Validation of the Chinese Version of the Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease

Xu, Tian; Cao, Lanxiao; Long, Wenying; Zhao, Guohua

doi:10.3389/fneur.2021.731552

Cited by 4 publications

(3 citation statements)

References 29 publications

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“…It's worth noting that even within the same country, there are disparities in the incidence rates of ICD among different regions. In economically more developed southern regions, the incidence rate of ICD appears to be lower, such as 4.15% in Shanghai (Wang et al, 2016), 7% in Hong Kong (Auyeung et al, 2011), and 9.15% in Zhejiang (Xu et al, 2021). This might be attributed to fewer specialized doctors for PD in northern China, a delay in early diagnosis and treatment, and a lower rate of early medical consultation among patients.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of risk factors for impulse control disorder in Parkinson’s disease in northern China

Ren,

Qi,

Liu

et al. 2023

Front. Aging Neurosci.

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IntroductionImpulse control disorder (ICD) is a common non-motor symptom of Parkinson’s disease (PD), but its risk factors are still controversial. This study aimed to determine the prevalence of ICD in northern China and analyze the risk factors associated with ICD, multiple ICDs, and four subtypes.MethodsA total of 285 PD patients were enrolled in this study. Each patient was screened using the Questionnaire for Impulse and Compulsive Control Disorders (QUIP). Stepwise regression analysis was performed to identify independent risk factors, and a prediction model was developed.ResultsThe prevalence of ICD in the study population was 11.6%. Stepwise regression analysis showed that ICD was associated with disease duration, motor symptoms, dyskinesia, depression, REM sleep behavior disorder (RBD) and cognitive decline; multiple ICDs were related to coffee history, motor symptoms, dyskinesia, depression, apathy and RBD. The prediction model demonstrated good performance with AUC values of 0.93, 0.88, and 0.66 on the balanced train set, balanced test set, and the original imbalanced data set, respectively.ConclusionThe risk factors for PD-ICD are complex and influenced by regional economic and cultural backgrounds. Clarifying these factors and developing predictive models can help to delay or even prevent the development of ICD through early screening and intervention.

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Section: Discussionmentioning

confidence: 99%

Evaluation of risk factors for impulse control disorder in Parkinson’s disease in northern China

Ren,

Qi,

Liu

et al. 2023

Front. Aging Neurosci.

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“…Previous studies have shown a wide variation in the prevalence of DDS, ranging from 2.2% to 10.4% [5,6,8,18,19]. Accumulating evidence suggests that DDS in PD patients is the result of a history of dopaminergic drug use, genetic predisposition, history of psychiatric disorders, and impulsive personality [9,12].…”

Section: Discussionmentioning

confidence: 99%

“…Even with severe drug-induced dyskinesias, they are still unwilling to stop taking the drugs, which seriously affects their quality of life [4]. Previous studies have shown that the incidence of DDS in PD patients is approximately 2.2-4% [5][6][7][8][9] and may be related to dysfunction of the dopaminergic reward system [10]. At present, there are few studies on DDS, and the risk factors for DDS in patients with PD are not clear.…”

Section: Introductionmentioning

confidence: 99%

Predictors of Dopamine Dysregulation Syndrome in Patients with Early Parkinson's Disease

Liang¹,

Li²,

Ma³

et al. 2022

Preprint

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Background: Dopamine dysregulationsyndrome (DDS) is a complication of Parkinson's disease (PD) that seriously affects the quality of life of PD patients. Currently, the risk factors for DDS are unknown, and it is critical to identify them in the early stages of PD. Objective: To explore the incidence of and risk factors for DDS in patients with early PD. Methods: A retrospective cohort study was conducted on the general data, clinical features and imaging data of patients with early PD in the PPMI database. Multivariate Cox regression analysis was performed to analyze the risk factors for the development of DDS in patients with early PD, and Kaplan‒Meier curves examined the frequency and predictors of incident DDS symptoms. Results: At baseline, 2.2% (n=6) of patients with early PD developed DDS, and the cumulative incidence rates of DDS during the 5-year follow-up period were 2.8%, 6.4%, 10.8%, 15.5% and 18.7%, respectively. In the multivariate Cox regression model controlling for age, sex and drug use, hypersexuality (HR=3.088; 95% CI: 1.416~6.732; P=0.005), compulsive eating (HR=3.299; 95% CI: 1.665~6.534; P=0.001), compulsive shopping (HR=3.899; 95% CI: 1.769~8.593; P=0.001), anxiety(HR=4.018; 95% CI: 2.136~7.599; P<0.01) and lower Hoehn-Yahr (H-Y) stage (HR=0.278; 95% CI: 0.152~0.509; P<0.01) were independent risk factors for DDS in patients with early PD. Dopamine transporter (DAT) uptake in PD patients with DDS was lower after follow-up than at baseline. Conclusion: Early PD patients with a hypersexuality, compulsive eating, compulsive shopping, anxiety and lower H-Y stage were at increased risk for DDS. The occurrence of DDS may be related to the decrease in the average DAT uptake of the caudate and putamen.

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Predictors of dopamine dysregulation syndrome in patients with early Parkinson’s disease

Liang

et al. 2023

Neurol Sci

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Background Dopamine dysregulation syndrome (DDS) is a complication of Parkinson’s disease (PD) that seriously affects the quality of life of PD patients. Currently, the risk factors for DDS are poorly known, and it is critical to identify them in the early stages of PD. Objective To explore the incidence of and risk factors for DDS in patients with early PD. Methods A retrospective cohort study was conducted on the general data, clinical features, and imaging data of patients with early PD in the PPMI database. Multivariate Cox regression analysis was performed to analyze the risk factors for the development of DDS in patients with early PD, and Kaplan‒Meier curves examined the frequency and predictors of incident DDS symptoms. Results At baseline, 2.2% (n = 6) of patients with early PD developed DDS, and the cumulative incidence rates of DDS during the 5-year follow-up period were 2.8%, 6.4%, 10.8%, 15.5%, and 18.7%, respectively. In the multivariate Cox regression model controlling for age, sex, and drug use, hypersexuality (HR = 3.088; 95% CI: 1.416~6.732; P = 0.005), compulsive eating (HR = 3.299; 95% CI: 1.665~6.534; P = 0.001), compulsive shopping (HR = 3.899; 95% CI: 1.769~8.593; P = 0.001), anxiety (HR = 4.018; 95% CI: 2.136~7.599; P < 0.01), and lower Hoehn-Yahr (H-Y) stage (HR = 0.278; 95% CI: 0.152~0.509; P < 0.01) were independent risk factors for DDS in patients with early PD. PD patients with DDS had lower DAT uptake values than those patients without DDS. Conclusion Early PD patients with hypersexuality, compulsive eating, compulsive shopping, anxiety, and lower H-Y stage were at increased risk for DDS. The occurrence of DDS may be related to the decrease in the average DAT uptake of the caudate and putamen.

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Validation of the Chinese Version of the Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease

Cited by 4 publications

References 29 publications

Evaluation of risk factors for impulse control disorder in Parkinson’s disease in northern China

Evaluation of risk factors for impulse control disorder in Parkinson’s disease in northern China

Predictors of Dopamine Dysregulation Syndrome in Patients with Early Parkinson's Disease

Predictors of dopamine dysregulation syndrome in patients with early Parkinson’s disease

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