2021
DOI: 10.3389/fphys.2020.600551
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Validation of a Portable Blood Gas Analyzer for Use in Challenging Field Conditions at High Altitude

Abstract: BackgroundNovel, portable blood gas analyzers (BGAs) may serve as essential point-of-care tools in remote regions, during air travel or in ambulance services but they have not been extensively validated.Research QuestionWe compared accuracy of a portable BGA to a validated stationary device.MethodsIn healthy individuals and patients with chronic obstructive pulmonary disease participating in clinical field studies at different altitudes, arterial blood samples were obtained at rest and during exercise in a hos… Show more

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Cited by 7 publications
(6 citation statements)
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References 13 publications
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“…A total of ~2 mL of venous blood was collected in a lithium-heparinized syringe during each draw. The sample first underwent blood-gas analysis by a validated point-of-care analyzer (EPOC; Siemens Healthineers, Ontario, Canada) (23). Next, a drop of whole venous blood was applied to point-of-care analyzer to determine [β-hydroxybutyrate] (β-ketone test strips, Freestyle Precision Neo; Abbott Laboratories, Abbott Park, IL).…”
Section: Methodsmentioning
confidence: 99%
“…A total of ~2 mL of venous blood was collected in a lithium-heparinized syringe during each draw. The sample first underwent blood-gas analysis by a validated point-of-care analyzer (EPOC; Siemens Healthineers, Ontario, Canada) (23). Next, a drop of whole venous blood was applied to point-of-care analyzer to determine [β-hydroxybutyrate] (β-ketone test strips, Freestyle Precision Neo; Abbott Laboratories, Abbott Park, IL).…”
Section: Methodsmentioning
confidence: 99%
“…To the best of our knowledge, this research represents the widest validation study of such non-invasive gas exchange assessment method in a homogenous cohort of hypoxemic patients with moderate-to-severe COPD, following a short high-altitude exposure. The main findings indicate the ability of the AGM100 to predict PaO 2 (with an absolute low mean bias of 2 mmHg versus measured PaO 2 with a previously validated point-of-care analyzer [20]) and the satisfying diagnosis predictive performance (Table 4) of this device to diagnose severe resting hypoxemia. Moreover, the AGM100 provides an estimation of the pulmonary gas exchange efficacy through the O 2 deficit.…”
Section: Discussionmentioning
confidence: 75%
“…Sensitivity analysis: since aBGA point-of-care devices as EPOC may not be considered as accurate as stationary devices, we conducted a sensitivity analysis for PaO 2 and A-aDO 2 agreements, using a corrected value of mPaO 2 computed from the regression equation developed in a previous validation study of the EPOC, conducted in similar field conditions [20].…”
Section: Discussionmentioning
confidence: 99%
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