Validation of Milner's visco-elastic theory of sintering for the generation of porous polymers with finely tuned morphology

Lutzweiler, Gaëtan; Farago, Jean; Oliveira, E. L.; Jacomine, Léandro; Erverdi, Ozan; Vrana, Nihal Engin; Testouri, Aouatef; Schaaf, Pierre; Drenckhan, Wiebke

doi:10.1039/c9sm01991j

Cited by 3 publications

(4 citation statements)

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“…Additionally, the size of the interconnections can also be controlled through merging of particles packed in the initial template. Different strategies were followed as the addition of an adhesive [ 35 ], sintering [ 36 , 37 ], or chemical dissolution [ 38 ]. In all cases, the formation of a “neck” between adjacent particles leads to the formation of an interconnection in the porous material.…”

Section: Overview Of the Techniques Used For Fabrication Of Porousmentioning

confidence: 99%

“…Furthermore, the morphology of the final structure depends only on the morphology of the initial template, hence, a vast number of polymers can be used in this process. In one of our previous studies [ 37 ], porous scaffolds where interconnection sizes were controlled in a predictive manner using a new theoretical model of sintering were generated. Nearly identical sacrificial agents such as microspheres can lead to highly homogenous structures (see Figure 1 g) which is more likely to be used to investigate the influence of the scaffold’s structure on cell response [ 38 , 39 , 40 ].…”

Section: Overview Of the Techniques Used For Fabrication Of Porousmentioning

confidence: 99%

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The Overview of Porous, Bioactive Scaffolds as Instructive Biomaterials for Tissue Regeneration and Their Clinical Translation

2020

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Porous scaffolds have been employed for decades in the biomedical field where researchers have been seeking to produce an environment which could approach one of the extracellular matrixes supporting cells in natural tissues. Such three-dimensional systems offer many degrees of freedom to modulate cell activity, ranging from the chemistry of the structure and the architectural properties such as the porosity, the pore, and interconnection size. All these features can be exploited synergistically to tailor the cell–material interactions, and further, the tissue growth within the voids of the scaffold. Herein, an overview of the materials employed to generate porous scaffolds as well as the various techniques that are used to process them is supplied. Furthermore, scaffold parameters which modulate cell behavior are identified under distinct aspects: the architecture of inert scaffolds (i.e., pore and interconnection size, porosity, mechanical properties, etc.) alone on cell functions followed by comparison with bioactive scaffolds to grasp the most relevant features driving tissue regeneration. Finally, in vivo outcomes are highlighted comparing the accordance between in vitro and in vivo results in order to tackle the future translational challenges in tissue repair and regeneration.

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Section: Overview Of the Techniques Used For Fabrication Of Porousmentioning

confidence: 99%

Section: Overview Of the Techniques Used For Fabrication Of Porousmentioning

confidence: 99%

The Overview of Porous, Bioactive Scaffolds as Instructive Biomaterials for Tissue Regeneration and Their Clinical Translation

2020

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“…The mixing was achieved using an Ultra-Turrax ® (IKA, T25) at 20 krpm for 2 min. Scaffolds were prepared following the sphere templating method from our previous papers [19,21]. The obtained scaffolds had an average pore diameter of 133 ± 16 µm and interconnections between pores were 60 ± 12 µm in diameter.…”

Section: Pu Scaffold and Bsa Hydrogel Formationmentioning

confidence: 99%

Improving the colonization and functions of Wharton’s Jelly-derived mesenchymal stem cells by a synergetic combination of porous polyurethane scaffold with an albumin-derived hydrogel

Lutzweiler

Barthès²,

Charles³

et al. 2020

Biomed. Mater.

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The development of neo-tissues assisted by artificial scaffolds is continually progressing, but the reproduction of the extracellular environment surrounding cells is quite complex. While synthetic scaffolds can support cell growth, they lack biochemical cues that can prompt cell proliferation or differentiation. In this study, Wharton’s Jelly-derived mesenchymal stem cells are seeded on a polyurethane (PU) scaffold combined with a hydrogel based on bovine serum albumin (BSA). BSA hydrogel is obtained through thermal treatment. While such treatment leads to partial unfolding of the protein, we show that the extent of denaturation is small enough to maintain its bioactivity, such as protein binding. Therefore, BSA provides a suitable playground for cells inside the scaffold, allowing higher spreading, proliferation and matrix secretions. Furthermore, the poor mechanical properties of the hydrogel are compensated for by the porous PU scaffold, whose architecture is well controlled. We show that even though PU by itself can allow cell adhesion and protein secretion, cell proliferation is 3.5 times higher in the PU + BSA scaffolds as compared to pure PU after 21 d, along with the non-collagenous protein secretions (389 versus 134 μmmg −1). Conversely, the secretion of sulphated glycosaminoglycans is 12.3-fold higher in the scaffold made solely of PU. Thereby, we propose a simple approach to generating a hybrid material composed of a combination of PU and BSA hydrogel as a promising scaffold for tissue regeneration.

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“…Based on the abovementioned models, 8,9,11 viscoelastic effects of the coalescing system have been also taken into consideration. [12][13][14][15][16] Several computationally demanding formulations for free surface determination, using the finite element, boundary integral and volume of fluid methods have also been proposed. [17][18][19][20][21][22][23][24][25][26][27] Experimental measurements have been carried out involving polymeric particles.…”

Section: Introductionmentioning

confidence: 99%

Viscous coalescence of unequally sized spherical and cylindrical doublets

et al. 2022

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Validation of Milner's visco-elastic theory of sintering for the generation of porous polymers with finely tuned morphology

Abstract: The sintering of paraffin spheres is shown to be well described by Milner's visco-elastic model, providing a predictive tool for the generation of microporous polymers with controlled morphology via sphere templating.

Cited by 3 publications

References 48 publications

The Overview of Porous, Bioactive Scaffolds as Instructive Biomaterials for Tissue Regeneration and Their Clinical Translation

The Overview of Porous, Bioactive Scaffolds as Instructive Biomaterials for Tissue Regeneration and Their Clinical Translation

Improving the colonization and functions of Wharton’s Jelly-derived mesenchymal stem cells by a synergetic combination of porous polyurethane scaffold with an albumin-derived hydrogel

Viscous coalescence of unequally sized spherical and cylindrical doublets

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