Validation of droplet-generation performance of a newly developed microfluidic device with a three-dimensional structure

Nozaki, Yoshito; Yoon, Dong Hyun; Furuya, Masahiro; Fujita, Hiroyuki; Sekiguchi, Tetsushi; Shoji, Shuichi

doi:10.1016/j.sna.2021.112917

Cited by 7 publications

(8 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another design of a 3D microfluidic device is presented by Nozaki et al [ 86 ], who have developed a platform in which the dispersed phase is broken up by the shear stress of the continuous phase coming from eight directions ( Figure 26 ). The device has one round inlet for the dispersed phase, eight rectangular inlets for the continuous phase, and one round outlet for observation and collection of the generated droplets.…”

Section: Geometriesmentioning

confidence: 99%

“…In this respect, numerous studies have focused on fabricating microfluidic devices, performing numerical simulations, analyzing fluid movement, and testing the developed microchips in experimental syntheses. Researchers worldwide managed to exploit the advantages of microfluidic technology for generating microdroplets [ 44 , 53 , 59 , 72 , 80 , 85 , 86 , 87 , 88 ], porous films [ 45 ], double emulsion droplets [ 55 ], nanofibers [ 69 ], microcapsules [ 82 , 83 ], and micro- [ 32 , 56 , 57 , 58 , 70 , 77 , 82 ] and nanoparticles of various compositions, sizes, shapes and morphologies [ 6 , 42 , 50 , 52 , 54 , 60 , 61 , 65 , 66 , 68 , 74 , 76 , 78 , 84 ].…”

Section: Geometriesmentioning

confidence: 99%

“… Schematics and dimensions of the microfluidic device designed by Nozaki et al Reprinted from an open-access source [ 86 ]. …”

Section: Figurementioning

confidence: 99%

See 2 more Smart Citations

A Review of Microfluidic Experimental Designs for Nanoparticle Synthesis

Niculescu

Mihăiescu

Grumezescu

2022

IJMS

View full text Add to dashboard Cite

Microfluidics is defined as emerging science and technology based on precisely manipulating fluids through miniaturized devices with micro-scale channels and chambers. Such microfluidic systems can be used for numerous applications, including reactions, separations, or detection of various compounds. Therefore, due to their potential as microreactors, a particular research focus was noted in exploring various microchannel configurations for on-chip chemical syntheses of materials with tailored properties. Given the significant number of studies in the field, this paper aims to review the recently developed microfluidic devices based on their geometry particularities, starting from a brief presentation of nanoparticle synthesis and mixing within microchannels, further moving to a more detailed discussion of different chip configurations with potential use in nanomaterial fabrication.

show abstract

Section: Geometriesmentioning

confidence: 99%

Section: Geometriesmentioning

confidence: 99%

See 1 more Smart Citation

A Review of Microfluidic Experimental Designs for Nanoparticle Synthesis

Niculescu

Mihăiescu

Grumezescu

2022

IJMS

View full text Add to dashboard Cite

show abstract

“…2013; Nozaki et al. 2021). Important to mention here is that the paradigm of droplet-based microfluidics has shown significant technical and research potential specifically due to its suitability in point-of-care diagnostics (Shamloo & Hassani-Gangaraj 2020), drug delivery (Yue et al.…”

Section: Introductionmentioning

confidence: 99%

“…Droplet-based microfluidics has gained widespread attention among researchers for the past two decades, owing to its capability of precise control of minute volumes (Manga 1996;Adamson et al 2006;Baroud, Gallaire & Dangla 2010;Vladisavljević et al 2013;Nozaki et al 2021). Important to mention here is that the paradigm of droplet-based microfluidics has shown significant technical and research potential specifically due to its suitability in point-of-care diagnostics (Shamloo & Hassani-Gangaraj 2020), drug delivery (Yue et al 2020), analysing and screening of bio/chemical reaction products (Zheng & Ismagilov 2005) and many more related areas (Moon et al 2010;Santos et al 2016;Madadelahi, Ghazimirsaeed & Shamloo 2019).…”

Section: Introductionmentioning

confidence: 99%

Magnetofluidic-based controlled droplet breakup: effect of non-uniform force field

2022

View full text Add to dashboard Cite

We report the breakup dynamics of a magnetically active (ferrofluid) droplet in a T-shaped Lab on a Chip (LOC) device under the modulation of a non-uniform magnetic field. We adhere to high-speed imaging modalities for the experimental quantification of the droplet splitting phenomenon, while the underlying phenomenon is supported by the numerical results in a qualitative manner as well. On reaching the T-junction divergence, the droplet engulfs the intersection fully and eventually deforms into the dumbbell-shaped form, making its bulges move towards the branches of the junction. We observe that the asymmetric distribution of the magnetic force lines, acting over the T-junction divergence, induces an accelerating motion to the left of the moving bulge (since the magnet is placed adjacent to the left branch). We show that the non-uniform force field gradient allows the formation of a hump-like structure inside the left moving bulge, which triggers the onset of augmented convection in its flow field. We reveal that this augmented internal convection developed in the left moving volume/bulge, on becoming coupled to the various involved time scales of the flow field, leads to the asymmetric splitting of the droplet into two sister droplets. Our analysis establishes that, at the critical strength of the applied forcing, as realized by the critical magnetic Bond number, the flow time scale becomes minimum at the left branch of the channel, leading to the formation of larger sized sister droplets therein. Inferences of the present analysis, which demonstrates a plausible means of independently controlling the size of the sister droplet by manoeuvring the applied force field gradient, will provide a potential solution for rapid droplet splitting, which typically finds significant importance in point-of-care diagnostics.

show abstract