Validation of the Freezing of Gait Questionnaire in patients with Parkinson’s disease treated with deep brain stimulation

Gál, Ota; Poláková, Kamila; Brožová, Hana; Bezdíček, Ondřej; Hoskovcová, Martina; Jech, Robert; Růžička, Evžen

doi:10.1007/s10072-019-04209-3

Cited by 5 publications

(10 citation statements)

References 37 publications

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“…In the reliability study, the index of internal consistency, the Cα, for the FOGQ-CH was 0.823, a value which is similar to that found with other translated versions of the FOGQ (Spanish version: Cα = 0.81, German version: Cα = 0.83, and Brazilian version: Cα = 0.86) ( 7 , 9 , 10 ). However, the original English version (Cα = 0.94), the Swedish version (Cα = 0.95) and the Czech version (Cα = 0.91) had values for internal consistency that were very high ( 4 , 5 , 11 ). Nevertheless, all translated versions met the range requirement of 0.7–0.95, which meant that the FOGQ-CH has strong internal consistency ( 23 ).…”

Section: Discussionmentioning

confidence: 97%

“…Being older, falls, hallucinations, having anxiety, living in the countryside, having an akinetic-rigid style, and onset of lower limbs may be the predictors of FOG in Chinese patients ( 29 , 30 ). The FOGQ has been found to be a reliable and valid measurement tool when used to assess FOG in other language versions ( 4 , 5 , 8 – 11 ). The questionnaire had no floor or ceiling effects, and it had a high internal consistency, good inter and intra-rater reliability, good content, and convergent validity.…”

Section: Discussionmentioning

confidence: 99%

“…It has six questions and can easily be administered in clinics. To date, the FOGQ has been translated to different languages, including Swedish, Italian, Turkish, Spanish, Brazilian, German, and Czech ( 4 , 6 – 11 ), and these versions have shown good validity and reliability. China has the largest population with PD globally, and it is estimated that the number of patients with PD in China will reach half of all patients with PD in the world by 2030 ( 12 ).…”

Section: Introductionmentioning

confidence: 99%

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Translation, Cultural Adaptation, and Reliability and Validity Testing of a Chinese Version of the Freezing of Gait Questionnaire (FOGQ-CH)

et al. 2021

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Freezing of gait is a disabling symptom with a complex episodic nature that is frequently experienced by people with Parkinson's disease (PD). Although China has the largest population with PD in the world, no Chinese version of the freezing of gait questionnaire (FOGQ), the instrument that has been most widely used to assess FOG, has yet been developed. This study aimed to translate and adapt the original version of FOGQ to create a Chinese version, the FOGQ-CH, then assess its reliability, calculate the Minimal Detectable Change (MDC) and investigate its validity. The forward-backwards translation model was adopted, and cultural adaptation included expert review and pretesting. For the reliability study, 31 Chinese native speaking patients with PD were assessed two times in a 7–10 days interval. Internal consistency and test-retest reliability of the FOGQ-CH were measured by Cronbach's alpha (Cα) and the Intraclass Correlation Coefficient (ICC). For the validity study, 34 native speakers of Chinese with PD were included. To explore the convergent validity, relationships between the FOGQ-CH and the Unified Parkinson's Disease Rating Scale Part II (UPDRS II) and Part III (UPDRS III), Timed Up and Go Test (TUGT), Timed Up and Go Test in cognitive task (TUGT-Cog), walking speed (10 MWT speed), and step length (10 MWT step length) in a 10-m Walk Test were tested. To explore predictive validity, the number of falls followed up for 6 months were assessed. The area under the ROC curve (AUC) was employed to test the capacity of FOGQ-CH to discriminate those with falls. From the reliability study, Cα = 0.823, ICC = 0.786. The MDC0.90 = 4.538. From the validity study, the FOGQ-CH showed moderate correlations with UPDRS II (rho = 0.560, p = 0.001), UPDRS III (rho = 0.451, p = 0.007), TUGT (rho = 0.556, p = 0.007), TUGT-Cog (rho = 0.557, p = 0.001), 10MWT-speed (rho = −0.478, p = 0.004), 10MWT-step length (rho = −0.419, p = 0.014), and the number of falls followed up for 6 months (rho = 0.356, p = 0.045). The AUC = 0.777 (p = 0.036) for predicting whether the participants will have multiple falls (two or more) in the following 6 months. The FOGQ-CH showed good reliability and validity for assessing Chinese native speaking patients with PD. In addition, the FOGQ-CH showed good efficacy for predicting multiple falls in the following 6 months.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Translation, Cultural Adaptation, and Reliability and Validity Testing of a Chinese Version of the Freezing of Gait Questionnaire (FOGQ-CH)

et al. 2021

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“…(i) Subjective decision: according to item 3 of the Freezing of Gait Questionnaire (FOGQ) ( Giladi et al, 2000 ; Gal et al, 2020 ), patients were asked whether they felt their feet were stuck to the ground during starting, turning, or walking; (ii) subjective determination: confirmed by showing typical videos of a typical freezing gait episode to the patient and caregivers ( Nonnekes et al, 2017 ); (iii) Objective determination: freezing gait was induced by bi-directional 360° rapid turns, dual-tasking, and small rapid steps ( van Dijsseldonk et al, 2018 ; Mancini et al, 2019 ); (d) Hoehn-Yahr stage (H-Y stage) ( Hoehn and Yahr, 1967 ; Skorvanek et al, 2017 ): stage 2–4; (e) Mini-Mental State Examination (MMSE) ( Santana et al, 2016 ) ≥ 24 points; (f) PD medication stabilized for more than 2 weeks and no change in medication regimen during the study period; and (g) being available to cooperate in completing the rTMS treatment and symptom assessment. The study protocol was approved and supervised by the Affiliated Hospital of Xuzhou Medical University Ethics Committee (No.…”

