Validation of ethnomedicinal potential of Tinospora cordifolia for anticancer and immunomodulatory activities and quantification of bioactive molecules by HPTLC

Bala, Manju; Pratap, Kunal; Verma, Praveen Kumar; Singh, Bikram; Padwad, Yogendra

doi:10.1016/j.jep.2015.08.001

Cited by 79 publications

(55 citation statements)

References 17 publications

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“…It is also said that the nature exhibited outwardly is dependent on the genetic makeup of the plant and the knowledge about such genetic makeup helps us understand the plants and their nature better. This understanding at genetic level is better achieved by using biotechnology techniques and genetic techniques like PCR, RFLP, Genome studies and various other scientific techniques [16]. The reversion back to the age old medicines to face and counter act the current and challenging problems is the testimony in the strength and endurance that the medicinal plants possess and hold on to.…”

Section: Resultsmentioning

confidence: 99%

“…The most admirable character of the plant extract is the effect it bears in the cognitive field; its ability to affect the learning and memory cortex of the human intelligence is an admirable trait and this trait has attracted the interest of various scientific and industrial bodies. The plant also bears anti-oxidant, anti-inflammatory, anti-tuberculosis; wound healing, immunomodulatory and immunoprotective, hepatoprotective, anti-osteoporotic, anti-cancer, anti-tumor, antimalaria, cardio protective nature and many more properties that make them a topic of great importance and interest [5][6][7][12][13][14][15][16][17][18][19]. Their effect on the fat and lipid metabolism and the rate of blood fat deposition is observed to be a direct or indirect reason for the expression of many activities mentioned above.…”

Section: Medicinal and Therapeutic Propertiesmentioning

confidence: 99%

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Tinospora cordifolia: The Antimicrobial Property of the Leaves of Amruthaballi

Basalingappa¹

2017

JBMOA

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Medicinal plants are known for their bioactive compound which is responsible for various beneficial characters, in this case, anti-microbial character. In this paper, the anti-microbial character of shade dried and powdered T. cordifolia leaves were tested and observed against a test microorganism Escherichia coli. Three different solvent extracts, i.e. ethanolic, methanolic and aqueous extracts of the leaf were taken and then tested for their degree of anti-microbial nature against E. coli using slip disc method. The degree of the character of the plant extract was inferred by the comparative studies of the zone of inhibition (in mm diameter). The results observed from the experiment prove to us that the natural medicinal character of the climber is an economical alternative form of medicine compared to the currently used ones, with fewer side effects to the consumers and easy availability.

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Section: Resultsmentioning

confidence: 99%

Section: Medicinal and Therapeutic Propertiesmentioning

confidence: 99%

Tinospora cordifolia: The Antimicrobial Property of the Leaves of Amruthaballi

Basalingappa¹

2017

JBMOA

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“…The protective efficacy of natural antioxidants is higher than the laboratory synthesized antioxidants due to relatively more bioavailability of antioxidants from the natural plant sources [50]. It was reported that secondary metabolites obtained from T. cordifolia work against the four different cancer cell lines [51]; in addition to these, it may be antimutagenic and effective against various virus-related diseases including HIV [52].…”

Section: Discussionmentioning

confidence: 99%

Genoprotective Effects of Ethanolic Stem Extracts of Tinospora Cordifolia on Sodium Arsenite-Induced Dna Damage in Swiss Mice Lymphocytes by Comet Assay

Shashikant

2019

Asian J Pharm Clin Res

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Objective: The study was aimed to evaluate the DNA protective effects of ethanolic extracts of Tinospora cordifolia stem on Swiss albino mice lymphocytes against the sodium arsenite-induced genotoxicity. Methods: In this experiment, 25 animals of nearly the same age were equally divided. Group 1 (control) fed on tap water while rest four (2, 3, 4, and 5) groups were treated with 4 mg/kg body weight, per orally sodium arsenite for 12 weeks. Sodium arsenite pretreated groups (4 and 5) were followed by administration of 80 mg/kg body weight, per orally T. cordifolia extracts for the next 12 weeks. Animals were sacrificed at the 8th week and 12th week, respectively, for the assessment of sodium arsenite-induced genotoxicity and comparative genoprotective effects of experimental plant extracts. The extent of DNA migration is directly proportional to the magnitude of DNA damage. Percentage tail DNA content and olive tail moment parameters were used in the comet to relate DNA damage. Results: The findings suggested that the ethanolic stem extracts of T. cordifolia significantly inhibited the sodium arsenite-induced oxidative genotoxicity. The phytoconstituents of T. cordifolia shown to retard genetic damage associated with arsenic exposure. Conclusion: T. cordifolia may be used as a preventive herbal preparation against chemical or arsenical toxicity.

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“…Bala M et al used 2 kg of dried stem in 80% ethanol extract. They extracted three phytocomponents and elicited an IC 50 value of less than 100 µg/ml [9]. Maliakkal et al used 2 kg of the dried crushed stem through alcohol extract and observed a dose which depended on cytotoxicity, with an ideal IC 50 value of less than 100 µg/mL.…”

Section: Dose Effect Of Phytocomponentsmentioning

confidence: 99%

Effect of Tinospora cordifolia-Derived Phytocomponents on Cancer: A Systematic Review

et al. 2019

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The major cancer therapeutic modalities include surgery, chemotherapy and radiotherapy. Although these treatment regimens have played a significant role in effectively inhibiting cancer, their associated morbidity reduces the overall quality of life. Thus, researchers are striving to identify any alternate therapeutic approach capable of inhibiting cancer without eliciting the added morbidity. Among the alternate cancer therapeutics being researched, much importance is being given to the use of plants due to the presence of a wide variety of anti-carcinogenic compounds. Tinospora cordifolia (Tc) is one such plant and has shown to exhibit anti-carcinogenic properties. The present review aimed to systematically analyze published data on the effect of Tinospora cordifolia-derived phytocomponents on cancer. PubMed, Scopus, Web of Science, Embase and Cochrane library were searched using the keywords Tinospora cordifolia; anticancer; phytocomponents until March 20, 2019. In vivo and in vitro original studies in the English language were included. Of the 342 articles identified, only 25 articles met the selection criteria and were included in the review. Significant anti-carcinogenic properties were exhibited by Tinospora cordifolia-derived phytocompounds including palmative, berberine, new clerodane furanoditerene glycoside, arabinogalactan, phenolic compounds and epoxy cleodane diterpene. No significant side effects have been elicited with its use. Based on the data from the included studies, Tinospora cordifolia could be a natural therapeutic agent for cancer, provided its anti-carcinogenic properties can be elicited consistently at a large scale in clinical trials.

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Validation of ethnomedicinal potential of Tinospora cordifolia for anticancer and immunomodulatory activities and quantification of bioactive molecules by HPTLC

Cited by 79 publications

References 17 publications

Tinospora cordifolia: The Antimicrobial Property of the Leaves of Amruthaballi

Tinospora cordifolia: The Antimicrobial Property of the Leaves of Amruthaballi

Genoprotective Effects of Ethanolic Stem Extracts of Tinospora Cordifolia on Sodium Arsenite-Induced Dna Damage in Swiss Mice Lymphocytes by Comet Assay

Effect of Tinospora cordifolia-Derived Phytocomponents on Cancer: A Systematic Review

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