Validation of the Chinese Version of Addenbrooke's Cognitive Examination-Revised for Screening Mild Alzheimer's Disease and Mild Cognitive Impairment

Fang, Rong; Wang, Gang; Huang, Yue; Zhuang, Jun-Peng; Tang, Huidong; Wang, Ying; Deng, Yulei; Xu, Wei; Chen, Shengdi; Ren, Rong

doi:10.1159/000353541

Cited by 46 publications

(59 citation statements)

References 67 publications

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“…However, the cutoff point was lower in a UK memory clinic with patients aged 75-85 years (81/100) [23], and even lower in our previous study in Spain (65/100) in a population with a mean age of 78 years and a mean number of years of education of 7.4 as well as different types of dementia [4]. Similar discrepancies were observed in the previous versions of the ACE [24,25,26]. In this regard, the implementation of the current norms to the sample of healthy controls and patients with mild dementia of different types used in our previous study of validation of the ACE-III [4] demonstrated an improvement of the accuracy for the discrimination between healthy and cognitively impaired individuals.…”

Section: Discussionsupporting

confidence: 60%

Normative Data for the Spanish Version of the Addenbrooke's Cognitive Examination III

Matías‐Guiu

Fernández-Bobadilla

Fernández-Oliveira³

et al. 2016

Dement Geriatr Cogn Disord

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Background: Addenbrooke's Cognitive Examination III (ACE-III) is a cognitive test that has been validated for the diagnosis of cognitive disorders. The aim of this study was to provide normative data for the ACE-III for age, education and gender. Methods: The Spanish version of the ACE-III was administered to a group of 273 healthy subjects in a multicenter study in Spain. Correlation and determination coefficients for age, education and gender were estimated. The overlapping interval strategy and linear regression analyses were used to provide adjusted norms for demographic factors and to explore the potential influence of these factors in the performance of the test. Results: Age and education correlated significantly with the total score and with all the domains. Gender correlated only with the domains of attention and visuospatial skills. Norms for the total score and for cognitive domains (attention, memory, fluency, language, and visuospatial skills) are provided. Conclusion: This study confirms the influence of demographic factors (especially age and education) on the performance in the ACE-III and provides normative data for the Spanish version of the ACE-III.

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Section: Discussionsupporting

confidence: 60%

Normative Data for the Spanish Version of the Addenbrooke's Cognitive Examination III

Matías‐Guiu

Fernández-Bobadilla

Fernández-Oliveira³

et al. 2016

Dement Geriatr Cogn Disord

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“…We followed the criteria proposed by Petersen [13, 28, 29] (significant impairment of the patient and/or caregiver’s report, objective evidence of memory decline compared to equivalent controls for age, sex, and years of schooling; Clinical Dementia Rating Scale [CDR] score equal to 0.5 and preservation of activities of daily living).…”

Section: Methods and Subjectsmentioning

confidence: 99%

“…This is an important limitation if we consider that previous studies showed that the annual conversion rate from MCI to Alzheimer disease (AD) was 10–15%, and approximately 50% of MCI patients will convert to AD within 4 years [6]. Therefore, MCI is considered to be a transition phase from normal aging to AD, and its precise detection allows to initiate early treatment [13]. …”

Section: Introductionmentioning

confidence: 99%

“…There is currently evidence that Addenbrooke’s Cognitive Examination Revised (ACE-R) has a higher diagnostic sensitivity for the detection of MCI compared to MMSE [13-15]. In addition, ACE-R has been shown to have a greater diagnostic sensitivity and specificity than MMSE in diseases such as Parkinson disease (PD) [16, 17], AD [18, 19], behavioral variant frontotemporal dementia (bvFTD) [19, 20], vascular dementia [18], and dementia with Lewy bodies [19].…”

Section: Introductionmentioning

confidence: 99%

“…ACE-R has been translated into Portuguese [24], German [18], Greek [25], Korean [26], Japanese [14], Chinese [13], and Spanish [20]. In the Americas, it has been validated in Colombia [27], Argentina [20], Brazil [24], and Chile [15].…”

Section: Introductionmentioning

confidence: 99%

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Validation of the Cuban Version of Addenbrooke’s Cognitive Examination-Revised for<b></b> Screening<b></b> Mild Cognitive Impairment