Section: Methodsmentioning

confidence: 99%

Section: Participantsmentioning

confidence: 99%

High-frequency rTMS over bilateral primary motor cortex improves freezing of gait and emotion regulation in patients with Parkinson’s disease: a randomized controlled trial

Song,

Zhang,

et al. 2024

Front. Aging Neurosci.

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BackgroundFreezing of gait (FOG) is a common and disabling phenomenon in patients with Parkinson’s disease (PD), but effective treatment approach remains inconclusive. Dysfunctional emotional factors play a key role in FOG. Since primary motor cortex (M1) connects with prefrontal areas via the frontal longitudinal system, where are responsible for emotional regulation, we hypothesized M1 may be a potential neuromodulation target for FOG therapy. The purpose of this study is to explore whether high-frequency rTMS over bilateral M1 could relieve FOG and emotional dysregulation in patients with PD.MethodsThis study is a single-center, randomized double-blind clinical trial. Forty-eight patients with PD and FOG from the Affiliated Hospital of Xuzhou Medical University were randomly assigned to receive 10 sessions of either active (N = 24) or sham (N = 24) 10 Hz rTMS over the bilateral M1. Patients were evaluated at baseline (T0), after the last session of treatment (T1) and 30 days after the last session (T2). The primary outcomes were Freezing of Gait Questionnaire (FOGQ) scores, with Timed Up and Go Test (TUG) time, Standing-Start 180° Turn (SS-180) time, SS-180 steps, United Parkinson Disease Rating Scales (UPDRS) III, Hamilton Depression scale (HAMD)-24 and Hamilton Anxiety scale (HAMA)-14 as secondary outcomes.ResultsTwo patients in each group dropped out at T2 and no serious adverse events were reported by any subject. Two-way repeated ANOVAs revealed significant group × time interactions in FOGQ, TUG, SS-180 turn time, SS-180 turning steps, UPDRS III, HAMD-24 and HAMA-14. Post-hoc analyses showed that compared to T0, the active group exhibited remarkable improvements in FOGQ, TUG, SS-180 turn time, SS-180 turning steps, UPDRS III, HAMD-24 and HAMA-14 at T1 and T2. No significant improvement was found in the sham group. The Spearman correlation analysis revealed a significantly positive association between the changes in HAMD-24 and HAMA-14 scores and FOGQ scores at T1.ConclusionHigh-frequency rTMS over bilateral M1 can improve FOG and reduce depression and anxiety in patients with PD.

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The validation of a Japanese version of the New Freezing of Gait Questionnaire (NFOG-Q)

Taniguchi,

Marumoto,

Kajiyama

et al. 2024

Neurol Sci

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Objective This study aimed to develop a Japanese version of the New Freezing of Gait Questionnaire (NFOG-Q) and investigate its validity and reliability. Methods After translating the NFOG-Q according to a standardised protocol, 56 patients with Parkinson’s disease (PD) were administered it. Additionally, the MDS-UPDRS parts II and III, Hoehn and Yahr (H&Y) stage, and number of falls over 1 month were evaluated. Spearman’s correlation coefficients (rho) were used to determine construct validity, and Cronbach’s alpha (α) was used to examine reliability. Results The interquartile range of the NFOG-Q scores was 10.0–25.3 (range 0–29). The NFOG-Q scores were strongly correlated with the MDS-UPDRS part II, items 2.12 (walking and balance), 2.13 (freezing), 3.11 (freezing of gait), and 3.12 (postural stability) and the postural instability and gait difficulty score (rho = 0.515–0.669), but only moderately related to the MDS-UPDRS item 3.10 (gait), number of falls, disease duration, H&Y stage, and time of the Timed Up-and-Go test (rho = 0.319–0.434). No significant correlations were observed between age and the time of the 10-m walk test. The internal consistency was excellent (α = 0.96). Conclusions The Japanese version of the NFOG-Q is a valid and reliable tool for assessing the severity of freezing in patients with PD.

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Validation of the Freezing of Gait Questionnaire in patients with Parkinson’s disease treated with deep brain stimulation

Cited by 5 publications

References 37 publications

Translation, Cultural Adaptation, and Reliability and Validity Testing of a Chinese Version of the Freezing of Gait Questionnaire (FOGQ-CH)

Translation, Cultural Adaptation, and Reliability and Validity Testing of a Chinese Version of the Freezing of Gait Questionnaire (FOGQ-CH)

High-frequency rTMS over bilateral primary motor cortex improves freezing of gait and emotion regulation in patients with Parkinson’s disease: a randomized controlled trial

The validation of a Japanese version of the New Freezing of Gait Questionnaire (NFOG-Q)

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