sufficient mechanical strength and rapid tablet disintegration. This work demonstrates the potential value of CAB cocrystals in drug product development.

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Validation and applications of an expedited tablet friability method

Cited by 83 publications

References 32 publications

pH‐responsive alginate–pectin polymeric rafts and their characterization

pH‐responsive alginate–pectin polymeric rafts and their characterization

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Enabling the Tablet Product Development of 5-Fluorocytosine by Conjugate Acid Base Cocrystals

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