Broche-Pérez¹,

López-Pujol²

2017

Dement Geriatr Cogn Disord

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Background/Aims: The diagnostic accuracy of the Cuban version of the revised Addenbrooke’s Cognitive Examination (ACE-R) in identifying mild cognitive impairment (MCI) in comparison with the Mini-Mental State Examination (MMSE) was assessed. Methods: The Cuban ACE-R was administered to a group of 129 elderly subjects (92 cognitively healthy and 37 subjects with MCI). The t tests for independent samples were used to compare scores of different psychometric scales between groups, and effect sizes (Cohen’s d) were calculated. Cronbach’s coefficient α was used to evaluate the reliability of psychometric scales. The validity of ACE-R to screen for MCI was assessed by receiver operating characteristic (ROC) curves. Results: The Cuban ACE-R had reliable internal consistency (Cronbach’s coefficient α = 0. 879). The optimal cut-off score for ACE-R for detecting MCI was 84/85. The sensitivity and specificity of ACE-R to screen for MCI was superior to those of MMSE. The area under the ROC curve of the Cuban ACE-R was much larger than that of MMSE (0.93 and 0.63) for detecting MCI. Conclusion: The Cuban ACE-R is a valid screening tool for detecting cognitive impairment. It is more sensitive and accurate in screening for MCI than MMSE.

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Cognitive Tests to Detect Dementia

et al. 2015

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IMPORTANCE Dementia is a global public health problem. The Mini-Mental State Examination (MMSE) is a proprietary instrument for detecting dementia, but many other tests are also available.OBJECTIVE To evaluate the diagnostic performance of all cognitive tests for the detection of dementia.DATA SOURCES Literature searches were performed on the list of dementia screening tests in MEDLINE, EMBASE, and PsychoINFO from the earliest available dates stated in the individual databases until September 1, 2014. Because Google Scholar searches literature with a combined ranking algorithm on citation counts and keywords in each article, our literature search was extended to Google Scholar with individual test names and dementia screening as a supplementary search.STUDY SELECTION Studies were eligible if participants were interviewed face to face with respective screening tests, and findings were compared with criterion standard diagnostic criteria for dementia. Bivariate random-effects models were used, and the area under the summary receiver-operating characteristic curve was used to present the overall performance.MAIN OUTCOMES AND MEASURES Sensitivity, specificity, and positive and negative likelihood ratios were the main outcomes.RESULTS Eleven screening tests were identified among 149 studies with more than 49 000 participants. Most studies used the MMSE (n = 102) and included 10 263 patients with dementia. The combined sensitivity and specificity for detection of dementia were 0.81 (95% CI, 0.78-0.84) and 0.89 (95% CI, 0.87-0.91), respectively. Among the other 10 tests, the Mini-Cog test and Addenbrooke's Cognitive Examination-Revised (ACE-R) had the best diagnostic performances, which were comparable to that of the MMSE (Mini-Cog, 0.91 sensitivity and 0.86 specificity; ACE-R, 0.92 sensitivity and 0.89 specificity). Subgroup analysis revealed that only the Montreal Cognitive Assessment had comparable performance to the MMSE on detection of mild cognitive impairment with 0.89 sensitivity and 0.75 specificity. CONCLUSIONS AND RELEVANCEBesides the MMSE, there are many other tests with comparable diagnostic performance for detecting dementia. The Mini-Cog test and the ACE-R are the best alternative screening tests for dementia, and the Montreal Cognitive Assessment is the best alternative for mild cognitive impairment.

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Validation of the Chinese Version of Addenbrooke's Cognitive Examination-Revised for Screening Mild Alzheimer's Disease and Mild Cognitive Impairment

Cited by 46 publications

References 67 publications

Normative Data for the Spanish Version of the Addenbrooke's Cognitive Examination III

Normative Data for the Spanish Version of the Addenbrooke's Cognitive Examination III

Validation of the Cuban Version of Addenbrooke’s Cognitive Examination-Revised for<b></b> Screening<b></b> Mild Cognitive Impairment

Cognitive Tests to Detect Dementia

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