Validation of the omega-3 fatty acid intake measured by a web-based food frequency questionnaire against omega-3 fatty acids in red blood cells in men with prostate cancer

Allaire, Janie; Moreel, Xavier; Mè, Labonté; Léger, Caroline; Caron, André; Julien, Pierre; Lamarche, Benoı̂t; Fradet, Vincent

doi:10.1038/ejcn.2015.7

Cited by 12 publications

(8 citation statements)

References 39 publications

(51 reference statements)

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“…Subsequently, Turcot et al 28 modified an existing 14-item FFQ for use in 137 participants (62% with hyperlipidaemia). They reported adjusted Spearman's correlations for ALA of 0.23 and 0.18 for total n3, with values for EPA and DHA of 0.29 and 0.41 respectively, which were consistent with the range of correlations found by Serra-Majem et al More recently Allaire et al 29 reported higher adjusted Spearman correlations of 0.59, 0.59 and 0.55 for EPA, DHA and LCn3, respectively (P o0.01) using a larger range of questions (136 questions with 40 sub-questions) in a sample of 60 men with prostate cancer. The results from the current study are similar to those of Allaire et al, as would be expected based on the greater number of questions used to identify food intakes related to CVD, as in the current study.…”

Section: Discussionsupporting

confidence: 81%

Comparison of fatty acid intakes assessed by a cardiovascular-specific food frequency questionnaire with red blood cell membrane fatty acids in hyperlipidaemic Australian adults: a validation study

et al. 2016

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Section: Discussionsupporting

confidence: 81%

Comparison of fatty acid intakes assessed by a cardiovascular-specific food frequency questionnaire with red blood cell membrane fatty acids in hyperlipidaemic Australian adults: a validation study

et al. 2016

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“…Previous FFQs have mainly focused on fatty fish intake, assumed to reflect marine n-3FA consumption better than total fish intake [23][24][25][26][27][28][29][30][31][32][33][34][35]. We hypothesized that a more meticulous approach using weighted response scales based on EPA and DHA content in fatty and lean fish, other seafoods and marine n-3FA supplements would provide a more precise estimation of marine n-3FA consumption.…”

Section: Discussionmentioning

confidence: 99%

Marine n-3 fatty acid consumption in a Norwegian renal transplant cohort: Comparison of a food frequency questionnaire with plasma phospholipid marine n-3 levels

et al. 2020

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Background High levels of plasma marine n-3 fatty acids (n-3FAs) are associated with improved patient and graft survival in renal transplant recipients (RTRs). The aim of this study was to evaluate the utility of a new food frequency questionnaire (FFQ) to estimate marine n-3FA consumption in future epidemiological research. Methods We developed an FFQ with a simple design of 10 questions to assess intake of marine sources of n-3FAs. RTRs included in the recent ORENTRA trial (n = 132) completed the study FFQ at the baseline visit eight weeks after engraftment and at the end of study visit one year post-transplant. We measured the reference biomarker plasma phospholipid (PL) marine n-3FA levels by gas chromatography at the same time points to evaluate association and degree of agreement between FFQ based marine n-3FA consumption estimates and the biomarker. Results The median plasma PL marine n-3FA level was 6.0 weight percentage (wt)% (interquartile range [IQR] 4.7 to 7.3) at baseline and 6.3 wt% (IQR 4.8 to 7.4) at end of study. Median FFQ based marine n-3FA consumption estimates were 22.8 g/month (IQR 13.0 to 34.0) at baseline and 20.3 g/month (IQR 14.5 to 32.3) at end of study. FFQ based marine n-3FA consumption estimates showed a moderate correlation with plasma PL marine n-3FA levels at baseline (Spearman’s correlation coefficient rs = 0.43, p<0.001) and a stronger correlation at end of study (rs = 0.62, p<0.001). Bland Altman plots showed a reasonable degree of agreement between the two methods at both time points. Conclusions Marine n-3FA consumption estimates based on the FFQ showed a moderate correlation with the reference biomarker plasma PL marine n-3FA levels. The FFQ might be useful in epidemiological studies where resources are limited.

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“…This web-FFQ contains standardized photographs of most food items, to help the participant quantify portion sizes, and was developed and validated specifically for Quebec citizens, who constitute the totality of our study population [33]. We also previously validated ability of this web-FFQ to assess ω3 intake specifically in PCa patients [34].…”

Section: Methodsmentioning

confidence: 99%

Omega-3 Fatty Acids Survey in Men under Active Surveillance for Prostate Cancer: from Intake to Prostate Tissue Level

et al. 2019

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Dietary omega-3 fatty acids (ω3), particularly long-chain ω3 (LCω3), have protective effects against prostate cancer (PCa) in experimental studies. Observational studies are conflicting, possibly because of the biomarker used. This study aimed at evaluating associations between grade reclassification and ω3 levels assessed in prostatic tissue, red blood cells (RBC), and diet. We conducted a validation cross-sectional study nested within a phase II clinical trial. We identified 157 men diagnosed with low-risk PCa who underwent a first active surveillance repeat prostate biopsy session. Fatty acid (FA) intake was assessed using a food frequency questionnaire and their levels measured in prostate tissue and RBC. Associations were evaluated using logistic regression. At first repeat biopsy session, 39 (25%) men had high-grade PCa (grade group ≥2). We found that high LCω3-eicosapentaenoic acid (EPA) level in prostate tissue (odds ratio (OR) 0.25; 95% (confidence interval (CI) 0.08–0.79; p-trend = 0.03) was associated with lower odds of high-grade PCa. Similar results were observed for LCω3 dietary intake (OR 0.30; 95% CI 0.11-0.83; p-trend = 0.02) but no association for RBC. LCω3-EPA levels in the target prostate tissue are inversely associated with high-grade PCa in men with low-risk PCa, supporting that prostate tissue FA, but not RBC FA, is a reliable biomarker of PCa risk.

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Validation of the omega-3 fatty acid intake measured by a web-based food frequency questionnaire against omega-3 fatty acids in red blood cells in men with prostate cancer

Abstract: This study has shown that the web-FFQ is an accurate tool to assess total long-chain ω-3 FAs, EPA and DHA but not ALA intake in clinical trials and epidemiological studies carried out in men with PCa.

Cited by 12 publications

References 39 publications

Comparison of fatty acid intakes assessed by a cardiovascular-specific food frequency questionnaire with red blood cell membrane fatty acids in hyperlipidaemic Australian adults: a validation study

Comparison of fatty acid intakes assessed by a cardiovascular-specific food frequency questionnaire with red blood cell membrane fatty acids in hyperlipidaemic Australian adults: a validation study

Marine n-3 fatty acid consumption in a Norwegian renal transplant cohort: Comparison of a food frequency questionnaire with plasma phospholipid marine n-3 levels

Omega-3 Fatty Acids Survey in Men under Active Surveillance for Prostate Cancer: from Intake to Prostate Tissue Level

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