Validation of Numerically Simulated Tissue Temperatures During Transcutaneous Recharge of Neurostimulation Systems

Abraham, John; Plourde, Brian D.

doi:10.1111/ner.12331

Cited by 6 publications

(4 citation statements)

References 53 publications

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“…Both the tissue temperature results and the thermal damage metrics strongly support the total absence of tissue injury when time-varying preprogrammed protocols are used in the recharging of neuromodulation implant-encased batteries. The methodology carried out here has been validated in multiple settings including animal model experiments [28]. That work, and other work that is currently in submission have used lamb and pig surrogates in experimentation.…”

Section: Discussionmentioning

confidence: 99%

Modulated-Power Implantable Neuromodulation Devices and Their Impact on Surrounding Tissue Temperatures

Stark¹,

Romero²,

Gorman³

et al. 2016

JBiSE

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This project was intended to determine whether the preprogrammed time-varying recharge protocol for a battery incased in a neuromodulation implant can give rise to tissue temperatures that surpass a safe level or are otherwise benign. The study included the development of a highly accurate model of all the thermal processes that are activated by the recharging of the battery contained within the neuromodulation implant. The model was implemented by numerical simulations performed for several realistic operating conditions. The computed spatial and temporal tissue temperature distributions were employed to estimate possible tissue damage by making use of two independent methodologies. Independent calorimeter-based experiments were performed to provide validation for the calculated rates of heat generation in the coils of the implant. Spatial and temporal tissue temperature distributions extracted from the numerical simulations revealed the thermal effects associated with several realistic operating protocols. None of the operating protocols gave rise to temperatures above 42˚C. Numerical values of thermal tissue damage metrics were determined and compared with accepted values which correspond to the absence and the presence of tissue damage. The experimentally determined rate of heat generation in the implant coils validated that from electrical measurements to within 2%. Both the tissue temperature results and the thermal damage metrics found no evidence of tissue injury when time-varying preprogrammed protocols are used in the recharging of neuromodulation implant-encased batteries.

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Section: Discussionmentioning

confidence: 99%

Modulated-Power Implantable Neuromodulation Devices and Their Impact on Surrounding Tissue Temperatures

Stark¹,

Romero²,

Gorman³

et al. 2016

JBiSE

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“…The equation assumes that the heat convection rate due to blood flow is proportional to the temperature difference between the tissue and the body core. Equation (9) has been verified in several studies [45], [46]. We derived the modified Pennes bioheat equation,…”

Section: E Biological Tissuementioning

confidence: 73%

Epileptic Seizure Suppression by Focal Brain Cooling With Recirculating Coolant Cooling System: Modeling and Simulation

Hata

Fujiwara

Inoue

et al. 2019

IEEE Trans. Neural Syst. Rehabil. Eng.

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A focal brain cooling system for treatment of refractory epilepsy that is implantable and wearable may permit patients with this condition to lead normal daily lives. We have developed such a system for cooling of the epileptic focus by delivery of cold saline to a cooling device that is implanted cranially. The outflow is pumped for circulation and cooled by a Peltier device. Here, we describe the design of the system and evaluate its feasibility by simulation. Mathematical models were constructed based on equations of fluid dynamics and data from a cat model. Computational fluid dynamics simulations gave the following results: 1) a cooling device with a complex channel structure gives a more uniform temperature in the brain; 2) a cooling period of <10 min is required to reach an average temperature of 25.0 • C at 2 mm below the brain surface, which is the target temperature for seizure suppression. This time is short enough for cooling of the brain before seizure onset after seizure prediction by an intracranial electroencephalogrambased algorithm; and 3) battery charging would be required once every several days for most patients. These results suggest that the focal brain cooling system may be clinically applicable.

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“…The results which were found were similar to the results using the baseline perfusion. Furthermore, prior work has also investigated this issue and found that large changes to perfusion are required for appreciable differences in the ultimate results. More details related to the incorporation of perfusion into the numerical model will be provided in discussion of Equation , later in this manuscript.…”

Section: The Numerical Modelmentioning

confidence: 99%

“… and that heating rate was used to calculate temperatures in multiple generations of devices and the surrounding tissue temperature . The effect of antenna‐implant alignment has also been studied in the scientific literature and comparisons of numerical predictions with animal model experiments has been completed .…”

Section: Introductionmentioning

confidence: 99%

Transcutaneous Recharge: A Comparison of Numerical Simulation to In Vivo Experiments

Plourde

Vallez

Nelson-Cheeseman

et al. 2017

Neuromodulation: Technology at the Neural Interface

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Validation of Numerically Simulated Tissue Temperatures During Transcutaneous Recharge of Neurostimulation Systems

Cited by 6 publications

References 53 publications

Modulated-Power Implantable Neuromodulation Devices and Their Impact on Surrounding Tissue Temperatures

Modulated-Power Implantable Neuromodulation Devices and Their Impact on Surrounding Tissue Temperatures

Epileptic Seizure Suppression by Focal Brain Cooling With Recirculating Coolant Cooling System: Modeling and Simulation

Transcutaneous Recharge: A Comparison of Numerical Simulation to In Vivo Experiments

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