High-resolution observations of typhoon boundary layer above 100 m are rare as traditional wind towers are generally below 100 m, which limits the study of typhoon boundary layer and engineering applications such as wind-resistant design of tall buildings and wind turbines in typhoon-prone regions. In this study, boundary layer winds of super typhoon Lekima (2019) are observed, simulated and analyzed. Together with traditional wind tower, Doppler wind lidar is utilized for observations of typhoon boundary layer in order to obtain measured data above 100 m. Besides, Computational Fluid Dynamics (CFD) simulation based on Large Eddy Simulation (LES) method is conducted to further investigate the impact of complex terrain on the near-surface wind characteristics. The results show that the power law fits the mean wind speed profile well below 100 m. However, before and after the typhoon lands, a local reverse or low-level jet occurs in the mean wind speed profile at the height of 100–300 m, which cannot be depicted by the power law. Meanwhile, the turbulence intensity increases with height and experiences larger fluctuations. In addition, there is a significant negative correlation between the ground elevation and power exponents of the fitted mean wind speed profiles. This study provides useful information to better understand wind characteristics of the typhoon boundary layer.