Using uncertainty quantification techniques, we carry out a sensitivity analysis of a large number (17) of parameters used in the NCAR CAM5 cloud parameterization schemes. The LLNL PSUADE software is used to identify the most sensitive parameters by performing sensitivity analysis. Using Morris One-At-a-Time (MOAT) method, we find that the simulations of global annual mean total precipitation, convective, large-scale precipitation, cloud fractions (total, low, mid, and high), shortwave cloud forcing, longwave cloud forcing, sensible heat flux, and latent heat flux are very sensitive to the threshold-relative-humidity-for-stratiform-low-clouds ($$rhminl)$$
r
h
m
i
n
l
)
and the auto-conversion-size-threshold-for-ice-to-snow $$\left( {dcs} \right).$$
dcs
.
The seasonal and regime specific dependence of some parameters in the simulation of precipitation is also found for the global monsoons and storm track regions. Through sensitivity analysis, we find that the Somali jet strength and the tropical easterly jet associated with the south Asian summer monsoon (SASM) show a systematic dependence on $$dcs$$
dcs
and $$rhminl$$
rhminl
. The timing of the withdrawal of SASM over India shows a monotonic increase (delayed withdrawal) with an increase in $$dcs$$
dcs
. Overall, we find that $$rhminl$$
rhminl
, $$dcs$$
dcs
, $$ai,$$
a
i
,
and $$as$$
as
are the most sensitive cloud parameters and thus are of high priority in the model tuning process, in order to reduce uncertainty in the simulation of past, present, and future climate.