Validation of a chemical osteoarthritis model in rabbit temporomandibular joint: a compliment to biomechanical models

Clèdes, Géraldine; Felizardo, Rufino; Foucart, Jean‐Michel; Carpentier, Pierre

doi:10.1016/j.ijom.2006.05.003

Cited by 35 publications

(39 citation statements)

References 18 publications

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“…In the present study, we observed few phenotypic changes in condylar cartilage. In contrast, osteoarthritic changes have been reported to take place in condylar cartilage and subchondral bone, including clefts and erosions, when CFA is injected into the inferior joint compartment (Cledes et al, 2006;Kuroki et al, 2011). Comparison of temporal phenotypes of double CFA injections in the superior and inferior compartments is warranted.…”

Section: Discussionmentioning

confidence: 99%

Sustained Inflammation Induces Degeneration of the Temporomandibular Joint

et al. 2012

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Section: Discussionmentioning

confidence: 99%

Sustained Inflammation Induces Degeneration of the Temporomandibular Joint

et al. 2012

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“…In both cases, TMJ is a diarthrosis (synovial) joint with an articular disc (Herring 2003, Cledes et al 2006, Vasconcellos et al 2007, Fuentes et al 2016.…”

Section: Discussionmentioning

confidence: 99%

“…Although in basic biology, the species of animal used in relation to the response of mesenchymal cells is similar in all cases, the use of rats as an experimental model for research and development of pathologies of the ATM is important, not only for achieving an experimental reproducibility as close to the human ATM, but also for the use of a reduced number of animals, obtaining the maximum benefit and allowing the anatomy of the TMJ to be faithfully reproduced (Herring 2003, Cledes et al 2006.…”

Section: Discussionmentioning

confidence: 99%

“…The use of spontaneous or surgical methods for the development of OA was reduced due to the limited availability of special animals, the slow progression of the disease, and the high complexity in surgical intervention (Bendele 2001, Cledes et al 2006. For these reasons, the method of intra-articular injection of monosodium iodine acetate (MIA) to induce lesions of osteoarthritis is widely used to induce OA of the knee (Guingamp et al 1997, Guzman et al 2003, Wang et al 2012.…”

Section: Introductionmentioning

confidence: 99%

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Injection in temporomandibular joint of rats. Description of technical protocol

Fuentes¹,

Veuthey²,

Arias³

et al. 2017

Polish Journal of Veterinary Sciences

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The development of animal models for research has been very diffused. Osteoarthritis is a joint degenerative pathology that induces cartilage erosion, chondrocyte proliferation and osteophyte formation. The aim of this paper is to present a technical procedure to perform the injection of monosodium iodine acetate in the temporomandibular joints of rats to generate osteoarthritis and to contribute to future research analysis related to pathology progression and proper treatment performance. The use of rat models may be a complex process because of their size, but they can be compared to the human temporomandibular joint due to the similar characteristics and the possibility of performing diagnosis and treatment protocols in order to detect this pathology.

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“…Histopathological characteristics include a progressive degeneration of the articular cartilage (Cledes et al, 2006), fibrillation and erosion of the articular surfaces, proliferation of chondrocytes, eburnation of the articular cartilage, synovitis, changes and exposure in the subchondral bone and formation of osteophytes at the articular margin (Cledes et al; Güler et al). The imbalance occurs between the process of synthesis and degradation within the chondrocytes, which leads to the loss of cartilaginous tissue.…”

Section: Characteristics Of the Temporomandibular Jointmentioning

confidence: 99%

Role of Hyaluronic Acid in the Homeostasis and Therapeutics of Temporomandibular Joint Osteoarthritis

et al. 2017

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Morphol., 35(3):870-876, 2017. SUMMARY:The aim of this study was to perform a literature review regarding the role of hyaluronic acid (HA) in the homeostasis and therapeutics of temporomandibular joint (TMJ) osteoarthritis (OA). The TMJ has characteristics that give it special adaptation and recovery abilities, where HA plays a fundamental role in helping to maintain joint homeostasis, which is affected in pathological processes like OA. OA is a chronic degenerative multi-factor disease that can affect all the components of the synovial joints, causing degradation of the articular cartilage, extracellular matrix and breakage in the HA molecules. HA is a non-branched linear polysaccharide with viscosupplementation, anti-inflammatory, lubrication and pain relief effects; it also activates the intrinsic repair processes of the cartilage and normalizes the endogenous production of HA by the synoviocytes. In recent years, the therapeutic use of HA has shown evidence that supports its application in TMJ OA, improving viscosupplementation capacity, acting at the cellular and molecular levels, reducing various inflammatory mediators and improving the reparative characteristics. Its use has been studied in animal models and in humans. However, no consensus has been reached in terms of concentrations, dose, application frequency or molecular weight to be used.

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Validation of a chemical osteoarthritis model in rabbit temporomandibular joint: a compliment to biomechanical models

Cited by 35 publications

References 18 publications

Sustained Inflammation Induces Degeneration of the Temporomandibular Joint

Sustained Inflammation Induces Degeneration of the Temporomandibular Joint

Injection in temporomandibular joint of rats. Description of technical protocol

Role of Hyaluronic Acid in the Homeostasis and Therapeutics of Temporomandibular Joint Osteoarthritis

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