Statistical process control is a method used for controlling processes in which causes of variations and correction actions can be observed. Control chart is one of the powerful tools of statistical process control that are used to control nonconforming products. Previous literature suggests that fuzzy charts are more sensitive than conventional control charts, and hence, they provide better quality and conformance of products. Nevertheless, some of the data used are more suitable to be presented in interval type-2 fuzzy numbers compared to type-1 fuzzy numbers as interval type-2 fuzzy numbers have more ability to capture uncertain and vague information. In this paper, we develop an interval type-2 fuzzy standardized cumulative sum (IT2F-SCUSUM) control chart and apply it to data of fertilizer production. This new approach combines the advantages of interval type-2 fuzzy numbers and standardized sample means which can control the variability. Twenty samples with a sample size of six were examined for testing the conformance. The proposed IT2F-SCUSUM control chart unveils that 15 samples are “out of control.” The results are also compared to the conventional CUSUM chart and type-1 fuzzy CUSUM chart. The conventional chart shows that 13 samples are “out of control.” In contrast, the type-1 fuzzy CUSUM chart shows that the process is “out of control” for 14 samples. In the analysis of average run length, the proposed IT2F-SCUSUM chart outperforms the other two CUSUM charts. Thus, we can conclude that the IT2F-SCUSUM chart is more sensitive and takes lesser number of observations to identify the shift in the process. The analyses suggest that the IT2F-SCUSUM chart is a promising tool in examining conformance of the quality of the fertilizer production.