Validation of reaction time as a measure of cognitive function and quality of life in healthy subjects and patients

Jakobsen, Lene H.; Sorensen, Janice; Rask, Ingeborg K.; Jensen, Bente; Kondrup, Jens

doi:10.1016/j.nut.2010.08.003

Cited by 66 publications

(49 citation statements)

References 27 publications

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“…It has been shown that reaction time is related with cognitive functions in healthy controls and with cognitive functions and quality of life in malnutrition patients 44 . Kelly et al 45 examined the effects of cannabis on driving performance and found impaired reaction time in chronic cannabis users.…”

Section: Discussionmentioning

confidence: 99%

The Changes of the Cognitive and Psychomotor Functions in the Chronic Cannabis Users after a Month of Remission

Umut

Atagün

Evren

et al. 2016

Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychophar

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ABS TRACT:The changes of the cognitive and psychomotor functions in the chronic cannabis users after a month of remission Objective: In our study, it is aimed to investigate impacts of cannabis use on information processing and psychomotor functions and to examine changes in the cognitive functions at the end of abstinence over a month. Method:The study was initiated with 34 volunteer participants using cannabis at least over two years, directed by a forensic unit. 34 persons were assessed at admission and were planned to assess after a month of remission. As 14 participants discontinued the study 20 participants only were assessed again at the end Results: There was no statistically significant difference between participants continue to the treatment and those discontinue in terms of sociodemographic and clinical characteristics. The participants discontinue were using more daily cannabis dose. The auditory reaction time of the group continue to the treatment decreased statistically significantly after a month whereas there was no statistically significant difference in the visual reaction time. The scores of the AMIPB-A and AMIPB-B were detected statistically higher after a month compared to admission. The score of the dominant hand FTT after a month was detected statistically higher than that in admission whereas there was no statistically significant difference in the non-dominant hand score. Conclusion:Improvements in scores of AMIP-A, AMIP-B, FTT and auditory reaction time after one month of quitting cannabis suggest that cannabis use may impair cognitive functions such as information processing, reaction time and motor functions. We suggest that future studies to assess cognitive functions after either a shorter (i.e. 1 week) or a longer (i.e. 2 months) period of cannabis abstinence in larger samples may provide further useful data about the relationship between cannabis use and cognitive functions.

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Section: Discussionmentioning

confidence: 99%

The Changes of the Cognitive and Psychomotor Functions in the Chronic Cannabis Users after a Month of Remission

Umut

Atagün

Evren

et al. 2016

Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychophar

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“…Mounting evidence supports is use: we and others have shown that more than half of liver patients with no other cause of brain involvement have an abnormal test result; that there is no learning or tiring effect; that the test result is not age or gender dependent; not related to educational or social status; and that it is not disturbed by sleep deprivation (Elsass 1986;Jakobsen et al 2010;Lauridsen et al 2014;Lauridsen et al 2012;Lauridsen et al 2013;Elsass et al 1985). However, the CRT test has not been systematically conducted in parallel with the PSE test and consequently has not been compared with a test of other cognitive domains.…”

Section: Introductionmentioning

confidence: 97%

“…In Denmark, health professionals have many years of experience in using the computerized psychometric test, the Continuous Reaction Time test (CRT) (Jakobsen et al 2010), for diagnosing and grading MHE. Mounting evidence supports is use: we and others have shown that more than half of liver patients with no other cause of brain involvement have an abnormal test result; that there is no learning or tiring effect; that the test result is not age or gender dependent; not related to educational or social status; and that it is not disturbed by sleep deprivation (Elsass 1986;Jakobsen et al 2010;Lauridsen et al 2014;Lauridsen et al 2012;Lauridsen et al 2013;Elsass et al 1985).…”

Section: Introductionmentioning

confidence: 99%

Minimal hepatic encephalopathy characterized by parallel use of the continuous reaction time and portosystemic encephalopathy tests

2015

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Minimal hepatic encephalopathy (MHE) is a frequent complication to liver cirrhosis that causes poor quality of life, a great burden to caregivers, and can be treated. For diagnosis and grading the international guidelines recommend the use of psychometric tests of different modalities (computer based vs. paper and pencil). To compare results of the Continuous Reaction time (CRT) and the Portosystemic Encephalopathy (PSE) tests in a large unselected cohort of cirrhosis patients without clinically detectable brain impairment and to clinically characterize the patients according to their test results. The CRT method is a 10-minute computerized test of a patient's motor reaction time stability (CRTindex) to 150 auditory stimuli. The PSE test is a 20-minute paper-pencil test evaluating psychomotor speed. Both tests were performed at the same occasion in 129 patients. Both tests were normal in only 36% (n = 46) of the patients and this group had the best quality of life, a normal CRP, a low risk of subsequent overt HE, and a low short term mortality. Either the CRT or the PSE test was abnormal in a total of 64% of the patients (n = 83), the CRT in 53% (n = 69) and the PSE in 34% (n = 44). All these patients had a poorer quality of life, low-grade CRP elevation, moderate risk for subsequent overt HE, and a higher than 20% short term mortality. Both tests were abnormal in 23% (n = 30) of the patients and this group had more advanced cirrhosis and a 40 % short-term mortality. One of the tests was abnormal in the majority of the patients but concordant in only 60%. Most cirrhosis patients seem to have impairments of different cognitive domains and more domains with advancing disease. Two abnormal tests identified patients with an increased risk of overt HE and death.

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“…15,16 Reaction time has been correlated to cognitive function in both healthy and injured people, and reaction time was found to be inversely proportional to the quality of fine motor control. 17 In general, we should expect multiple reaction time measurements to be a reasonable parameter providing an objective measure for ability and training status, provided that the many variables discussed above are accounted for. For a generally ''normal'' population of people, using only a sight stimulus, reaction times measured by computer experiments have been reported as 268 milliseconds.…”

Section: Reaction Timementioning

confidence: 99%

Objective Screening Parameters for Training-Rehabilitation of Sports Teams

Karasch

Brown

Smith

et al. 2015

Journal of Clinical Engineering

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Validation of reaction time as a measure of cognitive function and quality of life in healthy subjects and patients

Cited by 66 publications

References 27 publications

The Changes of the Cognitive and Psychomotor Functions in the Chronic Cannabis Users after a Month of Remission

The Changes of the Cognitive and Psychomotor Functions in the Chronic Cannabis Users after a Month of Remission

Minimal hepatic encephalopathy characterized by parallel use of the continuous reaction time and portosystemic encephalopathy tests

Objective Screening Parameters for Training-Rehabilitation of Sports Teams

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