2015
DOI: 10.1007/s11626-015-9889-8
|View full text |Cite
|
Sign up to set email alerts
|

Validation of an in vitro model of erbB2+ cancer cell redirection

Abstract: Overexpression of the oncoprotein erbB2/HER2 is present in 20-30% of breast cancer patients and inversely correlates with patient survival. Reports have demonstrated the deterministic power of the mammary microenvironment where the normal mammary microenvironment redirects cells of non-mammary origin or tumor-derived cells to adopt a mammary phenotype in an in vivo model. This phenomenon is termed tumor cell redirection. Tumor-derived cells that overexpress the erbB2 oncoprotein lose their tumor-forming capaci… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
18
0

Year Published

2017
2017
2021
2021

Publication Types

Select...
7

Relationship

2
5

Authors

Journals

citations
Cited by 10 publications
(18 citation statements)
references
References 44 publications
0
18
0
Order By: Relevance
“…These results suggest that cancer cells are responsive to external stimuli and can even be reverted back to the wild-type tissue phenotype by the signaling from cells within a healthy environment. This phenomenon has been termed "cancer cell redirection" [6].…”
Section: Introductionmentioning
confidence: 99%
“…These results suggest that cancer cells are responsive to external stimuli and can even be reverted back to the wild-type tissue phenotype by the signaling from cells within a healthy environment. This phenomenon has been termed "cancer cell redirection" [6].…”
Section: Introductionmentioning
confidence: 99%
“…Not only are mouse tumor-derived cells susceptible to redirection [ 8 , 11 ] but human breast cancer and embryonic testicular carcinoma cells have been redirected [ 9 10 ]. Both human female and male derived cancer cells differentiated into functional breast epithelial cells in response to signals from the normal mouse mammary microenvironment [ 8 11 ]. This suggests that human cancers are reactive to controlling intercellular signals present in developing mammalian tissues.…”
Section: Discussionmentioning
confidence: 99%
“…Establishment of the MMTV-neu cell lines is described elsewhere [ 11 ]. MMTV-neu cells were maintained in DMEM supplemented with 10% FBS and 1% antibiotic/antimycotic.…”
Section: Methodsmentioning
confidence: 99%
See 2 more Smart Citations