Validation of the RP?HPLC method for analysis of hydrochlorothiazide and captopril in tablets

An Overview of Analytical Determination of Captopril in Active Pharmaceutical Ingredients (API) Formulation and Biological Fluids

“…This method is [14] determined captopril in controlled release tablets and analyses was performed at room temperature on a reversedphase Phenomenex Luna C 18 column (250 mm × 4.6 mm), mobile phase water: methanol (45:55; v/v) and pH 2.5 at 1.0 mLmin −1 and the response was linear in the range of 0.3-1.5 mgmL −1 (r 2 = 0.9983). Validated RP-HPLC method for analysis of hydrochlorothiazide and captopril in tablets is reported by Ivanovic et al [15]. Jankowski et al, determined captopril in blood by HPLC [16].…”

Need for the Rational Use of Antibacterial in Paediatric Population

“…Improper use of antibiotics is a severe problem. The condition may become poorer as physicians performed less diagnostic tests and enhanced pressure exerted by the pharmaceutical industries to allow the easy availability of antibiotics without prescription in the developing world [15][16][17][18]. Table 1 presented that in (n=8, 9 %) cases culture sensitivity tests were performed while (n=82, 92 %) cases culture sensitivity tests were not performed.…”

Development and validation of reversed phase high performance liquid chromatography (RP-HPLC) for quantification of captopril in rabbit plasma

“…The hypotensive effect of CAP may results from the both inhibitory action on renin angiotensin system and simulating action on kallikrein kinin system [1]. It differs from different ACE inhibitors through the presence of a sulfhydryl group [2]. CAP is a white to offwhite powder which is soluble in water (4.60 mg/mL), methanol and ethanol.…”