Validation of the salivary urea test as a method to diagnose chronic kidney disease

Zúñiga, Marı́a Elvira; Estremadoyro, Luis; León, Cristian; Huapaya, Julio; Cieza, Javier

doi:10.5301/jn.5000022

Cited by 20 publications

(18 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Salivary urea[678917] and creatinine[1819] levels showed positive correlation with serum levels both in cases and controls. This finding is in accordance with the previous finding.…”

Section: Discussionmentioning

confidence: 99%

“…Similar findings were obtained by other authors. [1920] However, comparatively, lesser values of sensitivity of 80%, specificity of 71%, PPV of 80%, and NPV of 71% were demonstrated by Zuniga et al .,[8] whereas sensitivity of 80%, specificity of 90%, and area under the curve of 0.898 in ROC were demonstrated by Xai et al . [6]…”

Section: Discussionmentioning

confidence: 99%

“…[26789] Based on the availability of improved salivary diagnostic systems, this study was designed to test the diagnostic accuracy of salivary levels of creatinine, urea, sodium, potassium, and calcium using diagnostic validity test, receiver operator characteristic (ROC) curve, and we also aimed to determine cutoff values for salivary creatinine, urea, sodium, potassium, and calcium as indicators of dialysis need in patients with renal failure.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Diagnostic accuracy of salivary creatinine, urea, and potassium levels to assess dialysis need in renal failure patients

Bagalad

Madhushankari

et al. 2017

Dent Res J

View full text Add to dashboard Cite

Background:The prevalence of chronic renal failure is increasing because of increase in chronic debilitating diseases and progressing age of population. These patients experience accumulation of metabolic byproducts and electrolyte imbalance, which has harmful effects on their health. Timely hemodialysis at regular intervals is a life-saving procedure for these patients. Salivary diagnostics is increasingly used as an alternative to the traditional methods. Thus, the aim of the present study was to determine the diagnostic efficacy of saliva in chronic renal failure patients.Materials and Methods:This case–control study included 82 individuals, of which 41 were chronic renal failure patients and 41 were age- and sex-matched controls. Blood and saliva were collected and centrifuged. Serum and supernatant saliva were used for biochemical analysis. Serum and salivary urea, creatinine, sodium, potassium, calcium, and phosphorus were evaluated and correlated in chronic renal failure patients using unpaired t-test, Pearson's correlation coefficient, diagnostic validity tests, and receiver operative curve.Results:When compared to serum; salivary urea, creatinine, sodium, and potassium showed diagnostic accuracy of 93%, 91%, 73%, and 89%, respectively, based on the findings of study.Conclusion:It can be concluded that salivary investigation is a dependable, noninvasive, noninfectious, simple, and quick method for screening the mineral and metabolite values of high-risk patients and monitoring the renal failure patients.

show abstract

“…Salivary urea[678917] and creatinine[1819] levels showed positive correlation with serum levels both in cases and controls. This finding is in accordance with the previous finding.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Diagnostic accuracy of salivary creatinine, urea, and potassium levels to assess dialysis need in renal failure patients

Bagalad

Madhushankari

et al. 2017

Dent Res J

View full text Add to dashboard Cite

show abstract

“…Previous reports in humans have found that urea and creatinine can be measured in saliva and that salivary concentrations of both analytes are positively correlated to plasma levels [8][9][10]. In addition, it has been suggested that analysis of salivary urea and creatinine can be used in the diagnosis of chronic kidney disease (CKD) and also for monitoring progression and efficacy of haemodialysis [11].…”

Section: Introductionmentioning

confidence: 99%

Measurement of urea and creatinine in saliva of dogs: a pilot study

et al. 2018

View full text Add to dashboard Cite

BackgroundUrea and creatinine in saliva have been reported to be possible markers of chronic kidney disease (CKD) in humans. The aim of this study was to assess if urea and creatinine could be measured in canine saliva, and to evaluate their possible changes in situations of CKD.ResultsThe spectrophotometric assays for urea and creatinine measurements in saliva of dogs showed intra- and inter-assay imprecision lower than 12% and coefficients of correlation close to 1 in linearity under dilution tests. Healthy dogs showed median salivary concentrations of urea of 39.6 mg/dL and creatinine of 0.30 mg/dL, whereas dogs with CKD showed median salivary urea of 270.1 mg/dL and creatinine of 1.86 mg/dL. Positive high correlations were found between saliva and serum activities of the two analytes (urea, r = 0.909; P < 0.001; creatinine, r = 0.819; P < 0.001).ConclusionsUrea and creatinine concentrations can be measured in canine saliva with commercially available spectrophotometric assays. Both analytes showed higher values in saliva of dogs with CKD compared with healthy dogs and their values were highly correlated with those in serum in our study conditions.

show abstract

“…Advanced imaging techniques are just one of the several methods that can be used for early diagnosis of kidney involvement. It has been claimed that accurate analysis of salivary urea can be used as a proper tool in diagnosing of chronic kidney disease [149]. In addition, development of different imaging contrast agents improved the diagnosis accuracy of medical imaging techniques [15].…”

Section: Future Prospect: An Ideal Renal Imaging Modalitymentioning

confidence: 99%

Future of the Renal Biopsy: Time to Change the Conventional Modality Using Nanotechnology

Khosroshahi¹,

Abedi

Daneshvar

et al. 2017

International Journal of Biomedical Imaging

View full text Add to dashboard Cite

At the present time, imaging guided renal biopsy is used to provide diagnoses in most types of primary and secondary renal diseases. It has been claimed that renal biopsy can provide a link between diagnosis of renal disease and its pathological conditions. However, sometimes there is a considerable mismatch between patient renal outcome and pathological findings in renal biopsy. This is the time to address some new diagnostic methods to resolve the insufficiency of conventional percutaneous guided renal biopsy. Nanotechnology is still in its infancy in renal imaging; however, it seems that it is the next step in renal biopsy, providing solutions to the limitations of conventional modalities.

show abstract

Validation of the salivary urea test as a method to diagnose chronic kidney disease

Abstract: The salivary urea test has a great capacity to discriminate patients with chronic kidney disease from healthy people, and it was shown that the best cutoff point is 40 mg/dL.

Cited by 20 publications

References 22 publications

Diagnostic accuracy of salivary creatinine, urea, and potassium levels to assess dialysis need in renal failure patients

Diagnostic accuracy of salivary creatinine, urea, and potassium levels to assess dialysis need in renal failure patients

Measurement of urea and creatinine in saliva of dogs: a pilot study

Future of the Renal Biopsy: Time to Change the Conventional Modality Using Nanotechnology

Contact Info

Product

Resources

About