2014
DOI: 10.1111/1469-0691.12401
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Validation of microscopic observation drug susceptibility testing for rapid, direct rifampicin and isoniazid drug susceptibility testing in patients receiving tuberculosis treatment

Abstract: Drug susceptibility testing (DST) is often needed in patients clinically failing tuberculosis (TB) therapy. Most studies of phenotypic direct drug susceptibility tests, such as microscopic observation drug susceptibility (MODS) tests, have been performed in patients not receiving TB treatment. The effect of ongoing TB treatment on the performance of MODS direct DST has not been previously explored, but patients failing such therapy constitute an important target group. The aim of this study was to determine th… Show more

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Cited by 4 publications
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“…Being able to obtain the results of drug susceptibility testing within 8 days and the possibility of also performing second-line drug susceptibility testing make MODS a very interesting and attractive technique for LICs [42,43]. Moreover, it has recently been validated for DST in patients failing first-line TB treatment [44].…”
Section: Discussionmentioning
confidence: 99%
“…Being able to obtain the results of drug susceptibility testing within 8 days and the possibility of also performing second-line drug susceptibility testing make MODS a very interesting and attractive technique for LICs [42,43]. Moreover, it has recently been validated for DST in patients failing first-line TB treatment [44].…”
Section: Discussionmentioning
confidence: 99%